Non-neoplastic Conditions of the Peritoneum and Neoplastic Conditions of the Mesentery and Omentum




Non-neoplastic Conditions of the Peritoneum


In many of the diseases discussed in this chapter the diagnosis is often initially raised on computed tomography (CT) or magnetic resonance imaging (MRI). However, in most cases, it is not possible to make a categorical diagnosis based on the imaging findings alone and it is necessary to correlate with clinical findings and laboratory tests.


In this section we discuss peritoneal diseases that are not classified as infectious diseases or neoplasms. This diverse group of diseases may be categorized as peritoneal fat-based lesions, peritoneal involvement in multiple-organ disease, and fibrosis-related conditions.


Peritoneal Fat-Based Diseases


Mesenteric Panniculitis


Mesenteric panniculitis is an idiopathic condition with mesenteric fatty infiltration, chronic inflammation (with lymphocytes, macrophages), and fibrosis. Fat necrosis and calcification may occur less commonly. The disease is thought to be a continuum of mesenteric lipodystrophy (where fat necrosis predominates), to mesenteric panniculitis (with chronic inflammation), to retractile mesenteritis (where fibrosis predominates).


Mesenteric panniculitis is twice as common in males than in females. The typical manifestation is one of chronic abdominal pain, fever, and weight loss. Alternatively, the patient may be asymptomatic and the finding is seen incidentally on CT. The CT features of mesenteric panniculitis and retractile mesenteritis are listed in Table 82-1 and shown in Figures 82-1 and 82-2 . The differential diagnosis of these conditions is presented in Table 82-2 .



TABLE 82-1

Computed Tomography Features of Mesenteric Panniculitis and Retractile Mesenteritis



































Computed Tomography Feature Comment
MESENTERIC PANNICULITIS
Increased density of mesenteric fat Root of mesentery most affected
Extension into distal mesentery and retroperitoneum less common
Mesenteric vessels encased by increased density fat No vessel constriction or displacement
Scattered soft tissue mesenteric nodules <10 mm (<5 mm in 80% of cases)
“Fat ring” sign Low-density fat surrounding mesenteric nodules and vessels is seen in >75% of cases; however, not specific and may be seen in mesenteric lymphoma
“Pseudocapsule” sign Thin (<3 mm) capsule seen around expanded misty mesentery in 50% of cases; however, sign not specific and may be seen with liposarcoma
RETRACTILE MESENTERITIS
Mesenteric fibrosis Indrawing and tethering of mesenteric vessels and bowel
Bowel ischemia Seen in severe retractile mesenteritis
Disappearance of “fat ring” and “pseudocapsule” signs When fibrosis becomes more prominent, some features of mesenteric panniculitis disappear



Figure 82-1


Mesenteric panniculitis. Contrast-enhanced axial computed tomography images in a 52-year-old woman with abdominal pain (A) and a 58-year-old man with known lung cancer (B). In both cases, the root of the mesentery is expanded and has a misty appearance (arrowheads). There are small lymph nodes (arrows) with a ring of low-density fat around them (“fat ring” sign). The mesenteric vessels (dashed arrows) have increased density fat around them but are not stenosed.



Figure 82-2


Retractile mesenteritis. A 71-year-old woman presented with nausea and abdominal pain. A, Axial computed tomography (CT) image shows a 5-cm soft tissue mass (arrowhead) in the mesentery with spiculated outline and indrawing and tethering of small bowel loops. B, Axial CT image shows thick-walled small bowel (arrow). The patient underwent laparotomy and was found to have ischemic small bowel, which was resected. The differential diagnosis for the CT finding includes carcinoid tumor and desmoid.


TABLE 82-2

Differential Diagnosis of Mesenteric Panniculitis and Retractile Mesenteritis
























MESENTERIC PANNICULITIS
Liposarcoma Unusual CT findings, such as nodules >10 mm, retroperitoneal extension, displacement of vasculature, mass effect, or invasion of bowel and rapid increase in size of nodules on follow-up imaging, require biopsy.
Lymphoma
Cushing’s syndrome/disease Variation in fat distribution may be caused by corticosteroid excess, with increased volume of mesenteric fat. Nodules are uncommon in Cushing’s disease. Drugs such as lamivudine (Epivir) taken for human immunodeficiency virus infection, may cause increased volume and density of mesenteric fat on CT.
RETRACTILE MESENTERITIS (SPICULATED MESENTERIC MASS)
Carcinoid tumor Biopsy is required if there is no evidence of carcinoid (known tumor, positive on octreotide scan) or tuberculosis (positive cultures).
Desmoid tumor
Mesenteric tuberculosis
Peritoneal mesothelioma

CT, Computed tomography.


