Pathology of the uterus





Objectives


On completion of this chapter, you should be able to:




  • Describe transabdominal, transvaginal, and translabial (transperineal) scanning and discuss the indications and advantages of each



  • Define the pathologies discussed in this chapter and describe their causes, clinical signs, and sonographic findings



  • Describe how to measure the endometrial thickness and the normal measurements for the various menstrual phases



  • Explain sonohysterography and the indications for performing this procedure



  • Identify the role of Doppler in evaluating pathology in the pelvis



  • Differentiate between the types of intrauterine contraceptive devices and describe the sonographic appearance of each





Sonography is traditionally applied in the female pelvis to delineate the size, texture, vascularity, and structure of pelvic anatomy. The examination may also supply information on the morphology of malfunctioning organs that seem normal on pelvic examination. Small, nonpalpable submucosal myomas or polyps may cause abnormal bleeding. The localization of intrauterine contraceptive devices (IUCDs) may be assessed by pelvic ultrasound examination. The homogeneity of the myometrium is assessed, and the thickness of the endometrial cavity is measured, in addition to the length and width of the uterus and cervix. Both transabdominal and transvaginal sonography are important in these evaluations. Transabdominal imaging furnishes a survey of anatomy, whereas transvaginal imaging provides better characterization of internal architecture of the vagina, cervix, and uterus. Color and spectral Doppler sonography can also play a role in assessing normal and pathologic blood flow, as well as identify vessels separate from fluid-filled structures. Newer techniques include sonohysterography, a process in which a small catheter, placed under ultrasound guidance, introduces sterile saline into the endometrial canal to provide a detailed evaluation of an intracavitary, endometrial, or submucosal lesion. Additionally, three-dimensional (3D) ultrasound now provides us with coronal representation of the uterus. Other imaging modalities used to evaluate pelvic anatomy and pathology include magnetic resonance imaging (MRI) and computed tomography (CT). These two modalities are particularly useful in the staging of malignant disease.




Pathology of the vagina and cervix


The vagina


The vagina runs anterior and caudal from the cervix, between the bladder and rectum ( Figure 43-1 ). Occasionally, sonography is used to characterize a vaginal mass, such as a Gartner’s duct cyst. These are the most common cystic lesions of the vagina and usually are found incidentally during sonographic examination. The most common congenital abnormality of the female genital tract is an imperforate hymen that results in obstruction. Obstruction of the uterus or the vagina may result in an accumulation of fluid (hydrometra), blood (hematometra), or pus (pyometra).




FIGURE 43-1


​Lateral view of the pelvis demonstrating the relationship of the pelvic organs to the bladder and pouch of Douglas.


Solid masses of the vagina are rare. As with carcinoma of the cervix, sonography is not used for diagnosis of carcinoma of the vagina, but it may play a role in staging. When found, the lesion is usually vaginal adenocarcinoma and rhabdomyosarcoma. The lesions appear as a solid mass, occasionally with areas of necrosis. Translabial scanning may be used to best evaluate the vaginal area.


The vaginal cuff


A vaginal cuff is seen in hysterectomy patients after surgery. The upper size limit of a normal vaginal cuff is 2.1 cm. If the cuff is larger than this or contains a well-defined mass or areas of high echogenicity, it should be regarded with suspicion for malignancy, especially in the patient who has a previous history of cancer. Nodular areas in the vaginal cuff may be due to postirradiation fibrosis.


Rectouterine recess


The rectouterine recess (posterior cul-de-sac) is the most posterior and inferior reflection of the peritoneal cavity (see Figure 43-1 ). It is located between the rectum and uterus and is also called the pouch of Douglas. Because of its location, it is frequently the site of intraperitoneal fluid collections. As little as 5 ml of fluid has been detected by transvaginal sonography. Fluid in the cul-de-sac is a normal finding in asymptomatic women and can be seen during all phases of the menstrual cycle. Pathologic fluid collections may be associated with ascites, blood resulting from a ruptured ectopic pregnancy, hemorrhagic cyst, or pus resulting from an infection. Pelvic abscesses and hematomas can also occur in the cul-de-sac. Sonographic characteristics help to differentiate these findings.


