Mastocytosis



Mastocytosis


Michael P. Federle, MD, FACR





Key Facts


Imaging



  • Systemic disease with mast cell proliferation



    • Urticaria pigmentosa is most common form


  • Gastrointestinal tract involved in 16% of cases



    • Peptic ulcer disease and malabsorption


    • Duodenum and SB: Thick folds, fast transit


    • Mucosal nodularity (2-3 mm sand-like nodules)


  • CT: Lymphadenopathy; thickened omentum and mesentery



    • Hepatomegaly (40% of adult cases)


    • Biliary tree: Infiltration of walls; irregular strictures


    • Splenomegaly with nodular deposits (50% of cases)


    • Sclerotic &/or lytic lesions in axial skeleton


  • Bone scan: Lytic lesions, osteoporosis or osteosclerosis


Top Differential Diagnoses



  • Carcinoid tumor


  • Zollinger-Ellison syndrome


  • Sprue-celiac disease


  • Malabsorption conditions


  • Primary sclerosing cholangitis (for biliary involvement)

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Jun 13, 2016 | Posted by in GASTROINTESTINAL IMAGING | Comments Off on Mastocytosis

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