Magnetic Resonance Angiography
Nanda Deepa Thimmappa
Martin R. Prince
Just as with conventional angiography, it is essential to learn all aspects of the operation of magnetic resonance imaging (MRI) equipment to select the appropriate imaging coil and sequences (see LearnMRI.org). It is important to evaluate patients prior to imaging in order to determine the specific clinical issues that need to be addressed, and to assess how cooperative the patient is likely to be with suspending respiration and remaining still for the scans. It is especially critical to determine the extent of vascular anatomy to be examined because it does not necessarily correspond to the traditional organ-based magnetic resonance (MR) anatomical regions. Technologists are often not familiar with the regions of coverage required for vascular studies and need guidance from the radiologist.
Preprocedure Preparation
1. Safety screening: Before accepting a patient for MRI, do a quick check for the major contraindications (e.g., pacemakers, cochlear implants, and brain aneurysm clips). The technologist must screen for other less frequent contraindications, including metallic foreign bodies in the orbits and certain medical implants. Vena cava filters, especially if nonferromagnetic and remote from the
imaging site, do not generally pose a safety hazard, but they may create artifacts if included in the imaging field.
imaging site, do not generally pose a safety hazard, but they may create artifacts if included in the imaging field.
2. Nephrogenic systemic fibrosis (NSF): If the patient is an inpatient, check the serum creatinine and calculate the glomerular filtration rate (GFR) (visit www. MDRD.com for GFR calculator). If GFR <30 mL per minute, avoid high doses of gadolinium (Gd) and consider noncontrast magnetic resonance angiography (MRA) techniques. Patients in acute renal failure should not receive Gd until the serum creatinine recovers toward normalcy or hemodialysis is instituted. Outpatients should be asked if they are on dialysis or about to begin dialysis. All dialysis patients should have the MR scheduled for just prior (within 24 hours) to the next dialysis treatment session. For patients at risk for NSF, the macrocyclic agents such as Gadobutrol (Gadavist, Bayer, Berlin, Germany), Gadoteridol (ProHance, Bracco, Princeton, NJ) or Gadoterate Meglumine (Dotarem, Guerbet, Bloomington, IN) are safer than the linear agents. Agents with biliary excretion in addition to renal excretion including Gadobenate Dimeglumine (MultiHance, Bracco, Princeton, NJ), Gadexetate Disodium (Eovist, Bayer, Berlin, Germany), and Gadofosveset Trisodium (Ablavar, Lantheus Medical Imaging) also have fewer or no reported cases complicated by NSF. Gadobenate Dimeglumine and Gadofosveset Trisodium are U.S. Food and Drug Administration (FDA)-approved for aorto-iliac MRA. Keep in mind, however, that Gadodiamide (Omniscan, GE Healthcare, Princeton, NJ) has the lowest rate of allergic reactions and may be well suited for patients at risk of allergic reactions and outpatient imaging centers with limited ability to handle a code situation.
3. Clothing: Remove all clothing (including bras) with metallic components such as zippers, snaps, etc. Have the patient wear a hospital gown. Remove hairpins and metallic jewelry. Nonmagnetic gold and silver rings may be worn so they do not get lost, but they should not be near or within the field of interest. If there is a question about safety, metallic paraphernalia should be tested with a small hand magnet.
4. Sedation: Patients with claustrophobia will benefit from diazepam (Valium) 5 to 10 mg by mouth (PO) or lorazepam (Xanax) 1 to 2 mg PO taken 20 to 30 minutes prior to MR scanning. The patient should not be given the sedative until arriving at the scanner in case the facility is behind schedule. Sedated patients need a responsible adult escort to go home.
5. Intravenous (IV) lines
a. For gadolinium-enhanced MRA (Gd-MRA), a right arm IV access is preferred because this provides the most direct route to the central circulation. It is acceptable to use a small-gauge IV access (minimum 22 gauge or high flow 24 gauge) in the antecubital fossa, hand, or wrist. However, if the IV access is tenuous, consider using a nonionic, low-osmolar Gd contrast preparation to avoid potential pain caused by extravasation of high-osmolar ionic Gd preparations.
b. For hand injection of Gd, use the Smart Set (Topspins, Ann Arbor, MI). This device has a valve mechanism to allow automatic switching from contrast infusion to saline flush without excessive force or risk of breaking connections. It also has the optimum length, caliber, and fittings to allow easy IV injection of contrast by an operator outside the magnet. Caution is urged with power injectors because they are prone to misadministration, extravasation, and a greater risk to the patient in the event of a contrast reaction compared to hand injection because the pump is activated remotely from the control room.
6. Coil selection: Coil selection has to be optimized because the choice determines the available field-of-view (FOV) and the signal-to-noise ratio (SNR)—both of which significantly affect image quality. Because of the complexity of coil selection, many radiologists leave this up to the discretion of the technologist. However, it is important to be aware of the basic coil selection principles because
technologists will generally pick the coil that makes the exam easiest to perform instead of one that produces the highest image quality.
technologists will generally pick the coil that makes the exam easiest to perform instead of one that produces the highest image quality.
a. Use the smallest possible coil that still covers the anatomy of interest.
b. Choose coils that are used routinely and reliable such as the head, knee, torso, and body coils. Keep in mind that circumferential coils with birdcage construction (head, body, and knee coils) tend to have the most homogeneous sensitivity to MR signal and are unlikely to produce confusing bright or dark spots on the images.
c. When using coil arrays, make sure all elements are working properly. One bad element can reduce vascular signal locally giving the false impression of disease.