Cervix


Benign conditions.


Transvaginal sonography should be used to obtain high-quality images of the cervical area. The cervix lies posterior to the bladder between the lower uterine segment and the vaginal canal (see Figure 43-1 ). The cervical canal extends from the internal os, where it joins the uterine cavity, to the external os, which projects into the vaginal vault. It is a cylindrical portion of the uterus that enters the vagina and measures 2 to 4 cm in length. Transvaginal scanning of the cervix is performed after the patient empties her bladder. The transducer is inserted into the vagina with the patient supine, knees gently flexed, and hips elevated on a pillow. After the uterine cavity has been examined, the probe should be slowly pulled back slightly to image the internal and external cervical os. In the sagittal view, the handle of the transducer is slowly moved upward or back to better image the cervix (see Chapter 42 ). With gentle rotation and angulation of the transducer, coronal images are also obtained.


The most common finding is the presence of nabothian cysts ( Box 43-1 ), which result from chronic cervicitis and are seen frequently in middle-aged women. This cyst results from an obstructed dilated transcervical gland and is also called epithelial inclusion cyst.



BOX 43-1

Nabothian Cysts





  • Benign cysts in cervix



  • Chronic inflammatory retention cysts



  • Asymptomatic




On sonographic evaluation, these lesions appear along the cervical canal as discrete, round, fluid-filled anechoic structures, usually measuring less than 2 cm; they may be multiple ( Figure 43-2 ). Occasionally, nabothian cysts may have internal echoes that may be caused by hemorrhage or infection.




FIGURE 43-2


​Transvaginal sagittal image of the cervix shows multiple very small nabothian cysts just inferior to the endometrial cavity in the center of the cervix with increased through-transmission beyond. The areas of shadowing represent poor contact or air bubbles between the transducer and the vaginal wall.


Cervical polyps may present clinically with irregular bleeding. This benign condition arises from the hyperplastic protrusion of the epithelium of the endocervix or ectocervix. Chronic inflammation is the most likely factor. The polyps may be pedunculated, projecting out of the cervix, or broad-based, and ultrasound may or may not see cervical polyps, depending on their location. Women in their late middle age are more likely to develop polyps.


A small percentage of leiomyomas (myoma tumors) occur in the cervix ( Figure 43-3 ). When the myomas are small, the patient is asymptomatic, but as the mass enlarges, bladder or bowel obstruction may result. The myoma may be pedunculated ( Figure 43-4 ) and prolapse into the vaginal canal. Sonography may assist in determining the location of the stalk and the thickness of the stalk. Fluid infusion with sonohysterography enhances this visualization.






FIGURE 43-3


A, Endometrial adenocarcinoma presenting as a uterine mass. Without color Doppler the mass suggests a benign uterine myoma. B, Endometrial adenocarcinoma presenting as a uterine mass; without color Doppler, the mass is suggestive of a benign uterine myoma.



FIGURE 43-4


A, Transvaginal view of the uterus (UT) with a 5.5-cm hypoechoic myoma (mass outlined by calipers and arrows). B, Increased vascularity is noted in the cervical myoma. C, Large pedunculated fibroid is shown extending from the fundus of the uterus by a pedicle (arrows).


Cervical stenosis is an acquired condition with obstruction of the cervical canal at the internal or external os resulting from radiation therapy, previous cone biopsy, postmenopausal cervical atrophy, chronic infection, laser or cryosurgery, or cervical carcinoma. The menopausal patient may be asymptomatic even though the stenosis can produce a distended, fluid-filled uterus ( Figure 43-5 ), the result of an accumulation of uterine secretions, fluid (hydrometra), pus (pyometra), or blood (hematometra). Intracavitary fluid collections can be readily seen on ultrasound and may be an indirect indicator of cervical stenosis. Premenopausal patients may experience abnormal bleeding, oligomenorrhea or amenorrhea, cramping, dysmenorrhea, or infertility.