In some patients (reports range from 1% to 70%), the presence of mesenteric panniculitis is a sign of malignancy elsewhere. In the absence of malignancy, most patients with mesenteric panniculitis have a favorable prognosis and may be managed conservatively with follow-up CT. Experience of specific treatment is limited. Mesenteric panniculitis involving the mesocolon has been suggested to have a more aggressive course, and surgical treatment is often required. Retractile mesenteritis has a poorer prognosis, mainly owing to bowel ischemia.


Epiploic Appendagitis, Segmental Omental Infarction, and Omental Torsion


Epiploic appendices are pedunculated protuberances of adipose tissue arranged in parallel rows along the antimesenteric border of colon. Each appendage is supplied by one or two small arteries from the colonic vasa recta and drained by a single vein. Given the tenuous vascular supply and narrow neck, these appendages are at risk for ischemia or torsion, resulting in inflammation and infarction.


Epiploic appendagitis is usually primary without an associated bowel pathologic process. Uncommonly, it can be secondary to inflammation of adjacent organs (e.g., resulting in appendicitis, cholecystitis, and diverticulitis).


The typical clinical picture of primary epiploic appendagitis is nonspecific lower abdominal pain that usually subsides within 1 week. The pain may worsen with abdominal stretching or coughing. The CT findings of primary epiploic appendagitis are fairly specific ( Figure 82-3 and Table 82-3 ). Because epiploic appendagitis may be secondary to bowel inflammation, it is important to exclude associated appendicitis and diverticulitis before making the diagnosis of primary epiploic appendagitis. Like epiploic appendagitis, segmental omental infarction belongs to the spectrum of fat-based peritoneal and mesenteric conditions. CT findings are shown in Table 82-3 and Figure 82-4 . Differentiation between epiploic appendagitis and segmental omental infarction is not clinically necessary because conservative therapy with analgesics is all that is required for both conditions. Rarely, laparoscopic surgery may be required in persistently symptomatic segmental omental infarction. Infrequently, segmental omental infarction may be mistaken for a fatty tumor such as liposarcoma. The lack of a well-defined outline and typical site of segmental omental infarction, as well as the clinical presentation, usually help differentiate this entities.




Figure 82-3


Epiploic appendagitis. Axial computed tomography images in a 50-year-old woman undergoing staging for known breast cancer (A) and a 69-year-old man with pelvic pain (B). Epiploic appendagitis appears as a fat density ovoid lesion with peripheral soft tissue rim (arrows). There may be central hyperdensity as a result of a thrombosed epiploic vein ( arrowhead, B ). The lesions are found on the antimesenteric border of the colon, usually anterior or lateral to the colon. The colonic wall is not thickened. Epiploic appendagitis is usually less than 5 cm and does not have mass effect.


TABLE 82-3

Computed Tomography Findings of Epiploic Appendagitis and Segmental Omental Infarction




































Computed Tomography Finding Features or Characteristics Epiploic Appendagitis Segmental Omental Infarction (see Figure 82-4 )
Size 1-5 cm Usually 3-15 cm
Location Immediately adjacent to colon Anterior to transverse colon
Shape Ovoid or clover leaf
Hyperdense rim
Amorphous, no clear outline
Side predominance More common on left More common on right
Mass effect Nil May displace transverse colon posteriorly or parietal peritoneum anteriorly
Central dot sign : Due to thrombosis of central vein or small hemorrhage Seen in 50% Not seen
Follow-up scans Fibrous band or focus of calcification Often dense calcification and/or fibrosis (see Figure, 82-4, B )



Figure 82-4


Segmental omental infarction. A, Axial computed tomography (CT) image in a 26-year-old patient with multiple endocrine neoplasia type I and prior Whipple’s procedure. An area of the omentum (arrowhead) shows a thickened outline and increased central density. Bowel is displaced posteriorly. These are typical features of segmental omental infarction. B, A 65-year-old man presented with metastatic renal cancer requiring regular staging. CT shows an expanded segment of omentum with thin rim (arrows). There is calcification within the omentum (arrowheads) that had been stable for 4 years, indicating chronic omental infarction.


Omental torsion is another cause of acute abdominal pain. It may be idiopathic or secondary to adhesions or tumor. The classic CT sign is a whirling pattern of curvilinear streaks in the omental fat with central hyperdense vascular structure ( Figure 82-5 ). However, the “whirl” sign is not always present, and, if not, differentiation from omental infarction is difficult. It is useful if the diagnosis can be made on CT, because the condition may be treated conservatively.




Figure 82-5


Omental torsion. Axial computed tomography image in a 39-year-old woman with acute right lower quadrant pain. The omentum is swollen (arrowhead) with a central hyperdense structure (dashed arrow) and whirling pattern of curvilinear streaks (solid arrows). The appearance is classic for omental torsion. The patient was managed conservatively.


Peritoneal Involvement in Chronic Multiple-Organ Disease


Amyloidosis


Amyloidosis refers to the extracellular deposition of protein fibrils. Classification of amyloidosis is still evolving. Primary amyloidosis and amyloidosis associated with myeloma show light-chain immunoglobulin deposition (AL type). Amyloidosis associated with chronic dialysis shows immunoglobulin (beta-2 microglobulin) deposition. Amyloidosis secondary to chronic inflammation, such as rheumatoid arthritis, osteomyelitis, and tuberculosis, shows deposition of acute-phase reactant serum amyloid A (AA type). In less common cases of amyloidosis, neuroendocrine peptides such as calcitonin or cytoskeleton proteins such as keratin may be deposited. The CT findings are listed in Table 82-4 .



TABLE 82-4

Computed Tomography Findings in Systemic Diseases That Occasionally Involve the Peritoneum




















































Finding Amyloidosis Whipple’s Disease Mastocytosis Sarcoidosis
Bowel wall or fold thickening Bowel involved in 80% of primary, 60% of secondary disease Seen
Sometimes pneumatosis
Seen in 40%-60% of type 1 disease Very rare. Gastric wall thickening sometimes seen
Lymphadenopathy Occasionally seen Low-density adenopathy * Common in type 3 disease, especially periportal Upper abdominal and retroperitoneal in 40%
Peritoneal thickening Seen Seen Omental thickening Very rare (20 cases reported)
May mimic peritoneal carcinomatosis
Ascites Seen Seen Common in types 2 and 3 Rare; ascites in sarcoid patient more commonly due to cardiac or hepatic disease than to sarcoid
Mesenteric calcification Typically seen Rare Rare Rare
Hepatosplenomegaly (HSM) Seen Not common Often seen 10%-15% have diffuse HSM
Specific computed tomography (CT) findings No specific CT findings Low-density adenopathy, sacroiliitis Diffuse or multifocal hot spots on bone scan; sclerotic or lytic bone lesions on CT Pulmonary involvement in 90%
75% have low-density hepatic lesions and 80% have splenic lesions

* The differential diagnosis for low-density adenopathy includes testicular cancer (nonseminomatous), treated lymphoma, tuberculosis, and cavitary mesenteric lymph node syndrome. Extramedullary hematopoiesis causes low-density masses that simulate adenopathy.



Whipple’s Disease


Although Whipple’s disease has an infectious cause, it is typically classed with other infiltrative diseases because its imaging manifestations may overlap. The causative organism is a gram-positive bacillus, Tropheryma whippelii, which is usually found in soil. CT findings are presented in Table 82-4 and shown in Figure 82-6 .




Figure 82-6


Whipple’s disease in a 62-year-old man with unexplained fever and weight loss. A, Axial computed tomography shows mixed low-density and higher density mesenteric adenopathy (arrowheads). This was initially thought to be due to lymphoma. B, Small bowel follow-through was performed for investigation of concomitant malabsorption. There is evidence of fold and wall thickening (arrowhead) of the small bowel. C, Abdominal radiograph on same patient shows asymmetric sacroiliitis, worse on the left (arrow). Whipple’s disease is a cause of seronegative spondyloarthropathy.


