2 Focal Nodular Hyperplasia

CASE 2


Clinical Presentation


A 42-year-old woman presents with upper right quadrant tenderness and hepatomegaly.




image

Fig. 2.1 Abdominal contrast-enhanced CT scan shows an ill-defined, homogeneously enhancing lesion within the caudate lobe of the liver (arrow) with a hypodense central scar (dashed arrow).


Radiologic Findings


Abdominal computed tomography (CT) scan (Fig. 2.1) reveals a poorly defined lesion within the caudate lobe with a low-density central scar. Abdominal magnetic resonance imaging (MRI) (Fig. 2.2) was subsequently performed. The liver mass appears isointense to normal liver parenchyma on T2- and T1-weighted images with a central scar that is T2 hyperintense. Arterial enhancement is noticed within the lesion as well as delayed enhancement of the scar.


Diagnosis


Focal nodular hyperplasia (FNH)


Differential Diagnosis



  • Fibrolamellar hepatocellular carcinoma
  • Hepatocellular carcinoma (HCC)
  • Hypervascular liver metastasis
  • Adenoma
  • Hemangioma

Discussion


Background


FNH is the second most common hepatic benign tumor after hemangioma and is found in 1% of the population (mainly middle-aged women). It is most frequently seen as a solitary lesion even though multiple masses have been described in 20% of patients. Histologically, FNH is characterized by the presence of normal hepatocytes with a malformed biliary draining system. Prompt diagnosis is mandatory to distinguish this lesion from malignant hepatic masses such as fibrolamellar carcinoma, HCC, cholangiocarcinoma, and hypervascular metastasis.

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Dec 26, 2015 | Posted by in GASTROINTESTINAL IMAGING | Comments Off on 2 Focal Nodular Hyperplasia

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