Abnormal Placentation: Minimizing Surgical Blood Loss
Susan Kiernan O’Horo
Obstetrical hemorrhage remains a leading cause of maternal morbidity and mortality in the United States, affecting up to 18% of deliveries. It is commonly defined as blood loss exceeding 500 mL (1). The most common etiology of primary hemorrhage (defined as hemorrhage within 24 hours of delivery) is uterine atony, whereas secondary hemorrhage is usually attributable to retained products or, less commonly, arterial pseudoaneurysm. Interventional radiologists (IRs) developed uterine artery embolization (UAE) to control deep pelvic bleeding and have used embolization to effectively control postpartum hemorrhage (PPH) since it was first described in 1979(1).
Placental abnormalities may be increasing given the increase in advanced reproductive technologies, twin births, and cesarean sections (2). Placental abnormalities are divided by the depth of invasion into the uterine wall, with an accreta, the least invasive, and percreta, the most invasive. The prevalence of placental abnormalities is estimated at 1 per 500 pregnancies (2). The risks of abnormal placentation are life-threatening and include hemorrhage, infection, hysterectomy, and death. The IR is increasingly asked to help mitigate these risks with the placement of bilateral internal iliac artery (IIA) occlusion balloon catheters in an effort to reduce blood loss (3). Although the efficacy of this procedure is controversial, it may allow uterine conservation in women in whom the diagnosis of accreta is equivocal or to reduce intraoperative blood loss during cesarean hysterectomy. Cesarean hysterectomy is the traditional treatment for placental implantation anomalies.
Indications
1. Embolization for PPH unresponsive to conservative measures
2. Prophylactic IIA balloon occlusion
a. Control of hemorrhage during planned cesarean hysterectomy for known placental abnormality
b. Control of hemorrhage in women who have suspected placental abnormality prior to either cesarean hysterectomy or where possible uterine artery embolization
Contraindications
1. Contraindications include those of general angiography
a. Severe contrast allergy
b. Connective tissue disorder
c. Renal insufficiency
d. Uncontrolled coagulopathy
2. When the patient is already in an operative unit and too unstable to travel, hysterectomy may be more expeditious and save the patient’s life.
Preprocedure Preparation
1. PPH
a. Informed consent obtained from the patient and/or her health care proxy.
b. Foley catheter placement
c. Pedal pulses marked
d. Consideration for anesthesia assistance
2. Prophylactic IIA balloon occlusion
a. Clinic evaluation for a full explanation of the procedure, its risks, possible benefits, alternatives, and informed consent. Anesthesia consultation may also be appropriate.
b. Admission the morning of delivery
c. Baseline labs including a type and cross and complete blood count
d. Nil per os (NPO) after midnight the night before
e. Epidural anesthesia by anesthesiology
f. Foley catheter placement
g. Placement of pneumatic boots (sequential compression devices) for deep vein thrombosis (DVT) prevention
h. Pedal pulses marked
Procedure
1. PPH
a. The right common femoral artery (CFA) is accessed and a 5 Fr. sheath placed and connected to a heparin flush.
b. Using fluoroscopy, a flush catheter is advanced into the aorta, and a pelvic arteriogram is performed.
c. Typically, the contralateral (left) IIA is selected first with either a 4 Fr. or 5 Fr.
Cobra or Roberts uterine catheter (RUC). An arteriogram of the IIA is performed to define the uterine arterial anatomy and identify any and all bleeding sources whether from the uterine artery or other pelvic arterial vessels.
(1) With uterine atony, it is uncommon to see active extravasation. Embolization is performed in the absence of any angiography finding when there is a clinical indication of hemorrhage.
d. Typically, the left uterine artery is selected and arteriography performed.
The Roberts uterine catheter or Cobra 2 catheter can be used to engage the origin; however, care should be taken to avoid spasm because these patients often receive vasoconstrictors during resuscitation. A smaller catheter is preferable, and if not, a microcatheter may be used if superselective catheterization is required.
e. Embolization is performed on the left uterine artery.
(1) Embolization is typically performed with absorbable gelatin sponge (Gelfoam) either as slurry (macerated with dilute contrast) or as a pledget because the goal is to induce a temporary, reversible ischemia.
Embolization is performed to stasis.
(2) If a pseudoaneurysm is seen, consideration should be given to superselective coil embolization.