MR Imaging of Diffuse Peripheral Neuropathy





MR neurography can aid diagnosis and management of diffuse peripheral neuropathies. Diffuse peripheral neuropathies can be due to a variety of causes, including hereditary, inflammatory/autoimmune, infectious, and secondary to systemic conditions, such as diabetes mellitus. MR findings include long-segment (typically more than 6 cm) nerve enlargement and signal hyperintensity and may involve a solitary nerve or multiple nerves, depending on the underlying condition. Importantly, in the interpretation of diffusely abnormal nerves by imaging, neoplastic cause should be ruled out.


Key points








  • Diffuse peripheral neuropathy can be diagnostically challenging owing to the involvement of multiple nerves and the wide range of pathologic conditions that can lead to diffuse peripheral nerve abnormalities on imaging.



  • Diffuse peripheral nerve lesions are categorized as either solitary neuropathy or polyneuropathy and entail long-segment involvement, which is defined as greater than 6 to 12 cm.



  • MR neurography can localize and characterize nerve pathologic condition and help differentiate between different causes of peripheral neuropathy.




Abbreviations



















































ADC apparent diffusion coefficient
AIDP acute inflammatory idiopathic polyneuropathy
CIP critical illness neuropathy
CIPD chronic inflammatory idiopathic polyneuropathy
CMT Charcot-Marie-Tooth syndrome
DA diabetic amyotrophy
FS fat-suppressed
MIP maximum intensity projection
MMN multifocal motor neuropathy
MPR multiplanar reformation
MRN magnetic resonance neurography
POEMS polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder, skin changes
STIR short tau inversion recovery
VEGF vascular endothelial growth factor
WB whole body



Introduction


Peripheral neuropathy can be a debilitating condition, with overall prevalence of 1% in the general population and 7% in the elderly. Symptoms include pain, weakness, loss of function, and in some cases, end-organ damage with muscle atrophy. Although the clinical examination and electrodiagnostic studies are traditional methods of assessing peripheral neuropathy, imaging is playing an increasingly important role in the diagnosis of peripheral nerve disorders. The distribution of peripheral neuropathy as focal or multifocal, symmetric or asymmetric, and proximal or distal is a helpful feature in determining the underlying cause. MR imaging of peripheral nerves, also known as magnetic resonance neurography (MRN), allows for visualization of nerve architecture, course, and signal. MRN can localize and characterize nerve pathologic condition and help differentiate between different causes of peripheral neuropathy with high diagnostic accuracy. ,


In the recently described Neuropathy Score Reporting and Data System, diffuse peripheral nerve lesions were defined as diffuse long-segment nerve hyperintensity on T2-weighted imaging or enlargement ( Fig. 1 ), with “long-segment” involvement being defined as greater than 6 to 12 cm. Diffuse peripheral nerve lesions were categorized as either diffuse solitary/mononeuropathy (D1, affecting a single nerve) or diffuse polyneuropathy (D2, affecting multiple nerves, either unilateral or bilateral). , There is otherwise limited prior literature on the utility of MRN in diffuse peripheral nerve lesions. Long-segmental involvement of single or multiple nerves on MR imaging can be diagnostically challenging owing to the nonspecific appearance and the wide range of pathologic conditions that can lead to diffuse peripheral nerve lesions ( Table 1 ).




Fig. 1


Diffuse polyneuropathy. A 10-year-old boy presented to the neurology clinic for a gait abnormality (walking on the lateral aspect of his right foot with callus formation) and a painless closed pressure ulcer developing at the lateral aspect of the midfoot. Physical examination revealed a high arch of the right foot and a 3-cm leg length discrepancy. Whole-body (WB) MR imaging was performed for clinical suspected peripheral nerve tumor syndrome. Coronal Short Tau Inversion Recovery (STIR) WB-MR imaging maximum intensity projection (MIP) ( A ) shows bilateral lumbosacral plexus enlargement ( short arrow on A ) and asymmetric long-segmental (>6 cm) enlargement of the right sciatic nerve ( long arrows on A and B ) with extension into the right posterior femoral cutaneous nerve ( dotted arrows on B ), tibial nerve ( dashed arrow on C ), and common peroneal nerve ( solid arrow on C ) best seen on axial images through the right proximal thigh ( B ) and calf ( C ). MR imaging was useful in visualizing the distribution and extent peripheral nerve abnormality and selection of biopsy site and ultimate diagnosis of KRAS-mediated rasopathy and localized neuropathy.


Table 1

Cause and common causes of diffuse peripheral mono- or polyneuropathy































Cause Most Common Cause
Immune-mediated Acute inflammatory idiopathic polyneuropathy (AIDP), chronic inflammatory idiopathic polyneuropathy (CIDP), multifocal motor neuropathy (MMN), neuralgic amyotrophy/brachial plexitis
Infectious Leprosy, Epstein-Barr virus, Herpes Zoster virus, long-standing HIV, and B burgdorferi (Lyme disease)
Hereditary Charcot-Marie-Tooth types 1A, 1B, and X-linked
Systemic disease–related Diabetes mellitus, long-standing HIV infection, critical illness, end-stage kidney disease/uremic, amyloidosis, hypothyroidism, vitamin deficiency
Toxic Alcohol, chemotherapeutic agents, most heavy metals, many commonly used medications
Environmental Vibration-induced, prolonged cold exposure, hypoxemia
Neoplastic/paraneoplastic Secondary nonneurogenic tumors due to contiguous spread, hematologic malignancy, POEMS syndrome
Idiopathic No specific cause


Diffuse peripheral mononeuropathies can be caused by neoplasms or a wide variety of entities, such as infection, ischemia, trauma including traction nerve injury, idiopathic entities, such as hypertrophic mononeuropathy, and systemic disorders. Diffuse peripheral polyneuropathies can also be neoplastic in cause and otherwise be autoimmune, hereditary, toxin-related, systemic disease-related, or idiopathic. The purpose of this review article is to describe the key clinical and imaging features of diffuse peripheral mononeuropathy or polyneuropathy that can aid the radiologist in arriving at an accurate diagnosis or generate a succinct and relevant differential diagnosis.


MR imaging features of diffuse peripheral neuropathy


MR imaging findings of diffuse peripheral neuropathy include long-segment T2 signal hyperintensity and/or enlargement of a single nerve or multiple nerves. , The degree of signal hyperintensity and enlargement, the number of nerves affected, the distribution, and the pattern of abnormal findings vary based on the cause of diffuse peripheral neuropathy. Intravenous contrast administration is not typically necessary for the assessment of diffuse peripheral neuropathy, although contrast enhancement can be a supportive feature for the diagnosis of neoplastic cause, noting that contrast enhancement can also be a feature of nonneoplastic pathologic condition. MR imaging findings can complement clinical history, physical examination, and laboratory analysis to aid in diagnosis of diffuse peripheral neuropathy, assess for treatment response, and guide management decisions. A discussion of imaging features found with different causes is discussed in further detail in later discussion and is summarized in Table 2 .



Table 2

Clinical characteristics, distribution, and key MR imaging features associated with common causes of diffuse peripheral mononeuropathy or polyneuropathy




















































Cause Clinical Characteristics MR Imaging Features
Acute inflammatory idiopathic polyneuropathy Symmetric polyneuropathy with lower-extremity weakness or flaccid paralysis that progresses to upper extremities
Antecedent event, such as infection
Peak symptoms within 3–4 wk
Albuminocytologic disassociation on LP
Decreased or absent DTRs
Thickening and enhancement of intraspinal nerve roots; cauda equina and conus medullaris
Chronic inflammatory idiopathic polyneuropathy Symmetric polyneuropathy characterized by proximal and distal sensorimotor involvement
Gradually progressive over several months
Albuminocytologic disassociation on LP
Decreased or absent DTRs
Symmetric (> asymmetric) thickening and enhancement of peripheral nerves, brachial and lumbosacral plexus and nerve roots
Facilitated diffusion on DWI
Multifocal motor neuropathy No objective sensory abnormalities
Upper-limb motor deficit Decreased/absent DTRs in affected limb
Asymmetric thickening of the affected upper-extremity motor peripheral nerve
Neuralgic amyotrophy Abrupt onset of severe pain followed by patchy weakness in the distribution of the upper and/or middle brachial plexus
± Winged scapula
Asymmetric focal or multifocal thickening of the brachial plexus or upper extremity/chest wall peripheral nerve or nerves ± hourglass constrictions
Charcot-Marie-Tooth Symmetric polyneuropathy
Distal weakness and atrophy
Foot drop
Pes cavus
Family history
Symmetric masslike thickening of the peripheral nerves, brachial and lumbosacral plexus, and nerve roots with variable to no enhancement
Facilitated diffusion on DWI
Diabetic amyotrophy Asymmetric polyneuropathy
Acute onset of unilateral leg pain followed by progressive weakness that involves the contralateral leg
Asymmetric thickening of lumbar plexus or lower-extremity peripheral nerve
Amyloidosis Mixed sensory and motor peripheral neuropathy ± autonomic dysfunction Maybe asymmetric or symmetric multifocal peripheral nerve/plexus enlargement, propensity for carpal tunnel syndrome
Critical illness polyneuropathy Severe sepsis and multiorgan failure
Failure to wean from the ventilator
COVID-19 infection
Decreased or absent DTRs
Asymmetric thickening of upper- and/or lower-extremity peripheral nerves/plexi
Radiation-induced neuropathy/plexopathy Antecedent history of malignancy treated with radiation Asymmetric thickening with variable “tram-track” enhancement concordant with the radiation field
Facilitated diffusion on DWI
POEMS syndrome Organomegaly, endocrinopathy, monoclonal plasma cell disorder, skin changes
Symmetric distal painful (sensory before motor) and progressive, proximal spread
Symmetric thickening and enhancement of peripheral nerves, brachial and lumbosacral plexus, and nerve roots
Malignant peripheral neuropathy/plexopathy History of metastatic disease/hematologic malignancy
Painful neuropathy
Hypermetabolic activity corresponding to the plexus or peripheral nerve on PET imaging
Asymmetric masslike thickening and enhancement of plexus or peripheral nerve
Adjacent or contiguous neoplasm
Restricted diffusion on DWI

Abbreviations: DTR, deep tendon reflexes; DWI, diffusion-weighted imaging; LP, lumbar puncture.


Immune-mediated neuropathies


Autoimmune processes can affect peripheral nerves and result in both acute and chronic peripheral neuropathy. Acute autoimmune neuropathy typically presents with sudden-onset pain, weakness, and paresthesia and has been associated with infection, trauma, and surgery.


Acute Inflammatory Idiopathic Polyneuropathy


Acute inflammatory idiopathic polyneuropathy (AIDP), or Guillain-Barre syndrome, results in acute progressive relatively symmetric motor and sensory symptoms with associated diminished or absent deep tendon reflexes. Lumbar puncture often shows albuminocytologic dissociation (elevated protein and normal to mildly elevated leukocyte count [usually <5 cells/mm 3 ]). Typically, the diagnosis of AIDP is made on a combination of clinical features and cerebrospinal fluid analysis. In atypical clinical presentations or equivocal lumbar puncture, imaging can be performed to support the diagnosis and exclude other causes of polyneuropathy. MR findings of AIDP ( Fig. 2 ) include thickening and enhancement of the anterior more than posterior spinal nerve roots, particularly the cauda equina and conus medullaris. In subtle cases, thickening of the intraspinal nerve roots may be challenging to detect, and the administration of intravenous contrast material may be useful. Treatment is conservative, and recovery is expected over time, generally 4 to 6 weeks. MRN is helpful for diagnosis and to exclude other potential causes of the patient’s symptoms.


Jul 6, 2025 | Posted by in MAGNETIC RESONANCE IMAGING | Comments Off on MR Imaging of Diffuse Peripheral Neuropathy

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