Ocular and Orbital Tumors: Viewpoint-Fractionated Radiation


Author

Year

Reference

n

Technique

Total dose (Gy)

Dose per fraction (Gy)

Visual outcome

Tumor outcome

Re-progression (%)

Radiation-induced toxicities

Improved (%)

Stable (%)

Worse (%)

Control (%)

Progression (%)

Acute (%)

Late (%)

Smith et al.

1981

[12]

5

2DRT

53

2

80

20

0

100

0

0

None

Dry eye (20 %)

Cataract (20 %)

Kupersmith et al.

1987

[13]

4

2DRT

55

1.8

75

25

0

100

0

0

NR

NR

Sarkies et al.

1987

[14]

4

2DRT

40

3.3

0

50

50

100

0

0

NR

NR

Kennerdell et al.

1988

[7]

6

2DRT

55

1.8

100

0

0

100

0

0

None

None

Becker et al.a

2002

[4]

42

FSRT

54

1.8

31

67

2

100

0

0

Erythema (25 %)

None

Alopecia (100 %)

Turbin et al.

2002

[15]

18

3DCRT

40–55

1.4–1.8

44

NR

NR

100

0

0

NR

NR

Andrews t al.

2002

[16]

33

FSRT

51

1.8

42

50

8

100

0

0

NR

Optic neuritis (3 %)

Pitz et al.a

2002

[17]

16

FSRT

54

1.9

40

60

0

100

0

0

Erythema (30 %)

Pituitary disorder (7 %)

Alopecia (68 %)

Liu et al.

2002

[18]

5

FSRT

45–54

1.8

80

20

0

100

0

0

None

None

Saeed et al.

2003

[19]

6

FSRT

14

14

83

0

17

100

0

0

NR

NR

Narayan et al.

2003

[20]

14

3DCRT

45–54

1.8–2.0

36

50

14

100

0

0

Eye pain (7 %)

Dry eye (7 %)

Retinopathy (7 %)

Baumert et al.

2004

[21]

23

FSRT

43–45

1.8–2.0

70

22

8

100

0

0

Eye pain (4 %)

Retinopathy (7 %)

Richards et al.

2005

[22]

4

FSRT

50–54

1.7

100

0

0

100

0

0

NR

NR

Landert et al.

2005

[23]

7

FSRT

52–59

1.7–1.8

86

0

14

100

0

0

NR

NR

Sitathanee et al.

2006

[24]

12

FSRT

45

1.8

33

58

9

100

0

0

None

None

Litré et al.

2007

[25]

8

FSRT

50

1.8

100

0

0

100

0

0

None

Vitreous hemorrhage (13 %)

Arvold et al.

2009

[10]

22

FSRT

50–58

1.8

63

32

5

100

0

1

None

Retinopathy (14 %)

Milker-Zabel et al.

2009

[26]

32

FSRT

50

1.8

38

59

3

100

0

0

NR

Optic neuritis (3 %)

Smee et al.

2009

[27]

12

3DCRT

50–54

1.8–2.0

92

0

8

100

0

0

None

None

Saeed et al.

2010

[6]

34

3DCRT/FSRT

45–54

1.8

41

50

9

100

0

0

Erythema (47 %)

Dry eye (15 %)

Alopecia (10 %)

Cataract (9 %)
 
Retinopathy (9 %)

Lesser et al.

2010

[6]

11

3DCRT

54

1.8

91
 
9

100

0

0

NR

NR

Liu et al.

2010

[28]

30

SRS

10–17

NR

36

44

20

100

0

0

None

None

Kurt et al.

2010

[29]

2

SRS

10–17

3.5–6.5

100

0

0

100

0

0

None

None

Metellus et al.

2011

[30]

9

3DCRT

58

1.8

78

22

0

100

0

0

NR

NR

Abouaf et al.

2011

[3]

10

2DRT/

3DCRT/

54

1.8–2.0

60

10

30

100

0

0

Conjunctivitis (10 %)

Dry eye (20 %)

FSRT/IMRT

Alopecia (10 %)

Cataract (40 %)
  
Retinopathy (20 %)

Adeberg et al.

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Jun 2, 2017 | Posted by in GENERAL RADIOLOGY | Comments Off on Ocular and Orbital Tumors: Viewpoint-Fractionated Radiation

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