Mycobacterium avium-intracellulare in patients with acquired immunodeficiency syndrome may cause CT findings similar to those of low-density lymphadenopathy and bowel wall thickening. Diagnosis of Whipple’s disease is made by small bowel biopsy and demonstration of lipid-laden macrophages containing bacterial fragments that stain with periodic acid–Schiff.


Systemic Mastocytosis


Mastocytosis is a rare disease characterized by excessive proliferation of mast cells in the skin, bone marrow, and other organs.


The 2001 World Health Organization classification of mastocytosis divides this disease into at least five groups. Some groups are associated with hematologic neoplasms or sarcomas. Imaging of systemic mastocytosis includes a skeletal scintigraphic survey and radiographic and endoscopic gastrointestinal evaluation. Bone scintigraphy appears to correlate well with the progression of bone marrow disease in systemic mastocytosis and may help identify a subgroup of patients with an aggressive clinical course. CT findings are discussed in Table 82-4 and shown in Figure 82-7 .




Figure 82-7


Systemic mastocytosis in a 54-year-old woman with urticaria and weight loss. A, Axial computed tomography shows hepatomegaly (solid arrow), splenomegaly (dashed arrow), moderate-volume adenopathy (arrowhead), and ascites. Change in liver and splenic size is helpful in assessing response to therapy. B, Bone window shows diffuse osteosclerosis (arrows). These features are highly suggestive of systemic mastocytosis, which was proved on bone marrow and skin biopsies.


Sarcoidosis


Sarcoidosis is a multisystem disorder of unknown cause characterized by the accumulation of CD4+ T lymphocytes, mononuclear phagocytes, and noncaseating granulomas. Abdominal CT findings are listed in Table 82-4 and shown in Figure 82-8 .




Figure 82-8


Abdominal sarcoidosis. A, A 43-year-old man presented with known sarcoidosis. Coronal reformatted abdominal computed tomography image shows numerous small low-density lesions in the liver and spleen (arrows), as well as moderate-volume adenopathy (arrowhead). These findings remained stable over 3.5 years of follow-up. They are consistent with sarcoidosis and represent the most common presentation of this disease in the abdomen. B, A 48-year-old woman presented with known sarcoidosis and abdominal cramping. Axial computed tomography shows dense mesenteric soft tissue (arrowhead) enveloping bowel loops, which show thickened folds (arrow). The peritoneal biopsy showed noncaseating granuloma.


Extramedullary Hematopoiesis


Extramedullary hematopoiesis is an ectopic hematopoiesis that occurs as a compensatory response to insufficient bone marrow hematopoiesis. Although any tissue of mesenchymal origin may show extramedullary hematopoiesis, the liver and spleen are the most common sites in the abdomen. Occasionally, the kidneys may be involved. In such cases, CT shows homogeneously and poorly enhancing perinephric masses that appear to engulf the kidneys without architectural distortion, a finding similar to that in renal lymphoma. Serosal and mesenteric implants may occur, possibly as a result of rupture of hepatosplenic nodules. On CT these implants may be mistaken for lymphadenopathy or metastatic disease ( Figure 82-9 ).




Figure 82-9


Extramedullary hematopoiesis in a 16-year-old girl with homozygous sickle cell anemia. Axial computed tomography scan (A) and coronal T2-weighted magnetic resonance image (B) show several peritoneal masses of low density and high signal intensity (solid arrows) around the celiac artery and the hepatic hilum and retroperitoneal masses (arrowheads). These simulate lymphadenopathy. However, in this patient the lesions were foci of extramedullary hematopoiesis. Note the absence of spleen from autosplenectomy and moderately enlarged liver ( dashed arrow, B ).


Eosinophilic Gastroenteritis


Eosinophilic gastroenteritis is an uncommon disorder with eosinophilic infiltration of different layers of the abdominal gastrointestinal tract.


