Dorsolateral Prefrontal Cortex (Areas 9, 46)

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Dorsolateral Prefrontal Cortex (Areas 9, 46)

Main Text

Location and Boundaries

Location

• Middle frontal gyrus
• Middle portion (medial and lateral) of superior frontal gyrus

Boundaries

• Rostral: Frontal pole
• Caudal: Caudal portion of middle frontal gyrus
• Lateral and ventral: Inferior frontal sulcus
• Medial and dorsal: Cingulate sulcus
• Surrounded by frontal pole (area 10), inferior frontal gyrus (areas 44, 45, and 47), premotor cortex (area 6), superior prefrontal cortex (area 8), and anterior cingulate cortex (area 32)

Function

Memory

• Encoding and retrieval stages of familiar stimuli during working memory
• Updating items retained during working memory
• Retaining items held in memory in presence of distraction

Planning

• Ordering events appropriately to complete task

Decision Making

• Pattern recognition and comparison
• Analyzing risk in potential decisions

Structural Connections

Cortical Connections

• Inferior parietal lobule (areas 39, 40)
• Premotor cortex (area 6)
• Superior temporal gyrus (area 22)
• Orbitofrontal cortex (area 11)

Subcortical Connections

• Mediodorsal nucleus of thalamus
• Basal ganglia
• Hippocampus
• Ventral tegmental area

Functional Connections

Coactive Regions

• Superior prefrontal cortex (area 8)
• Anterior insula (area 13)
• Thalamus
• Basal ganglia
• Superior parietal cortex (areas 5, 7)
- Intraparietal sulcus
- Precuneus
• Inferior parietal lobule (areas 39, 40)
- Supramarginal gyrus (area 40)
- Angular gyrus (area 39)
• Cingulate cortex (areas 23, 24, 31, 32, and 33)

Associated Literature Keywords (NeuroSynth)

• Execution, preparation, monitoring, planning, sequence, imagery, movements, working memory, outcome, counting

Areas 9- and 46-Associated Disorders

Major Depressive Disorder

• Common site of stimulation when treating depression with repetitive transcranial magnetic stimulation
• Hypoactivity normalized by antidepressant medication

Posttraumatic Stress Disorder

• Hypoactive in patients when anticipating negative experience

Schizophrenia

• Increased activity predicts better patient response to cognitive behavioral therapy
• Practice-induced decrease in dorsolateral prefrontal activity in patients

Addiction

• Dorsolateral prefrontal cortex modulates brain regions responsible for assigning value to rewarding stimulus in smokers

Image Gallery

Print Images

COACTIVATION OF DORSOLATERAL PREFRONTAL CORTEX

Axial and sagittal slices show the relative positions of dorsal prefrontal cortex area 9 and area 46 (data source: WFU PickAtlas).

Coactivation map of Brodmann areas 9 and 46 shows brain regions that reliably activate with the centroid of voxels lying within areas 9 and 46 in > 4,000 studies from the NeuroSynth database. Image is the average of left and right coactivation maps.

CONNECTIVITY TO DORSOLATERAL PREFRONTAL CORTEX

Functional connectivity MR images are shown, averaged from 1,016 typically developing volunteers (ages 18-30) from the 1,000 Functional Connectomes and ADHD-200 datasets. The image shows correlation to a seed region in bilateral Brodmann area 46, as defined by the WFU PickAtlas toolbox for MATLAB. Image was created using BrainNet Viewer software.

Correlation to a seed region in bilateral Brodmann area 9.

Functional connectivity MR was averaged from 1,003 typically developing volunteers from the Human Connectome Project dataset. Surface renderings show correlation to a seed region in the left Brodmann area 9 as defined by the WFU PickAtlas toolbox for MATLAB. This image was displayed using BrainNet Viewer software.

Correlation to a seed region in right Brodmann area 46 is shown.

CONNECTIVITY TO BILATERAL DORSOLATERAL PREFRONTAL CORTEX

Functional connectivity MR was averaged from 1,003 typically developing volunteers from the Human Connectome Project dataset. Slices show correlation to a seed region in the bilateral Brodmann area 46 as defined by the WFU PickAtlas toolbox for MATLAB.

BRODMANN AREAS 9 AND 46

Frontal surface-rendered map of areas 9 and 46 is shown, representing Brodmann cortical parcellation scheme for areas 9 and 46 (data source: Connectome Workbench).

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Tags: Imaging Anatomy Brain and Spine

Mar 13, 2021 | Posted by admin in NUCLEAR MEDICINE | Comments Off

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