Parameter
Non-exposure
Low exposure
High exposure
p
(n = 107)
(n = 93)
(n = 105)
Gender
Male
90
78
85
0.797
Female
17
15
20
Age (year)
57.1 ± 12.0
56.7 ± 10.8
56.4 ± 11.3
0.996
Number of lesions
1
89
72
84
0.546
2
15
19
16
3
3
2
5
Maximum diameter (cm)
2.6 ± 1.1
2.7 ± 1.3
2.8 ± 1.3
0.802
Liver diseases
HBV
90
83
88
0.052
HCV
13
8
12
Other
4
2
5
Child–Pugh classification
A
97
83
93
0.485
B
10
10
12
).
15.3.1 Recurrence and Metastasis
The recurrence and metastasis rate in the high, low and non-exposure groups were 61.9 % (65/105), 50.5 % (47/93), and 69.2 % (74/107) respectively. The 1- and 2-year recurrence and metastasis rates are shown in Table 15.2. In the low-exposure group, the rates were significantly lower than in the non-exposure group (p = 0.014 and 0.009). In the high-exposure group, the 1-year recurrence and metastasis rates were significantly lower than in the non-exposure group (p = 0.025), while there was no significant difference in the 2-year recurrence and metastasis rates, though a decrease trend was detected (p = 0.131). There was no significant difference between the high- and low-exposure groups in 1- and 2-year recurrence and metastasis rates (p = 0.880 and 0.306).
Table 15.2
The 1-, 2-year recurrence and metastasis rate of different cohort
Cohort | 1-year | 2-year |
|---|---|---|
Non-exposure | 50.5 % (54/107) | 63.6 % (68/107) |
Low-exposure | 32.3 % (30/93)a | 44.1 % (41/93)c |
High-exposure | 34.3 % (36/105)b | 52.4 % (55/105) |
15.3.2 Survival
The 1-, 2- and 3-year cumulative survival rates of each group are shown in Table 15.3. There was no significant difference in the 1-year OS rate among the three groups (all OS > 90 %, p > 0.05). It was detected that the 2- and 3-year OS rates of the high-exposure group were significant higher than in the non-exposure group (p = 0.000, p = 0.043). Different survival curves of exposure factors are shown in Fig. 15.1.
Table 15.3
The 1-, 2- and 3-year cumulative survival rate of different cohort
Cohort | 1-year | 2-year | 3-year |
|---|---|---|---|
Non-exposure (%) | 90.7 | 70.1 | 64.4 |
Low-exposure (%) | 90.5 | 81.7 | 72.0 |
High-exposure (%) | 93.3 | 84.8a | 77.1b |
Fig. 15.1
The OS rate of the high exposure group was significant higher than the non-exposure group (p = 0.002). There was no significant difference between the high- and low-exposure groups (p = 0.080), and there was also no significant difference between the low- and non-exposure groups (p = 0.208)
15.3.3 Cox Multivariate Regression Analysis of Disease-Free Survival
The data of gender, age, number of lesions, lesion size, the maximum diameter, the type of liver disease, Child–Pugh classification, exposure factors, and disease-free survival time were analyzed by Cox multivariate regression analysis, and are listed in Table 15.4.
Table 15.4
Multi-factor Cox multivariate regression analysis with disease-free survival time
Factor | B | SE | Wald | Sig. | Exp(B) | 95.0 % CI for Exp(B) | |
|---|---|---|---|---|---|---|---|
Lower | Upper | ||||||
Exposure factor | −0.434 | 0.193 | 5.076 | 0.024 | 0.648 | 0.444 | 0.945 |
Age | 0.007 | 0.007 | 1.033 | 0.309 | 1.007 | 0.994 | 1.020 |
Gender | 0.070 | 0.205 | 0.115 | 0.734 | 1.072 | 0.717 | 1.603 |
Liver diseases | 0.383 | 0.277 | 1.910 | 0.167 | 1.467 | 0.852 | 2.524 |
Number of lesions | 0.139
Related posts: Microwave Ablation Combined with Cellular Immunotherapy for Hepatocellular Carcinoma
 Microwave Ablation for Malignant Liver Tumors Adjacent to the Hepatic Hilum
 Ultrasound-Guided Microwave Ablation for Superficial Malignant Tumors
 Microwave Ablation for Adenomyosis
 Clinical Application of Three-Dimensional Visualization Techniques in Microwave Ablation for Liver Cancer
 Microwave Ablation in Renal Cell Carcinoma
 Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
Get Clinical Tree app for offline access
| ||||||