Procedure
It is essential to keep the examination time as short as possible so that the patient is able to tolerate holding still for the entire exam. Try to keep the total imaging time below 25 minutes so that the examination can be completed within 45 minutes.
1. Protocols
a. Scout sequences: When selecting protocols for MRA examinations, it is useful to start with a large-FOV, low-resolution scout sequence to guide the prescription of subsequent smaller FOV sequences confined to the vascular anatomy of interest (1,2,3,4).
(1) Single-shot fast spin echo (SSFSE) (General Electric, Milwaukee, WI) or half-Fourier acquisitions with single-shot turbo-spin echo (HASTE) (Siemens, Erlangen, Germany) are also useful as “black blood” scout sequences.
(2) Three-plane ungated steady state free precession (SSFP) is a very useful “bright-blood” localizer because it has high SNR and yet is fast enough to minimize motion artifact and cover a large FOV with multiple slices in a short time.
b. Multiplanar images: Take advantage of the multiplanar imaging capability of MRI to optimize visualization of anatomy in as many different orientations as possible. For this reason, try to have at least one sequence in each cardinal plane: axial, coronal, and sagittal.
c. Contrast mechanisms: MRI has numerous contrast mechanisms that can be optimized to see anatomy and pathology in various ways. Some of the most popular contrast mechanisms for MRA studies include:
(1) T1-weighted (T1-W): high SNR with black blood
(2) Proton density: higher SNR than T1-W and black blood
(3) T2-weighted (T2-W): tumors, inflammation, and other lesions are bright, whereas fast flowing blood is black. Slow flowing blood in hemangiomas or slow flow vascular malformations may be bright. This sequence is usually performed with fat saturation.
(4) Short T1 inversion recovery (STIR): like T2-W with fat saturation but without the degradation due to field inhomogeneity. Veins and especially vascular malformations are typically very bright due to slow flow.
(6) SSFP: High SNR, bright-blood MRA—prone to artifacts especially at larger FOV but the small FOV renal MRA implementations (InHance, timeslip, Native TrueFISP, B-Trance) are often excellent
(7) Three-dimensional (3D) Gd-MRA: provides a robust bright-blood MRA sequence similar to conventional angiography—least prone to artifacts.
(8) Time-of-flight (TOF): bright-blood MRA sequence—subject to flow and motion artifacts. ECG gating reduces artifacts due to arterial pulsation.
(9) Cine-SSFP: SSFP images acquired multiple times during the cardiac cycle and displayed as a movie to show variations between systole and diastole
(10) Phase contrast-MRA (PC-MRA): allows quantification of intraluminal blood flow and demonstrates flow disturbances
(11) Arterial spin labeling: Blood is excited proximal to the region of interest (ROI) and imaged after flowing into the ROI.
(12) Fresh blood imaging (Delta flow, native Space, Trance): Images gated to systole are subtracted from images gated to diastole to show arteries without Gd.
(13) “TimeSlip” (Inhance, B-Trance, native trueFISP): good for renal arteries in patients with fast blood flow. Gd injection is not necessary.
2. MRA pulse sequences
a. 3D Gd-MRA: This is the most robust sequence for evaluating vascular anatomy and pathology. Figure e-70.1 is a 3D Gd-MRA study from the abdominal aorta to the proximal calf region. The image illustrates the ability of the technique to demonstrate bilateral common iliac and popliteal artery aneurysms. 3D Gd-MRA is performed similarly to CT angiography by acquiring a 3D spoiled gradient echo (SPGR) pulse sequence during the arterial phase of a contrast bolus (5) or Time Resolved Imaging of Contrast KineticS (TRICKS) during arterial and venous phases. Use the shortest possible repetition time (TR) and echo time (TE), while being careful not to make the bandwidth (BW) too high. A flip-angle of about 30 degrees is good for the arterial phase but should be lower for venous and equilibrium phases when Gd concentration has diminished. The bolus duration should equal half the scan duration—timed for maximum arterial Gd concentration “opacification” to coincide with acquisition of center of k-space. The contrast dose should not exceed 0.1 mL per kg in any patient at risk of NSF (GFR <30). More advanced, state of the art MR scanners generally can produce high quality MRA with lower Gd doses. Alternatively, higher quality MRA can be achieved using a blood pool contrast agent such as Gadofosveset Trisodium (Ablavar, Lantheus, Billerica, MA). This contrast lingers in the blood for hours so it is excellent for venous imaging. Diagnostic MRA can be obtained up to 8 hours after the injection, for example, in patients who leave before the exam is completed.
(1) Bolus timing for long acquisitions: For long acquisitions, lasting more than 100 seconds, timing is easy because errors of 10 to 15 seconds are small relative to the total scan duration.
(a) Use sequential ordering of k-space, so that the center of the k-space is collected during the middle of the acquisition.