FIGURE 43-5


A–C, A 63-year-old asymptomatic woman on cyclic hormone replacement therapy demonstrates a large endometrial fluid collection. She underwent dilation for cervical stenosis, and bloody fluid was drained. D, Hematometrocolpos presents as a moderately echogenic collection in the cervical area.


Cervical carcinoma.


Squamous cell carcinoma is the most common type of cervical cancer. Precursors to this disease are the cervical dysplasias classified as mild, moderate, or severe. When the full thickness of the epithelium is composed of undifferentiated neoplastic cells, the lesion is referred to as carcinoma in situ. The detection of these abnormalities is attributed to screening with Papanicolaou (Pap) smears because most of the early lesions are asymptomatic. Advanced cervical cancer is usually evident clinically ( Box 43-2 and Figure 43-6 ). Sonography may demonstrate a solid retrovesical mass, which may be indistinguishable from a cervical myoma. Transvaginal and translabial ultrasound may demonstrate bladder, ureteral, vaginal, or rectal involvement and may be used in staging cervical cancer. CT and MRI are preferable, however, because they are superior methods for staging and evaluating lymphatic spread. Areas of increased echogenicity or hypoechoic areas with an irregular outline signify changes compatible with cervical carcinoma ( Figure 43-7 ). Multiple cystic areas within a solid cervical mass are a rare cervical neoplasm arising from the endocervical glands termed adenoma malignum or minimal deviation adenocarcinoma. Ultrasound is also helpful in guiding biopsies of the cervix and vagina.



BOX 43-2

Cervical Carcinoma





  • Affects women of menstrual age



  • Clinical findings: Vaginal discharge or bleeding



  • Sonographic findings: Retrovesical mass, obstruction of ureters, invasion of bladder





FIGURE 43-6


​Gross pathologic findings of cervical squamous cell carcinoma.



FIGURE 43-7


A, Transvaginal images of the lower uterine segment. The cervical area is enlarged and hypoechoic with decreased through-transmission. B, Color Doppler demonstrates increased vascularity in the mass. The patient was found to have cervical carcinoma at surgery.


Translabial or transperineal sonography may be used instead of or with the transvaginal approach to help define the cervical area. A 5.0- to 7.5-MHz sector or curvilinear transducer is covered with a sterile probe cover and applied to the vestibule of the vagina in the sagittal plane. Partial bladder filling may assist visualization of the cervical area. Rotation of the transducer obliquely in a counterclockwise direction shows the coronal images and defines the second plane for visualization. Positioning the patient with the hips elevated, as in the transvaginal approach, helps to displace pelvic gas and identify anatomy. Limitations can be overcome by elevation of the hips, better application of the transducer to the perineum, or changes in the orientation of the probe.




Pathology of the uterus


The uterus lies in the true pelvis between the urinary bladder anteriorly and the rectosigmoid colon posteriorly (see Figure 43-1 ). Uterine position is variable and changes with the degrees of bladder and rectal distention. The body of the uterus may lie obliquely on either side of the midline, which may mimic a mass on physical examination. Flexion refers to the axis of the uterine body relative to the cervix. Version refers to the axis of the cervix relative to the vagina. The uterus is usually anteverted and anteflexed. It may also be retroflexed (when the body tilts posteriorly) or retroverted (when the uterine fundus tilts backward) ( Figure 43-8 ). Transvaginal sonography has proven to be excellent for assessing the retroverted or retroflexed uterus because the transducer is close to the posteriorly located fundus. The size and shape of the normal uterus are related to age, hormonal status, and parity.




FIGURE 43-8


​Variations in uterine position.

A, Anteversion. B, Anteflexion. C, Retroflexion. D, Retroversion. E, Retroversion with retroflexion.


Common differential considerations for the uterus are seen in Box 43-3 .