To make the diagnosis of eosinophilic gastroenteritis it is necessary to have gastrointestinal symptoms, eosinophilic infiltration of the gastrointestinal tract (≥20 eosinophils per high power field), lack of eosinophilic infiltration in other organs, and no evidence to support other conditions associated with eosinophilia, such as drug allergy, parasitic infection, or malignancy. The stomach is the most affected organ in eosinophilic gastroenteritis, followed by the duodenum. The small and large bowels are less commonly affected. Eosinophilic gastroenteritis may be classified into mucosal, muscular, and sub­serosal subtypes. The mucosal and submucosal forms are discussed elsewhere. The subserosal type manifests as ascites but cannot be diagnosed on imaging studies. Paracentesis usually shows a sterile exudative effusion containing as many as 95% eosinophils.


Castleman’s Disease


Castleman’s disease (also known as angiofollicular lymph node hyperplasia or giant lymph node hyperplasia) may be unicentric or multicentric. These two subtypes have different biologic behavior and are discussed separately.


Unicentric Castleman’s disease is usually a benign lymphoproliferative disorder of young adults and generally curable with surgical resection. The most common site is the mediastinum. In the abdomen, the retroperitoneum, mesentery, porta hepatis, and pancreas are affected. Peripheral lymphadenopathy is unusual, and laboratory abnormalities are seen in less than 25%. Up to 15% of patients with unicentric Castleman’s disease have the plasma cell histologic type. Approximately half of these patients present with fever and have anemia or an elevated erythrocyte sedimentation rate.


In contrast to unicentric disease, multicentric disease has a poor prognosis. A strong association has been found between multicentric Castleman’s disease and human herpesvirus 8, which is also the etiologic factor of Kaposi’s sarcoma. Most patients with multicentric Castleman’s disease die of fulminant infection or malignancy. Approximately 30% of patients with multicentric disease develop non-Hodgkin’s lymphoma or Kaposi’s sarcoma. There is also a strong association with POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes).


On CT or MRI, well-defined enhancing nodal masses are seen ( Figure 82-10 ). Larger masses (typically >5 cm) may show necrosis. The degree of enhancement may be lower on the plasma cell variant. Adjacent organ invasion is uncommon, except in multicentric Castleman’s disease.




Figure 82-10


Mediastinal Castleman’s disease diagnosed on thoracoscopy in a 67-year-old woman. A and B, Axial computed tomography images of the abdomen and pelvis show enhancing lymph nodes (arrows) in the retroperitoneum and inguinal region. Ascites is also present. The appearances are typical for this disease.


Fibrosis-Associated Conditions


Retractile mesenteritis (see earlier), mesenteric fibromatosis (desmoid tumor), and inflammatory pseudotumor are linked by the presence of fibroblasts or fibrosis in the mesentery. However, they are distinct in cause and biologic behavior.


Mesenteric Fibromatosis (Abdominal Desmoid)


Mesenteric fibromatosis is a locally aggressive fibroproliferative process that has the capacity to infiltrate or recur but is considered benign because it does not metastasize.


Desmoid tumors have a predilection for surgical sites (e.g., the mesentery or abdominal wall after colectomy or at the site of ilioanal pouch anastomosis). Sporadic abdominal desmoids are associated with somatic mutations of the beta-catenin gene. In patients with familial adenomatosis coli there is an inactivating germline mutation in the adenomatous polyposis coli gene. Both gene mutations result in increased transcription of beta-catenin protein, which causes cellular adherence and explains the biology of desmoid tumors.


The CT and MRI findings of desmoids are nonspecific. The contour is smooth in approximately two thirds of cases. Spiculated lesions may mimic carcinoid tumors ( Figure 82-11 ). The lesions are usually of low signal intensity on T1-weighted precontrast sequences and show variable signal on T2-weighted sequences. The enhancement pattern is variable from none to mild homogeneous or heterogeneous enhancement. Previous CT and MRI reports have indicated that strong enhancement is unusual and that most tumors enhance to the same degree as skeletal muscle. However, a recent MRI study indicates that strong enhancement is often seen. Necrosis is uncommon.


Jan 22, 2019 | Posted by in GASTROINTESTINAL IMAGING | Comments Off on Non-neoplastic Conditions of the Peritoneum and Neoplastic Conditions of the Mesentery and Omentum
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