Second and Third Trimester Fetus

Chapter 14. Second and Third Trimester Fetus



Patient Preparation






• No voiding immediately before the examination; some fluid in the bladder is needed to visualize the urinary bladder and may aid in visualization of the cervix and LUS.


Equipment and Technical Factors






• A curved linear transducer is commonly used. An EV transducer may be used to visualize the cervix and LUS, or the presence of a pathologic condition must be more clearly documented; ensure that the department protocols are followed. EV imaging may be contraindicated in the presence of vaginal bleeding, leakage of fluid, or cervical dilation.


• Fetal, uterine, or ovarian Doppler imaging may be performed as requested; Doppler imaging may be used in the evaluation of pathologic conditions found during the study.


• MI and TI settings must comply with the ALARA principle.


Imaging Protocol






• Determine the location of the placenta and the fetal lie; assess the presence of pathologic conditions or anatomical variants. The presence and location of fibroid(s) should be documented. The ovaries and adnexal areas should be evaluated.


• Braxton-Hicks contractions may occur throughout pregnancy. This type of contraction usually lasts 20 to 30 minutes and can occur in any area of the uterus (may mimic fibroid, placenta previa, or mass).



Measurements






• The uterus is generally not measured during pregnancy; however, fibroid size should be documented.


Fetal biometry (BPD, HC, AC, FL)






• Compare measurements obtained (recommend average of three of each required measurement) with patient’s estimated due date and standardized charts or use the equipment software.


Other






• Thorax/abdomen: 1:1 ratio


• Occipital-frontal diameter/BPD × 100: CI to correlate with BPD


• Ventricular atrium: <1 cm


• Cisterna magna: 5.0–10.0 mm


• Nuchal translucency at 9–13 weeks: <3.0 mm


• Nuchal thickness at 16–22 weeks: <6.0 mm


• Amniotic fluid: Amniotic fluid index (AP dimension of four quadrants = 5.0–24.0 cm)


• Single pocket (AP dimension = 2.0–8.0 cm)


• Ocular diameter


• All long bones






































Second and Third Trimester Fetus
Sonographic Finding(s) Clinical Presentation Differential Diagnosis Next Step



Two or more of the following are noted:




Ascites


Pleural effusion


Pericardial effusion


Edema


Placentomegaly


Polyhydramnios



Uterus is large for dates


Rh sensitized (immune hydrops/fetal anemia)



Hydrops fetalis


Isolated ascites, pleural effusion, pericardial effusion



Nonimmune causes include maternal infection, chromosomal abnormalities (especially Turner’s syndrome, trisomies 13, 18, and 21), and heart failure


Associated with fetal tachycardia


Elevated PSV from the MCA associated with immune hydrops



Fetal biometry: all measurements (including weight) are below 10th percentile for gestational age


Fetal soft tissues may appear thin


Placenta may appear thin and small


Oligohydramnios (especially in late pregnancy) may be present



Uterus measures small for dates


Previous sonogram demonstrated below normal or normal fetal gestational age



Symmetric IUGR


Wrong dates


SGA fetus



Associated with both chromosomal and nonchromosomal abnormalities


BPP score, umbilical artery Doppler, or S/D ratio may be abnormal if this is true symmetric IUGR


Symmetric IUGR requires at least two sets of biometry to confirm finding
Fetal abdomen measures below 10th percentile for gestational age but head and femur measurements are within normal limits for gestational age


Uterus measures appropriately or small for dates


Previous sonogram demonstrated normal fetal measurements for gestational age
Asymmetric IUGR


Placental insufficiency may be documented by Doppler interrogation of umbilical artery MCA S/D ratio < umbilical artery S/D ratio


Pulsatile flow in umbilical vein



Placenta may demonstrate aging (grade 3 or 4) early in pregnancy


Oligohydramnios


Echogenic bowel may be noted
Maternal diabetes or hypertension before pregnancy



Fetal biometry reveals fetal abdominal measurement above 90th percentile for gestational age


Evidence of skin thickening around fetal head and trunk; prominent fetal cheeks



Uterus measures large for dates


Commonly seen in cases of maternal diabetes, obesity, advanced maternal age, and multiparity
Macrosomia In suspected macrosomia, carefully scan the anatomy to document size of fetal liver and to search for anomalies such as GI tract, cardiovascular system (thickening of the cardiac IVS), CNS, and VACTERL
Possible mild polyhydramnios may be present




