CASE 133 History: A 20-year-old woman presents with a history of neck pain and decreased range of motion for the past year and shooting pain in the arms for the past few months. 1. What should be included in the differential diagnosis? (Choose all that apply.) a. Chordoma b. Metastasis 2. What is the most common location of giant cell tumor involving the spine? c. Lumbar spine d. Sacral spine 3. All of the following imaging features are helpful in differentiating giant cell tumor from other etiologies except: a. Location within the vertebral body b. Sparing of the intervertebral disk space c. Extension into the prevertebral soft tissues d. Hypointense signal on T2-weighted images relative to the cord 4. What is the estimated frequency of malignant giant cell tumors or malignant transformation of benign giant cell tumors? a. Less than 1% b. 10% c. 25%
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