Signs in reproductive imaging



11.5: Signs in reproductive imaging


Venkatraman Indiran




Uterus




















































































Name of the Sign Description/Reason for the Appearance Image With or Without Illustration Causes and Significance

Bridging vessel sign


Multiple vascular channels (white arrows) connecting uterus (black arrow) to an adjacent pelvic mass on imaging studies, is known as the ‘bridging vessel’ or ‘bridging vascular’ sign.


Originally described on colour Doppler imaging, but also seen on computed tomography (CT) or magnetic resonance imaging (MRI).


Image

Helps in differentiating a mass of uterine origin, typically a subserosal fibroid, from other pelvic masses.


Sensitivity and specificity of ‘bridging vessel sign’ in identifying subserosal fibroids range from 90% to 100%. (Best seen when subserosal fibroid is larger than 3 cm in diameter.)


Ovarian masses invading the uterus may rarely produce a falsely positive bridging vessel sign.


Broccoli sign


Submucosal uterine leiomyoma prolapsing into the endocervical canal, along with its stalk in the uterine cavity on sagittal T2-weighted images together is called as ‘broccoli sign’ (white arrow).


Image

Submucosal uterine leiomyoma


Bunch of grapes


Intrauterine mass with cystic spaces without any associated foetal parts on ultrasound (white arrows) classically gives a ‘snow storm’ or ‘bunch of grapes’ appearance.


Image

Complete hydatidiform mole


Hourglass sign


Deep infiltrating endometriosis (DIE) affecting the posterior urinary bladder wall, usually in the midline, causes loss of its distensibility, resulting an hourglass configuration of urinary bladder.



Deep infiltrating endometriosis (DIE)


Hyperechoic line sign


Normal endometrium surrounding the endometrial polyp on ultrasound appear as a hyperechoic rim on transvaginal ultrasound is called as ‘hyperechoic line sign’.


Hyperechoic line sign represents a focal intracavitary lesion.



Endometrial polyp


Indian head dress sign/moose antler sign


In deep infiltrating endometriosis (DIE), adhesions between the anterior wall of rectosigmoid and posterior wall of uterus, stretches the muscular layer of the bowel and creates an infiltrative nodule with parallel lines that extend from the adhesion to the rectosigmoid. This is called as ‘Indian head dress sign/moose antler sign’ (white arrow). This is seen on sagittal T2-weighted images as well as transvaginal ultrasound.


Image

Deep infiltrating endometriosis (DIE)


Interstitial line sign


An echogenic line that extends into the upper regions of the uterine horn and borders the margin of the intramural gestational sac is called as the ‘interstitial line sign’ (white arrow).


Seen best on transabdominal/transvaginal ultrasound.


Image

Specific finding of interstitial pregnancy


Mushroom cap sign


Mushroom-shaped lesion which is seen displaced into the bowel lumen in patients with solid invasive endometriosis of the rectosigmoid colon on axial or sagittal T2-weighted MRI is called as ‘mushroom cap sign’ (red box and white arrow).


Low signal intensity base of the mushroom corresponds to hypertrophy and fibrosis of the muscularis propria, whereas the high intensity cap represents oedematous mucosa and submucosa.


Image

Deep infiltrating endometriosis (DIE)


Pedicle artery sign


Feeding vessel sign


Central vessel entering the endometrium from the surrounding myometrium colour Doppler imaging of the endometrium in endometrial polyps is called as pedicle artery sign (white arrow).


Image

Endometrial polyps in women with postmenopausal bleeding.


(Sensitivity of 76.5%; specificity of 95.3%.)


Popcorn ball calcification


Dense, amorphous calcifications of uterine fibroids seen on the plain radiographs is called as ‘popcorn calcification’ (white arrow).


Image

Confluent, coarse calcification constitutes the most specific radiographic sign of a benign uterine fibroid; but only 10% or fewer of fibroids show calcification.


Question mark sign of uterus


The uterine corpus that is flexed backward with the fundus of the uterus facing the posterior pelvic compartment and the cervix directed anteriorly toward the urinary bladder, is called as question mark sign of uterus (white arrow).


Also called as comma-shaped uterus.


Image

93% specificity and 75% sensitivity in diagnosing adenomyosis uterus.