Increased size of facial cheeks is due to fat deposits


Placenta usually demonstrates increased thickness


















































































































Second and Third Trimester Fetal Head and Neck
Sonographic Finding(s) Clinical Presentation Differential Diagnosis Next Step



Unable to obtain BPD/no skull is visible


Fetal face has “mask” or “frog-face” appearance


Polyhydramnios
Uterus may measure large for dates Anencephaly Associated with CNS and other anomalies, hydronephrosis, diaphragmatic hernia, cleft lip, and cardiac anomalies; may also be caused by amniotic band



Cerebellar hemispheres lack rounded appearance; unable to visualize cerebellum


Asymmetrical ventriculomegaly (third and lateral ventricles) with splaying of lateral ventricles; small cranial size


Skull demonstrates depression of frontal bones
Asymptomatic Chiari type II


Associated with spina bifida and agenesis of the corpus callosum


Normal frontal bones may demonstrate slight depression



Third ventricle is seen more superior in midline of brain


Lateral ventricles are seen more lateral and parallel to midline


Mild ventriculomegaly


A communicating cyst may be seen superior to the third ventricle


Gyri are more vertically aligned and appear to radiate from lateral ventricles


Possible polyhydramnios
Asymptomatic Agenesis of corpus callosum Associated with several anomalies: Dandy-Walker syndrome, holoprosencephaly, medial facial clefts, encephalocele, or meningomyelocele, trisomy 8, 13, and 18, diaphragmatic hernia, cardiac malformations, missing or small lung(s), and renal agenesis or dysplasia



Lateral ventricle(s) appear prominent


BPD and HC within normal limits for gestational age


Ventricular atrium measures >10.0 mm in AP diameter


Choroid plexus may appear to “dangle” within dilated ventricular atrium
Asymptomatic Ventriculomegaly


Associated with aqueductal stenosis


Normal choroids should fill ventricular atrium or there should be no more than a 3-mm gap between choroid plexus and ventricle wall



Ventricles (lateral and third, possibly fourth) and fetal head size are enlarged


Brain mantle may appear thin


Falx is intact


Abnormal orbits, face, feet, and hands


Polyhydramnios
Uterus may measure large for dates Hydrocephalus


Indicates presence of obstruction (noncommunicating) in ventricular system or may be related to aqueductal stenosis, meningomyelocele, spina bifida, encephalocele, or Dandy-Walker malformation, trisomy 13 or 18


Document level or point of obstruction if possible



Ventriculomegaly (lateral and third; fourth ventricle is normal) with intact falx and preservation of brain mantle


Cerebellum and cisterna magna appear normal



Exposure to teratogens or cytomegalovirus


Maternal history of toxoplasmosis or syphilis
Aqueductal stenosis


Causes 35.7% of hydrocephalus and is more common in males (X linked)


In utero infections or intracranial tumor may be underlying cause


Mild ventriculomegaly has been associated with trisomy 21



Large cyst in posterior fossa with normal fourth ventricle not seen


Posterior fossa is enlarged


Vermis of cerebellum is not seen and hemispheres may appear splayed and flattened


Possible ventriculomegaly or hydrocephalus and agenesis of corpus callosum


Possible polyhydramnios
Uterus may measure large for dates


Dandy-Walker malformation


Enlarged cisterna magna



Associated with both intracranial and extracranial abnormalities: agenesis of corpus callosum, facial clefts, CNS, and cardiac ventricular septal defect, trisomy 13, 18, or 21


May be seen in Meckel-Gruber syndrome
Irregular cystic structure(s) noted adjacent to lateral ventricle(s); may show connection to lateral ventricle Maternal thrombocytopenia, anticoagulation therapy, drug use such as cocaine; trauma Porencephalic cyst


Rare: This finding is a result of resolved hemorrhage in parenchyma


Associated with TTTS and death of a cotwin



Fetal skull is enlarged and demonstrates bulge from top of head


Polyhydramnios
Uterus may measure large for dates Cloverleaf skull Associated with thanatophoric dysplasia, Apert syndrome, or amniotic band



