• The breast lies on the chest wall and on the deep pectoral fascia the superficial pectoral fascia envelops the breast suspensory ligaments (Cooper’s ligaments) connect the two layers Collecting ducts open onto the tip of the nipple Sebaceous glands within the nipple–areolar complex are called Montgomery’s glands ducts open onto the skin surface (and are seen as small raised nodular structures called Morgagni’s tubercles) This is divided into 15–25 lobes, each consisting of a branching duct system leading from the collecting ducts to the terminal duct lobular units (TDLUs) Each duct drains a lobe made up of 20–40 lobules Young women usually have dense glandular breast tissue this is usually replaced by fatty tissues in older women with loss of the lobular units Lymphatic drainage is usually to the axillary and internal mammary nodes • High spatial resolution is required to detect microcalcification: a short exposure time limits any movement artefact it requires a very small focal spot (0.1–0.3mm) grids are used to reduce scatter and increase contrast digital mammography is now used • There is a narrow range of inherent breast densities (as it is predominantly fatty tissue): low molybdenum energy peaks (17.5 and 19.6keV) provide high contrast (filtering reduces extraneous radiation) • Breast compression: this reduces geometric and movement unsharpness it improves contrast (it reduces scatter) it reduces radiation dose (less tissue needs to be penetrated) it achieves uniform image density it separates superimposed breast tissues it highlights rigid tumours (glandular tissue is compressible) Evaluation of breast symptoms and signs, including masses, skin thickening, deformity, nipple retraction, nipple discharge and nipple eczema Follow-up of breast cancer patients Guidance for biopsy or localization of lesions not visible on ultrasound • Mediolateral oblique (MLO) view (standard): The XR beam is directed from superomedial to inferolateral (usually at 30–60°) compression is applied obliquely across the chest wall and perpendicular to the long-axis pectoralis major The only view demonstrating the entire breast tissue on a single image Well positioned if: the inframammary angle is demonstrated the nipple is in profile the nipple is positioned at the level of the lower border of the pectoralis major, with the muscle across the posterior border of the film at 25–30° to the vertical • Craniocaudal (CC) view (standard): The XR beam travels from superior to inferior the breast is pulled forward and away from the chest wall with compression applied from above Well positioned if: the nipple is in profile it demonstrates virtually all of the medial tissue and the majority of the lateral tissue (with exclusion of the axillary tail of the breast) the depth of breast tissue should be < 1cm of the distance from the nipple to the pectoralis major on the MLO projection • Paddle views (supplementary): Localized compression applied with a compression paddle It distinguishes a real lesion from superimposition of normal tissues it defines the margins of a mass • True lateral view (supplementary): The mammography unit is turned through 90° and a mediolateral or lateromedial XR beam used It distinguishes superimposition of normal structures from real lesions it increases the accuracy of wire localizations of non-palpable lesions • Magnification views (supplementary): Performed in the craniocaudal and lateral projections These interrogate areas of microcalcification and can demonstrate ‘teacups’ with benign calcification • Eklund technique (supplementary): • Exaggeration of the normal cyclical proliferation and involution of breast tissue with the development of fibrosis regression with pregnancy and menopause increased risk for developing certain types of cancer (e.g. ductal carcinoma in situ (DCIS)) • A benign tumour arising from the TDLU (fibrous stroma + epithelial ductal structures) it often enlarges during pregnancy and regresses after the menopause it is the most common cause of a benign solid mass in the breast • Requires biopsy for diagnosis unless <25 years old (to exclude malignancy) • Juvenile fibroadenoma: a more cellular variant occurring at a younger age • Phyllodes tumour: a fibroepithelial tumour similar to a giant fibroadenoma, affecting an older age group < 25% are locally aggressive requiring clear surgical margins large fibroadenomas or those rapidly increasing in size are excised to avoid missing a phyllodes tumour
Breast
NORMAL ANATOMY
2 components
METHODS OF IMAGING
Imaging in mammography
Mammography (digital/analogue) (MMG)
INTRODUCTION
FIBROCYSTIC CHANGE
DEFINITION
BENIGN MASS LESIONS
FIBROADENOMA
DEFINITION
RADIOLOGICAL FEATURES
US