(A) Axial and coronal FDG-PET images demonstrate a markedly hypermetabolic lesion in the right mid lung (arrow). (B) Corresponding axial CT image demonstrates a wedge-shaped consolidative lesion that is sharply marginated posteriorly with adjacent ground-glass anteriorly (arrow).

Differential Diagnosis

•  Acute pneumonia: Segmental consolidation on CT is suggestive of infection, particularly given the history. Active infection will have increased FDG accumulation on PET.

•  Synchronous lung carcinoma: This is a possible etiology. Follow-up chest radiography or CT should be performed after antibiotic treatment to demonstrate lesion resolution.

•  Colon cancer metastatic to lung: This will also be hypermetabolic on FDG-PET but is typically more nodular on CT.