Introduction

Diffuse parenchymal hepatic diseases usually represent a failure in a hepatic metabolic pathway and usually are a result of storage, vascular or inflammatory disorders. The liver plays a vital role in the metabolism of amino acids, carbohydrates and lipids, as well as proteins synthesis. The basic pathophysiology of most diffuse parenchymal hepatic diseases is usually a failure in one of these metabolic pathways. MRI with recent advances like chemical shift imaging, fat, iron quantification sequences and elastography are the mainstay for noninvasive diagnosis of diffuse liver diseases and may obviate the need for biopsy. This chapter focuses on imaging-based classification of diffuse liver diseases and describes techniques for diagnosis and quantification of commonly encountered pathologies.

Diffuse liver disease can be classified into 3 categories (Table 9.10.1)

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