104

FIGURE 104-1

FIGURE 104-2

FIGURE 104-3

FINDINGS Figure 104-1. Axial T2WI through the basal ganglia. There is diffuse white matter (WM) hyperintensity with involvement of the globus pallidus and anterior aspect of the cerebral peduncles (arrows). Figure 104-2. Coronal T2WI through the basal ganglia. There is hyperintensity in the WM and bilateral globus pallidus (arrows). Figure 104-3. Axial T1 inversion recovery image through the basal ganglia. There is marked hypointensity throughout the WM.

DIFFERENTIAL DIAGNOSIS Pelizaeus-Merzbacher disease, Alexander disease, Canavan disease mucopolysaccharidoses, megalencephalic leukodystrophy with cysts.

DIAGNOSIS Canavan disease.

DISCUSSION

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