Coronal, sagittal, axial, and MIP images from FDG-PET demonstrate diffusely increased uptake in the entire visualized marrow distribution.

Differential Diagnosis

•  Benign marrow stimulation: Homogeneous, intensely increased uptake in the axial and proximal appendicular skeleton (red marrow) diffusely makes this the most likely diagnosis.

•  Widespread osseous tumor: This can look similar if severe, but uptake will usually be more heterogeneous.

•  Altered biodistribution: