Technical points are as follows: (1) Theoretical merits of MWA make it produce higher intratumoral temperatures, larger ablation zones, less ablation time, and less dependence on the electrical conductivities of tissue consistently. Also, the energy delivery is less controlled by the exponentially rising electrical impedance of tumor tissue. (2) According to our experience, long-duration ablation (about 1 min more than the ablation time of tumors in safe sites) may cause gradual ablation of the tumors adjacent to large vessels and compensate the defect from heat-sink effect in the large vessels. (3) After the first procedure, contrast-enhanced imaging (CEUS, computed tomography, or magnetic resonance imaging) should be performed in time in the following 3 days to examine whether any residual cancer still have not been eliminated. Consequently, a second session will be determined to achieve complete ablation. (4) With MWA emission, ethanol ablation should be performed at the same time for tumors adjacent to both large vessels and bile ducts. The purpose of the procedures is to wipe out the tumor tissue adjacent to the biliary duct and blood vessel and to avoid the overheating injury to those vital tissues by means of increasing thermal conduction and diffusivity [27]. (5) Real-time peritumoral temperature monitoring should be used as an indicator for complete MWA. (6) Rich experience in detailed treatment protocol, accurate image guiding, and proper placement of antennas contribute a lot for the success of the treatment (Figs. 7.1 and 7.2) [33].