Delayed Renal Graft Function





KEY FACTS


Terminology





  • Need for dialysis or failure of serum creatinine to halve in 1st week after transplantation



Imaging





  • Clinical diagnosis with no specific imaging findings



  • Renal transplant may be edematous



  • Ultrasound with Doppler serves to exclude other causes of renal transplant dysfunction




    • Look for hemorrhage, vascular thrombosis, or hydronephrosis




  • Resistive indices may be elevated or there may be absence of diastolic flow



Pathology





  • 21% incidence in deceased donor transplantation



  • 2-5% after living donor transplantation



  • Most common cause is acute tubular necrosis: 70-90%



  • Risk factors




    • Donor age, harvest injury, preservation



    • Injury at procurement, organ preservation methods, warm and cold ischemia time




Clinical Issues





  • Present with oliguria, lack of renal function



  • Delayed graft function has significant impact on long-term graft and patient survival



  • Increased incidence of acute rejection



  • May be complicated by vascular thrombosis



  • Treatment is supportive with dialysis as indicated



Scanning Tips





  • Determine vascular patency, exclude ureteral obstruction and collections



  • Use ultrasound to guide renal transplant biopsy




Nov 10, 2024 | Posted by in ULTRASONOGRAPHY | Comments Off on Delayed Renal Graft Function

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