Sinonasal Chondrosarcoma
Michelle A. Michel, MD
Key Facts
Imaging
Arises from maxilla, nasal septum, & skull base
Nasal septum location: Posterosuperior vomer
Bone CT: Chondroid matrix calcification & narrow bony transition zone
50% with chondroid matrix
MR: Increased (high) signal on long TR images & heterogeneous enhancement
Top Differential Diagnoses
Sinonasal osteosarcoma
Skull base meningioma
Sinonasal ossifying fibroma
Sinonasal fibrous dysplasia
Esthesioneuroblastoma
Pathology
Malignant neoplasm arising from chondrocytes, embryonal rests, or mesenchymal cells
May complicate Ollier & Maffucci syndromes
Clinical Issues
Presents in 5th-7th decades
Duration from symptom onset to diagnosis: 3 months to 1 year
Accounts for 0.1% of H&N cancers
Surgical resection is primary treatment modality
Difficult to achieve oncologic resection due to proximity of vital structures
Late recurrences after long disease-free periods are reported; long-term follow-up advised
Overall 5-year survival: 54-81%Related posts:
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