BOX 43-3

Differential Considerations for the Uterus


Enlarged uterus





  • Pregnancy



  • Postpartum



  • Leiomyoma



  • Adenomyosis



  • Bicornuate or didelphic uterus



Uterine tumor





  • Leiomyoma



  • Carcinoma



Thickened endometrium





  • Early intrauterine pregnancy



  • Endometrial hyperplasia



  • Retained products of conception or incomplete abortion



  • Trophoblastic disease



  • Endometritis



  • Adhesions



  • Polyps



  • Inflammatory disease



  • Endometrial carcinoma



Endometrial fluid





  • Endometritis



  • Retained products of conception



  • Pelvic inflammatory disease



  • Cervical obstruction



Endometrial shadowing





  • Gas (abscess)



  • Intrauterine device



  • Calcified myomas or vessels



  • Retained products of conception




Normal variations of the uterus


Ultrasound is the first clinical examination ordered to evaluate the enlarged uterus. There are common variations of uterine morphology, the bicornuate or “two-horned uterus” and the didelphic uterus, that can be visualized with great specificity with sonography. These developmental variations are discussed in detail in the pediatric chapter. A detailed examination can reveal the endometrium in each horn, identify pathology, or document pregnancy ( Figure 43-9 ).




FIGURE 43-9


​Bicornuate uterus.

A, 3D reconstruction of a bicornuate uterus that clearly demonstrates the two uterine horns and echogenic endometrium. B, Transvaginal image of the bicornuate uterus. C, 3D rendering now gives us the opportunity to distinguish the bicornuate uterus from the septate uterus. Here the fundus is intact and there is a large wedge of myometrium between the 2 endometrial stripes. D, 3D rendering provides the opportunity to distinguish the bicornuate uterus from the septate uterus. In this image, the fundus is intact and there is a large wedge of myometrium between the two endometrial stripes.


Leiomyomas


Leiomyomas, commonly called myomas, are the most common gynecologic tumors, occurring in approximately 20% to 30% (or greater depending on the reference source) of women over 30 years old. They are more common in African American women.


Myoma tumors are composed of spindle-shaped, smooth muscle cells arranged in a whorl-like pattern with variable amounts of fibrous connective tissue, which can degenerate into a number of different histologic subtypes ( Figure 43-10 ). The tumors consist of nodules of myometrial tissue and are usually multiple. The myoma is encapsulated ( Figure 43-11 ) with a pseudocapsule and separates easily from the surrounding myometrium. With atrophy and vascular compromise as a result of outgrowing their blood supply, fibrotic changes and degeneration of the myomas can occur. Liquefaction, necrosis, hemorrhage, and ultimate calcification may take place. Hyalinization (development of an albuminoid mass in a cell or tissue) occurs most often, making the myomas appear more lucent or hypoechoic than the myometrium. Ten percent of myomas contain calcification, and a similar number have areas of hemorrhage. Other myomas contain tissue that has undergone necrosis and liquefaction and become myxoid in texture.




FIGURE 43-10


​Gross pathologic findings of the uterine cavity with multiple subserosal myoma tumors arising from its walls.



FIGURE 43-11


​Gross pathologic findings of the uterus with the encapsulated leiomyoma in the submucosal area.


Myomas are estrogen dependent and may increase in size during pregnancy, although about half of all myomas show little change during pregnancy. Myomas identified in the first trimester are associated with an elevated risk of pregnancy loss, and this risk is higher in patients with multiple myomas. They rarely develop in postmenopausal women, and most stabilize or decrease in size following menopause because of a lack of estrogen stimulation. They may increase in size in postmenopausal patients who are undergoing hormone replacement therapy. Tamoxifen has also been reported to cause growth in leiomyomas. A rapid increase in myoma size, especially in a postmenopausal patient, should raise the level of concern for a neoplasm.


Clinically, myomas cause uterine irregularity and enlargement with the sensation of pelvic pressure and sometimes pain. Patterns of irregular bleeding, menometrorrhagia, or heavy menstrual bleeding (menorrhagia) are the primary clinical problems. Myomas may contribute to infertility by distorting the fallopian tube or endometrial cavity; if located in the lower uterine segment or cervix, the tumor may interfere with normal vaginal delivery. Because of the increased estrogen during pregnancy, the tumor may grow and bleed within, causing pain. Box 43-4 summarizes the characteristics of leiomyomas.



