3 Mediastinum and Thymus



Cameron Hassani and Farhood Saremi

3 Mediastinum and Thymus



Introduction


The mediastinum (Latin, media = middle and stare = to stand; i.e., that which stands in the middle) is a compartment within the thorax which contains all the thoracic organs, apart from the lungs and pleura. It is bounded superiorly by the thoracic inlet and inferiorly by the diaphragm. The sternum and ribs form the anterior-most margin of the mediastinum and the vertebral column forms the posterior margin. Laterally, it is bounded by the mediastinal pleura on both sides. The mediastinum is a complex area containing structures vital to life, both large and small, such as the heart, major vessels, trachea, esophagus, nerves, and lymph nodes. Fat also makes up a large component of the mediastinum. In this chapter, the anatomy of above structures will be reviewed. Azygous system, systemic veins, aorta, and pulmonary arteries are discussed in related chapters.



Compartmentalized Anatomy


It is useful to divide the mediastinum into compartments for the purposes of forming a differential diagnosis when dealing with masses in the mediastinum. However, the mediastinum lacks true anatomical boundaries to serve as a basis for compartmentalized anatomy. As a result, several differing models have been developed in attempts to compartmentalize the mediastinum. 1 ,​ 2 Each model is different from the next, and some are based on plain chest radiography. As may be expected, there is discordance between the different models.


Traditionally and historically, radiologists have mostly used systems which divided the mediastinum into anterior, middle, posterior, and sometimes superior mediastinal compartments, based on chest radiograph. More recently formalized systems based on cross-sectional computed tomography (CT) imaging and expert consensus have been proposed. Initially a four-compartment model (anterior, middle, posterior, and superior mediastinum) by the Japanese Association for Research of the Thymus (JART) and then a three-compartment model by the International Thymic Malignancy Interest Group (ITMIG) have been introduced. 3 It should be emphasized; these models and all the various historical models are based on expert opinion and preferences, as there are no real anatomical planes to separate the “anterior,” “middle,” and “posterior” mediastinum. These compartments exist to optimize the clinician’s ability to identify and distinguish pathology based on location. 4 ,​ 5 We will further discuss the ITMIG classification schema which will likely become the most widely accepted system.



ITMIG Classification


The ITMIG adopted the following system for compartmentalization of the mediastinum (Fig. 3‑1 , Fig. 3‑2 , Fig. 3‑3). ITMIG divides the mediastinum into three compartments: (a) prevascular (anterior mediastinum), (b) visceral (middle mediastinum), and (c) paravertebral (posterior mediastinum) compartments (Table 3‑1).

Fig. 3.1 Mediastinal compartments: blue—prevascular (anterior mediastinum), orange—visceral (middle mediastinum), and green—paravertebral (posterior mediastinum) compartments.
Fig. 3.2 Sequential axial images of the thorax demonstrating the boundaries and compartments of the ITMIG mediastinal classification system. Blue—prevascular (anterior mediastinum), orange—visceral (middle mediastinum), and green—paravertebral (posterior mediastinum) compartments. Visceral–paravertebral compartment boundary is shown by dashed blue line and the pericardium margin is shown by orange line.
Fig. 3.3 Sagittal image of the thorax demonstrating the boundaries and compartments of the ITMIG mediastinal classification system.














































Table 3.1 Mediastinal compartment’s (ITMIG) CT-based classification

Name


Boundaries


Contents


Prevascular (anterior) compartment


Superior: Thoracic inlet


Thymus, lymph nodes, brachiocephalic vein, and fat


Inferior: Diaphragm


Anterior: Anterior aspect of pericardium


Lateral: Mediastinal pleura


Visceral (middle) compartment


Superior: Thoracic inlet


Pericardium, heart, superior vena cava, ascending thoracic aorta, aortic arch, arch vessels, descending thoracic aorta, proximal (intrapericardial) pulmonary arteries, thoracic duct, trachea/carina, esophagus , lymph nodes , vagus nerves, and phrenic nerves


Inferior: Diaphragm


Anterior: Anterior aspect of pericardium


Posterior: Visceral–paravertebral compartment boundary line


Lateral: Mediastinal pleura


Paravertebral (posterior) compartment


Superior: Thoracic inlet


Thoracic spine and paravertebral soft tissues, fat, autonomic nervous plexus


Inferior: Diaphragm


Anterior: Visceral–paravertebral compartment boundary line


Posterior: Vertical line along the posterior margin of the chest wall and the lateral margin of vertebral transverses processes


Lateral: Mediastinal pleura


The prevascular compartment (anterior mediastinum) is bounded by the thoracic inlet superiorly, the diaphragm inferiorly, the sternum anteriorly, the anterior aspect of the pericardium posteriorly, and the mediastinal pleura laterally. The major components of this compartment are the thymus, lymph nodes, left brachiocephalic vein, and fat. The prevascular compartment extends from the thoracic inlet to the diaphragm, always anterior to the heart and pericardium. Displacement of these structures posteriorly is a useful tool to localizing any mass of questionable origin to the prevascular compartment. Common pathologies include thymic lesions, teratoma, lymph node diseases, and hematoma. The prevascular compartment is a common location for collection of hematoma after trauma or surgery.


