Adrenal Glands


A.  Adrenal protocol CT


C.  Surgical referral

D.  Medical management

  2    Attenuation measurements are the cornerstone of adrenal nodule characterization with CT. Which of the following adjustments will have the greatest effect on measured CT attenuation 1 minute after the administration of intravenous iopamidol 300 in a scan obtained and reconstructed with the following parameters: 120 kVp, 200 fixed mA, 5-mm collimation, and filtered back projection?

A.  Enabling statistical iterative reconstruction

B.  Increasing the mA from 200 to 400

C.  Decreasing the kVp from 120 to 80

D.  Exchanging iopamidol 300 for iohexol 300

  3    A 50-year-old male with history of clear cell renal cell carcinoma status post–left nephrectomy presents for characterization of a right adrenal nodule detected on follow-up imaging. Images represent dual-echo gradient-recalled echo T1-weighted imaging with the following echo times at 1.5 Tesla: 2.2 msec (image on LEFT) and 4.4 msec (image on RIGHT). Signal intensity measurements within the adrenal mass are as follows: 144 (image on LEFT) and 175 (image on RIGHT) (18% signal loss). If there are no comparison studies, what is the best next step?



A.  Tissue sampling

B.  Follow-up in 12 months

C.  Ignore (benign finding)

D.  Adrenal protocol CT

  4    A 63-year-old female with a history of gastric cancer presents for characterization of a 3.3-cm adrenal mass. There are no comparison images. Regions of interest drawn in the center of the mass on triphasic adrenal protocol CT are as follows: (a) unenhanced: 16 Hounsfield units; (b) 1-minute delay: 55 Hounsfield units; and (c) 15-minute delay: 28 Hounsfield units. What is the calculated absolute percent washout?


A.  29%

B.  49%

C.  69%

D.  89%

  5    A 54-year-old female with node-positive invasive lobular breast cancer has a 2.1-cm homogeneous right adrenal mass. Adrenal protocol CT is performed utilizing 1-minute and 15-minute delays. Relative washout is calculated to be 50%. Which of the following is the most likely diagnosis?

A.  Pheochromocytoma

B.  Metastasis

C.  Adenoma

D.  Adrenocortical carcinoma

  6    A 60-year-old male with hypertension and right lower quadrant pain undergoes a CT of the abdomen and pelvis to rule out appendicitis. An incidental 1.5-cm homogeneous right adrenal mass is identified. He has no other relevant medical history. What is the estimated risk that this adrenal nodule is malignant?

A.  1 in 5

B.  1 in 50

C.  1 in 500

D.  <1 in 1,000

  7    A 65-year-old male ICU patient with a complicated medical history presents with new findings in the adrenal glands. The unenhanced CT image on the left was obtained 2 weeks after the unenhanced CT image on the right. What is the best next step?



A.  Adrenal protocol CT

B.  Percutaneous biopsy

C.  Medical management

D.  Follow-up in 6 to 12 months

  8    A 40-year-old female with postprandial pain and no other past medical history undergoes a right upper quadrant ultrasound. The gallbladder and biliary tree are normal, but an incidental 2.0-cm mass is identified in the right suprarenal fossa. An abdominal MRI follows confirming that the mass arises from the right adrenal gland. India ink artifact is observed within the mass encircling a 1.2-cm internal nodule. What is the most likely diagnosis?

A.  Pheochromocytoma

B.  Myelolipoma

C.  Collision tumor

D.  Adrenocortical carcinoma

  9    A 23-year-old female with MEN-IIb syndrome and hypertension presents for an I123-MIBG scan. In which of the following organs is uptake on an I123-MIBG scan always abnormal?

A.  Myocardium

B.  Salivary glands

C.  Adrenal glands

D.  Bones

E.  Colon

  10    A 25-year-old male with a hereditary paraganglioma–pheochromocytoma syndrome undergoes an I123-MIBG study. What is the best diagnosis?


A.  Myocarditis

B.  Hepatic metastatic disease

C.  Normal study

D.  Nodal metastatic disease (neck)

  11    T1-weighted dual-echo gradient-recalled echo imaging is used for the detection of intracellular lipid and macroscopic fat. With this sequence, when fat and water protons are out of phase, fat protons are shifted a certain distance along the frequency-encoding axis depending on the receiver bandwidth and field strength. What is the approximate calculated fat/water chemical shift at 1.5 Tesla? Use the following formula:


A.  85 Hz

B.  220 Hz

C.  440 Hz

D.  550 Hz

  12    A 56-year-old male with no history of malignancy and suspected primary hyperaldosteronism undergoes an adrenal protocol CT demonstrating a 1.5-cm left adrenal nodule with 70% absolute washout. The right adrenal gland is normal. What is the best next step?


A.  Adrenal protocol MRI

B.  Left adrenalectomy

C.  Percutaneous biopsy

D.  Adrenal vein sampling

  13    A 59-year-old female with suspected primary hyperaldosteronism and a 1.3-cm unilateral left adrenal nodule undergoes adrenal vein sampling. Which description best characterizes the adrenal venous anatomy?



A.  Right: A single vein drains into the IVC; Left: A single vein drains into the left renal vein.

B.  Right: Three veins drain into the IVC; Left: Three veins drain into the left renal vein.

C.  Right: A single vein drains into the right renal vein; Left: A single vein drains into the IVC.

D.  Right: Three veins drain into the right renal vein; Left: Three veins drain into the IVC.

  14    A 55-year-old male with non–small cell lung cancer and a 1.5-cm homogeneous right adrenal nodule presents for triphasic adrenal protocol CT. Which of the following image–time combinations has been shown to be most effective for adrenal nodule characterization?

A.  Unenhanced, 1 minute postcontrast, 20 minutes postcontrast

B.  Unenhanced, 1 minute postcontrast, 15 minutes postcontrast

C.  Unenhanced, 1 minute postcontrast, 10 minutes postcontrast

D.  Unenhanced, 1 minute postcontrast, 5 minutes postcontrast

  15    A 62-year-old female with invasive ductal carcinoma of the breast and an indeterminate 1.5-cm left adrenal nodule undergoes a staging PET study. Which of the following adrenal nodule characteristics has the highest negative predictive value for metastasis?

A.  Standardized uptake value (SUV) maximum >5

B.  Standardized uptake value (SUV) maximum <5

C.  Qualitative uptake greater than background liver

D.  Qualitative uptake less than background liver

  16    A 38-year-old female with early-onset diabetes mellitus presents with a dark rash covering her neck and armpits. CT imaging is performed and demonstrates a 4.9-cm left adrenal mass. An image representative of the entire mass is shown below. The patient has no history of malignancy. What is the best next step?


A.  Adrenal protocol CT

B.  Adrenal protocol MRI

C.  Percutaneous biopsy

D.  Open surgical resection

  17    One of the fundamental sequences of adrenal protocol MR is T1-weighted dual-echo gradient-recalled echo imaging for the detection of intracellular lipid and macroscopic fat. Which of the following correctly describes a difference between gradient echo imaging and spin echo imaging?

A.  Gradient echo imaging usually has a longer TR.

B.  Gradient echo imaging usually has a larger flip angle.

C.  Gradient echo imaging has a refocusing RF pulse, and spin echo imaging does not.

D.  Gradient echo imaging is more affected by residual transverse magnetization.

  18    A 70-year-old female with lung cancer and an indeterminate 2.2-cm left adrenal mass presents for percutaneous biopsy. Which of the following positional maneuvers will most effectively reduce the risk of pneumothorax during the biopsy while minimizing risk to other structures?

A.  Decubitus, ipsilateral side down

B.  Decubitus, contralateral side down

C.  Prone

D.  Supine

  19    A 32-year-old male (body mass index: 22 kg/m2) with intermittent diaphoresis, palpitations, and early-onset hypertension (190/110) presents for adrenal protocol CT. What is the serious adverse event risk of administering intravenous low-osmolality iodinated contrast material to a patient with pheochromocytoma who is not receiving alpha- and beta-blockade?

A.  80% chance of a serious adverse event

B.  30% chance of a serious adverse event

C.  5% chance of a serious adverse event

D.  <1% chance of a serious adverse event

  20    A 62-year-old male with clinical-stage T1cN0Mx Gleason 5 + 4 = 9 prostate cancer and no signs of adrenal hyperactivity presents for MR characterization of a 2.4-cm right adrenal nodule. Images represent dual-echo gradient-recalled echo T1-weighted imaging with the following echo times at 1.5 Tesla: 2.2 msec (image on left) and 4.4 msec (image on right). What is the best next step?



A.  Ignore (benign finding)

B.  Adrenal protocol CT

C.  Percutaneous biopsy

D.  Right adrenalectomy

  21    Homogeneous loss of signal intensity within an adrenal nodule <4 cm on opposed-phase T1-weighted dual-echo gradient-recalled echo imaging is compatible with an adrenal adenoma in most cases. What organ is best used as an internal reference standard to determine the degree of signal loss within an adrenal nodule?

A.  Liver

B.  Pancreas

C.  Kidney

D.  Spleen

  22    A 60-year-old female with right lower quadrant abdominal pain undergoes a CT of the abdomen and pelvis demonstrating perforated appendicitis and an incidental finding in the left adrenal gland. The following image is representative of the entire gland. Which of the following is most strongly associated with this abnormality?


A.  Hemangioblastoma

B.  Renal agenesis

C.  Pheochromocytoma

D.  Polysplenia

  23    A 58-year-old male with mild hypertension (140/90) managed with one medication and no history of malignancy undergoes an abdominal MRI that shows a 3.2-cm enhancing mass in the right adrenal gland. No intracellular lipid or macroscopic fat is identified. The left adrenal gland is normal, and the patient is asymptomatic. What is the best next step?



A.  Right adrenalectomy

B.  Alpha- and beta-adrenergic blockade

C.  Percutaneous biopsy

D.  Laboratory evaluation

  24    A 45-year-old male with a right adrenal myelolipoma undergoes MR imaging. The following T2-weighted images were acquired without (left) and with (right) a conventional inversion recovery technique. Along what vector do the protons align in conventional inversion recovery imaging immediately following the preparation radiofrequency pulse (applied before the excitation pulse)?



A.  0 degrees (with main magnetic field)

B.  90 degrees (perpendicular to main magnetic field)

C.  180 degrees (opposed to main magnetic field)

D.  270 degrees (perpendicular to main magnetic field)

  25    A 51-year-old male with no comparison imaging and a recently diagnosed obstructing sigmoid colon cancer presents for staging CT of the chest, abdomen, and pelvis. Imaging demonstrates the known colon mass, enlarged regional lymph nodes, and a 2.2-cm left suprarenal abnormality. What is the best next step?


A.  Adrenal protocol CT

B.  Biopsy

C.  Aspiration

D.  Ignore (benign finding)

  26    A 28-year-old male with suspected pheochromocytoma is scheduled to undergo an I131-MIBG scan to confirm the diagnosis and evaluate for distant disease. Which organ is at greatest risk of radiation-induced carcinogenesis if no precautionary measures are taken?

A.  Adrenal glands

B.  Spleen

C.  Myocardium

D.  Thyroid

  27    A 4-year-old girl with recurrent abdominal pain and unexplained fevers presents with a right suprarenal mass. What is the most likely diagnosis?




A.  Sarcoma

B.  Neuroblastoma

C.  Adrenocortical carcinoma

D.  Pheochromocytoma

  28    Where is the organ of Zuckerkandl?

A.  Near the carotid bifurcation

B.  Near the aortic bifurcation

C.  Within the middle ear

D.  Along the urinary bladder wall

  29    Pheochromocytoma is associated with several tumor-forming genetic syndromes. Which of the following is an example of that?

A.  Multiple endocrine neoplasia (MEN) type I

B.  Beckwith-Wiedemann syndrome

C.  Neurofibromatosis type I

D.  Hereditary leiomyomatosis renal cell cancer (HLRCC) syndrome

  30    A 75-year-old male with altered mental status undergoes an abdominopelvic CT examination that demonstrates an abnormal left adrenal gland. The right adrenal gland is normal. Which of the following best explains this imaging finding?


A.  Pheochromocytoma

B.  Metastasis

C.  Remote hemorrhage

D.  Adrenocortical carcinoma

Answers and Explanations

  1    Answer D. Large, bulky, bilateral macroscopic fat-containing adrenal masses is indicative of adrenal myelolipomas in the setting of congenital adrenal hyperplasia (CAH). These patients require medical management for their endocrine abnormalities. The most common cause of CAH is 21-hydroxylase deficiency, which results in salt wasting, female virilization, and hyperandrogenism. Most patients with 21-hydroxylase deficiency are detected during newborn screening. Adrenal protocol CT is not indicated for adrenal masses that contain macroscopic fat because it will add no additional information. PET and/or operative referral are not indicated because the masses are not malignant.

References: German-Mena E, Zibari GB, Levine SN. Adrenal myelolipomas in patients with congenital adrenal hyperplasia: review of the literature and a case report. Endocr Pract 2011;17:441447.

Nermoen I, Rorvik J, Holmedal SH, et al. High frequency of adrenal myelolipomas and testicular adrenal rest tumours in adult Norwegian patients with classical congenital adrenal hyperplasia because of 21-hyroxylase deficiency. Clin Endocrinol 2011;75:753759.

  2    Answer C. Changing kVp has a direct effect on CT number measurements. Higher kVp imaging, particularly with multidetector CT, is susceptible to artificial increases in measured attenuation due to “pseudoenhancement” effects. Lower kVp imaging is closer to the k-edge of iodine, resulting in increased attenuation at lower kVp within iodine-containing (i.e., enhanced) structures. This fact is often exploited for high-contrast examinations like CT angiography. Lower kVp imaging is associated with greater image noise, less radiation dose, and greater measured iodine attenuation than higher kVp imaging. Changing mA, enabling statistical iterative reconstruction, and/or switching between contrast agents with similar iodine concentrations will have a negligible effect on CT number measurements.

References: Kaza RK, Platt JF, Goodsitt MM, et al. Emerging techniques for dose optimization in abdominal CT. Radiographics 2014;34:417.

Wang ZJ, Coakley FV, Fu Y, et al. Renal cyst pseudoenhancement at multidetector CT: what are the effects of number of detectors and peak tube voltage? Radiology 2008;248:910916.

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Apr 20, 2017 | Posted by in GENITOURINARY IMAGING | Comments Off on Adrenal Glands

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