Superior Prefrontal Cortex (Area 8)

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Superior Prefrontal Cortex (Area 8)

Main Text

Location and Boundaries

Location

• Caudal portion of middle frontal gyrus
• Caudal portion of both medial and lateral superior frontal gyrus

Boundaries

• Medial: Cingulate sulcus
• Lateral: Inferior frontal sulcus
• Rostral: Middle of superior and middle frontal gyri
• Caudal: Caudal end of superior and middle frontal gyri
• Surrounded by anterior cingulate cortex (area 32), premotor cortex (area 6), presupplementary motor area (area 6), and dorsolateral prefrontal cortex (area 9)

Function

Theory of Mind

• Mentalizing or inferring mental states of others

Simulating Future Events

• Predicting behavior of others by creating model based on personality traits
• Imaging and planning future events

Self-Referential Processes

• Autobiographical memory (i.e., recalling past personal experience)
• Internal dialogue

Structural Connections

Cortical

• Premotor cortex (area 6)
• Dorsolateral prefrontal cortex (areas 9, 46)
• Inferior frontal gyrus (areas 44, 45, and 47)
• Anterior cingulate cortex (area 32)
• Frontal pole (area 10)
• Retrosplenial cingulate cortex (area 30)
• Posterior cingulate cortex (areas 23, 31)
• Parahippocampal gyrus (areas 28, 34, 35, and 36)
• Superior temporal gyrus and sulcus (area 22)
• Inferior parietal lobule (areas 39, 40)
• Insula (area 13)

Subcortical

• Mediodorsal nucleus of thalamus

Functional Connections

Coactive Regions

• Frontal pole (area 10)
• Anterior cingulate cortex (areas 24, 32, and 33)
• Dorsolateral prefrontal cortex (areas 9, 46)
• Posterior cingulate cortex (areas 23, 31)
• Precuneus (area 5)
• Inferior parietal lobule (areas 39, 40)
• Middle temporal gyrus (area 21)
• Inferior frontal gyrus (areas 44, 45, and 47)

Associated Literature Keywords (NeuroSynth)

• Default, colors, resting state, reactivity, money, dyslexia, vision, subsequent, autobiographical, past, associative

Area 8-Associated Disorders

Alzheimer Disease

• Amyloid-β deposits in regions of default mode network, including superior prefrontal cortex

Autism

• Characterized by difficulty empathizing and inferring others’ mental states

Major Depressive Disorder

• Characterized by rumination and focusing on self

Image Gallery

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SUPERIOR PREFRONTAL CORTEX: LOCATION AND COACTIVATION

Axial and sagittal sections of superior prefrontal cortex map are shown, representing the Brodmann cortical parcellation scheme for area 8 (data source: WFU PickAtlas).

Coactivation map of Brodmann area 8 shows brain regions that reliably activate with the centroid of voxels lying within area 8 in over 4,000 studies from the NeuroSynth database. Image is the average of left and right coactivation maps.

CONNECTIVITY TO SUPERIOR PREFRONTAL CORTEX

Functional connectivity MR was averaged from 1,003 typically developing volunteers from the Human Connectome Project dataset. Surface renderings show correlation to a seed region in the left Brodmann area 8 as defined by the WFU PickAtlas toolbox for MATLAB. This image was displayed using BrainNet Viewer software.

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Tags: Imaging Anatomy Brain and Spine

Mar 13, 2021 | Posted by admin in NUCLEAR MEDICINE | Comments Off

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