KEY FACTS
Terminology
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Occlusion of transplant renal artery secondary to thrombus
Imaging
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Edematous hypoechoic kidney if total thrombosis
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Absence of blood flow in main renal artery
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Diffuse absence of parenchymal perfusion on color or power Doppler
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Blunted low-resistance waveforms in ischemic areas from collateral flow
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If involving accessory renal artery
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Segmental wedge-shaped peripheral area of decreased color flow and altered echogenicity
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Color, power, spectral Doppler US 1st-line imaging modality for complications of renal transplantation
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Optimize color and spectral Doppler settings for slow flow
Top Differential Diagnoses
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Transplant renal vein thrombosis
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Acute rejection/acute on chronic rejection
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Hyperacute rejection
Clinical Issues
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Rare (< 1%)
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Abrupt onset of oliguria, decreased function, pain and swelling of allograft
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Poor prognosis; graft loss typical when single main artery thrombosed
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Transplant nephrectomy
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Thrombectomy or thrombolysis rarely successful unless diagnosis made early
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Accessory or segmental arterial thrombosis → ischemia and subsequent atrophy
Diagnostic Checklist
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Severe acute rejection or tubular necrosis may cause propagating small vessel thrombosis resulting in infarction and mimicking transplant renal artery thrombosis
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Urgent finding requiring prompt communication