Sliding organs’ sign


When the uterus and ovaries glide freely over the posterior and anterior organs (such as rectum and urinary bladder, respectively) during real-time dynamic transvaginal sonography, it is called as ‘positive sliding organs’ sign’.



In case of adhesions due to endometriosis, free gliding of organs is absent and is called as negative sliding sign.


Snowstorm sign


Grainy appearance with low-level homogeneous internal echoes which move slowly downward due to their viscosity seen in endometrioma on transvaginal ultrasound is called as snowstorm sign.



Endometriomas


Split fibre sign


Presence of curvilinear T2 hypointense strands within the degenerated leiomyoma separated by the fluid accumulation and oedema is called as the ‘split fibre’ sign.


Image

Split fibre sign on T2-weighted MRI can be used to differentiate hydropic degeneration from other conditions like malignant change.


Three-line sign or triple line sign or trilaminar appearance


Shortly before ovulation, two additional bright linear echoes outline two hypoechoic layers of endometrium with a central hyperechoic line in the endometrium (white arrow). It is called as the ‘three-line sign’ or ‘triple line sign’ or trilaminar appearance.


Image

A triple-line pattern with a moderate endometrial thickness is associated with a good clinical outcome on in-vitro fertilization.


Venetian blind shadowing


Also known as ‘rain shower’ appearance


Heterogeneous myometrial appearance due to hyperechoic heterotopic endometrial tissue and hypoechoic hyperplastic smooth muscle appearing as vertical linear bands of shadows on ultrasound is called as ‘Venetian blind shadowing’.



Classically described in uterine adenomyosis; sometimes in uterine fibroids also.




Fallopian Tubes














































Sign Explanation Image Cause

Bead on strings sign


Thickened endosalpingeal longitudinal folds within a dilated fallopian tube without wall thickening appears as small mural nodules on cross-sectional images on ultrasound is called as ‘bead on strings’ appearance.



Seen in chronic salpingitis


Beaded tube


Multiple constrictions along the course of fallopian tube may form due to scarring is seen in genitourinary tuberculosis and shows a ‘beaded’ appearance.



Female genital tuberculosis


Cogwheel sign


Thickened endosalpingeal longitudinal folds within a dilated fallopian tube with thickened wall appears as small mural nodules on cross-sectional images across the long axis of the fallopian tube on ultrasound (white arrows) produce a characteristic ‘cogwheel’ appearance.


Image

Seen in acute salpingitis.


The presence of thickened longitudinal folds is pathognomonic for hydrosalpinx.


Cobblestone tube


Rounded filling defects in cases of fallopian tube tuberculosis are called as the cobblestone pattern.


Is an effective radiographic sign of intraluminal scarring and adhesions.



Female genital tuberculosis


Golf club tube


Occlusion of the isthmus or fimbrial end of the fallopian tube and filling up of the tube with serous or clear fluid produces a moderate dilatation at the fimbrial end, produces a ‘golf club–like appearance’.



Female genital tuberculosis


Halo sign


Thin radiolucency seen separating the loculated peritubal collection from the dilated tube, is known as the ‘halo sign’. This radiolucent halo represents the thickened wall of the tube.



Female genital tuberculosis


Incomplete septation sign


Thin linear structures appearing to protrude into the tubular cystic adnexal structures, but not touching the opposite walls is called ‘incomplete septation sign’ of hydrosalpinx.


Apparent septae are due to apposition of the inner walls of the dilated and folded fallopian tube.



Hydrosalpinx


Pipe stem tube


Rigid contour of the fallopian tube seen in cases of fallopian tube tuberculosis is called as ‘pipe stem appearance’.



Female genital tuberculosis


Leash sign


Typical eccentric leash of vessels on colour Doppler (white arrow) showing a low resistance placental type of flow on spectral Doppler in fallopian tube ectopic pregnancies is called as leash sign.


Image

Only gold members can continue reading. Log In or Register to continue

Stay updated, free articles. Join our Telegram channel

Mar 15, 2026 | Posted by in OBSTETRICS & GYNAECOLOGY IMAGING | Comments Off on Signs in reproductive imaging

Full access? Get Clinical Tree

Get Clinical Tree app for offline access