BOX 43-4

Characteristics of Leiomyomas





  • Most common pelvic tumor



  • Smooth muscle cell composition



  • Fibrosis occurs after atrophic or degenerative changes



  • Degeneration occurs when myomas outgrow their blood supply; calcification



  • May be pedunculated



  • Clinical findings: Enlarged uterus, profuse and prolonged bleeding, pain




Leiomyomas can affect any portion of the uterine wall; however, the tumor may also be uncommonly found in the lower uterine segment, the cervix, and in the broad ligament. Leiomyomas are either submucosal leiomyomas (displacing or distorting the endometrial cavity with subsequent irregular or heavy menstrual bleeding), intramural leiomyomas (confined to the myometrium, the most common type), or subserosal leiomyomas (projecting from the peritoneal surface of the uterus). Sometimes subserosal leiomyomas become pedunculated and appear as extrauterine masses ( Box 43-5 and Figure 43-12 ).



BOX 43-5

Uterine Locations of Leiomyomas


Submucosal


Disruption into endometrial cavity—heavy bleeding; infertility


Intramural


Within myometrium—may enlarge to cause pressure on adjacent organs; infertility or recurrent pregnancy loss


Subserosal


Arise from myometrium, project exophytically—may enlarge to cause pressure on adjacent organs




FIGURE 43-12


​Gross pathologic findings of a pedunculated subserosal myoma of the uterus.


The signs and symptoms of leiomyomas depend on their size and location ( Figure 43-13 ). Submucosal myomas may erode into the endometrial cavity and cause irregular or heavy bleeding, which may lead to anemia. Fertility may be affected by submucosal or intramural myomas, which may impede sperm flow, prevent adequate implantation, or cause recurrent miscarriages. It is particularly important to diagnose submucosal leiomyomas because they are a well-established cause of dysfunctional uterine bleeding, infertility, and spontaneous abortion. Small submucosal leiomyomas may be removed hysteroscopically.




FIGURE 43-13


​Various locations of fibroid tumors found within the uterine cavity.


Uncommonly, a pedunculated subserosal lesion develops a long stalk and is migratory; it can implant into the blood supply of the broad ligament, omentum, or the bowel mesentery. Transvaginal sonography is often helpful in showing the uterine origin of the mass and identifying the stalk. Occasionally a pedunculated myoma becomes adherent to surrounding structures and develops an auxiliary blood supply.


Sonographic findings.


Leiomyomas have variable sonographic appearances. The earliest sonographic finding of myomas is the demonstration of uterine enlargement or irregular uterine wall contour with a heterogeneous myometrial texture pattern. The sonographer should also look for contour distortion along the interface between the uterus and the bladder ( Figure 43-14 ). The myoma alters the normal homogeneous myometrium. Discrete myomas usually are hypoechoic but can be hyperechoic if they contain dense fibrous tissue. Bright clusters of echoes occur with calcific deposits and produce typical distal acoustic shadowing ( Figure 43-15 ). Some myomas demonstrate an area of acoustic attenuation without a discrete mass, making it impossible to estimate size. The attenuation is thought to be caused by dense fibrosis within the substance of the tumor. The ultrasound technique and gain controls often must be manipulated to provide increased penetration, or a lower frequency may be necessary to fully evaluate the uterus. If extensive calcification is present, the uterus and adnexa may be difficult to image because of shadowing. In such cases, transvaginal imaging is helpful in visualizing the ovaries. Myomas as small as 0.5 cm can be detected by transvaginal sonography and their relationship to the endometrial cavity defined precisely. Larger myomas cause heterogeneous uterine enlargement and may be better outlined by transabdominal sonography.


May 29, 2019 | Posted by in ULTRASONOGRAPHY | Comments Off on Pathology of the uterus
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