Sac/mass protrudes from occipital portion of fetal skull


If the sac/mass is large, microcephaly may be present


Hydrocephalus may be seen


Microcephaly or depressed frontal bones of the skull may be noted



Asymptomatic


Labs: MSAFP may be elevated
Encephalocele


Associated with Meckel-Gruber syndrome, polydactyly, polycystic kidneys, liver cysts, cleft palate, and cardiac anomalies


An encephalocele found on the lateral aspect of the head may be caused by amniotic band


Large encephaloceles can cause microcephaly or depressed frontal cranial bones
Unable to identify normal fetal orbits Maternal history of toxoplasmosis or rubella


Microphthalmia


Anophthalmia
May be a sporadic anomaly, a result of in utero infection, trisomy 18, or Meckel-Gruber syndrome
Eyes are widely spaced Asymptomatic Hypertelorism May represent familial trait or may be related to presence of frontal encephalocele, Noonan or Crouzon syndrome
Eyes are closely spaced Asymptomatic Hypotelorism May represent familial trait or may be related to presence of holoprosencephaly, trisomy 13 or 18, or Meckel-Gruber syndrome
Single orbit is seen Asymptomatic Cyclopia Strongly associated with holoprosencephaly



Fetal chin is absent or difficult to see


Possible polyhydramnios
Uterus may measure large for dates Micrognathia


Associated with trisomy 18 and less commonly with trisomy 13


Also may be seen in other syndromes and skeletal dysplasias/dystoses



Large midline fluid-filled space with thin rim of brain tissue


Falx may or may not be present


Thalamus appears fused


May demonstrate univentricle (horseshoe-shaped ventricle); hydrocephalus
Uterus may measure large for dates


Holoprosencephaly




Alobar


Semilobar


Lobar



Difficult to differentiate semilobar from alobar


Associated findings: clubfoot, omphalocele, IUGR, and features of trisomy 13, 18, Meckel-Gruber syndrome



Agenesis of the corpus callosum, cleft lip/palate may be noted


Hypotelorism or cyclopia and proboscis may be seen


May mimic hydranencephaly



Large, fluid-filled cranium with cerebellum and midbrain seen


No brain mantle seen


Polyhdramnios
Uterus may measure large for dates


Hydranencephaly


Massive hydrocephalus



Falx may or may not be intact


May mimic alobar holoprosencephaly



A gap in soft tissue between the upper lip and nose (unilateral and bilateral)


Sweeping coronal scan plane posteriorly through fetal mouth may reveal gap in bones of upper palate


Polyhydramnios


May be unilateral or bilateral
Uterus may measure large for dates Cleft lip with/without cleft palate


Isolated or may be associated with midline cranial defects such as holoprosencephaly (midline clefts) or anencephaly


Cleft lip and palate are seen in fetuses with chromosomal defects


More commonly seen in male fetuses



Fetal tongue protrudes from mouth at all times


Polyhydramnios



Uterus may measure large for dates


Maternal diabetes
Macroglossia


Associated with Beckwith-Wiedemann syndrome, trisomy 21, omphalocele, organomegaly


Oral mass that is displacing tongue may be present



A cyst or cystic structures seen on the posterior aspect or surrounding fetal neck


Placenta may be large and edematous


Hydrops



Uterus may measure large for dates


Labs: MSAFP may be lower or higher than normal



Cystic hygroma


Teratoma


Neural tube defect


Hemangioma



Associated with Turner syndrome (45,X) and trisomy 13, 18, or 21


Note: Cystic hygromas are most commonly found in the neck but can occur in the axilla, groin, or mediastinum























Second and Third Trimester Fetal Thorax and Heart
Sonographic Finding(s) Clinical Presentation Differential Diagnosis Next Step



Fetal thorax appears narrow


Thorax to abdomen ratio is below 1:1


Polyhydramnios (skeletal disorders)


or


Oligohydramnios (renal agenesis)
Uterus measures small or large for dates


Lethal dwarfism


Pulmonary hypoplasia



Associated with many skeletal dysplasias and dystoses: thanatophoric dysplasia, achondrogenesis, and osteogenesis imperfecta type II


Also related to lack of lung development related to renal agenesis



Cystic structure in thorax, possibly displacing the heart


Polyhydramnios
Uterus may measure large for dates Bronchogenic cyst Document stomach inferior to diaphragm; if stomach is not seen in the normal location, the “cyst” may be the stomach: diaphragmatic hernia



Fluid is seen to surround one or both lungs

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