The visceral compartment (middle mediastinum) is bounded by the thoracic inlet superiorly, the diaphragm inferiorly, and the anterior pericardium anteriorly. The posterior margin is defined by a line connecting points on each vertebral body 1 cm posterior to the anterior cortex of the vertebral bodies, the so-called “visceral–paravertebral compartment boundary line.” The major components of this compartment are the pericardium, heart, superior vena cava, ascending thoracic aorta, aortic arch, descending thoracic aorta, proximal (intrapericardial) pulmonary arteries, thoracic duct, trachea/carina, esophagus, nerves, and lymph nodes. 6 ,​ 7


The paravertebral compartment (posterior mediastinum) is bounded by the thoracic inlet superiorly, the diaphragm inferiorly, the visceral compartment anteriorly (“visceral–paravertebral compartment boundary line” which is defined in the preceding paragraph) and a vertical line along the posterior margin of the chest wall and the lateral margin of vertebral transverse processes posteriorly. The major structures of this compartment are the thoracic spine, paravertebral soft tissues/fat, and autonomic nervous plexus. Enlarged lymph nodes can be found anywhere in the mediastinum. Common focal pathologies include nerve/nerve sheath masses (i.e., neurofibroma, schwannoma) and tumors of the sympathetic chain such as paraganglionic cell neoplasms. Other uncommon pathologies extramedullary hematopoiesis (i.e., thalassemia), neurenteric cysts, and rarely meningoceles.



Components



Ligaments


The contents of the mediastinum are suspended/anchored to the chest wall or connected one another via a series of ligaments. While many of them are quite small, several of these ligamentous connections are large enough to be appreciated by CT or magnetic resonance imaging (MRI).



Inferior Pulmonary Ligament

The inferior pulmonary ligament (IPL) is a double layer of pleura which becomes continuous with intervening connective tissue to form a contiguous ligament (Fig. 3‑4) (see Chapter 4, Pleura). Specifically, at the level of the pulmonary hilum both the anterior and posterior pleura come together and encase the hilum. Just below the pulmonary vein, artery, and bronchus the two pleura (along with intervening veins and lymphatics) fuse together to form the IPL. 8 ,​ 9 The IPL, which takes a triangular shape at the hilar level, travels caudally along the mediastinal pleural surface to either terminate at the diaphragmatic pleura or end as a free edge. At axial CT, it is most commonly seen as a well-defined linear opacity extending horizontally from the paravertebral (posterior) mediastinal pleural surface. 10 It is best seen at the level of the diaphragm, where a slight widening of its base (in order to contact the diaphragm) makes it more apparent (Fig. 3‑5 , Fig. 3‑6).

Fig. 3.4 Medial surface of the left lung demonstrating the inferior pulmonary ligament (arrows) in relation to the pulmonary hilum.
Fig. 3.5 Transverse cadaveric and CT images of the thorax at the level of the lower heart demonstrating the left inferior pulmonary ligament (arrows).
Fig. 3.6 Transverse and sagittal CT images of the thorax demonstrating the left inferior pulmonary ligament (arrows).

While the IPL is an extraparenchymal structure, yet it can be surrounded by lung parenchyma especially in emphysematous lungs, giving it the appearance of intraparenchymal subsegmental atelectasis or scarring. The IPL has clinical significance for lung cancer staging, as lymphadenopathy in the IPL is considered a station 9 lymph node. IPL functions to anchor the lower lobe to both the mediastinum and the diaphragm. In patients with disruption of the IPL, there is a reported increased incidence of lung torsion, thought to be due to increased mobility of the lower lobe. IPL may be injured in trauma, and posttraumatic pneumatocele especially in children can be observed at this anatomical area.



Ligamentum Arteriosum

Ligamentum arteriosum (LA) is a small ligament which is a remnant of the fetal ductus arteriosus. The LA is seen as a calcified structure in nearly 50% of adults near the aortic arch passing into the aortic–pulmonary window. 11 A calcified LA is considered an insignificant normal finding; however, it is many times mistaken for aortic atherosclerotic disease 12 (Fig. 3‑7). The calcification may be a single focus in the setting of a noncalcified tubular structure, a linear or curvilinear calcification, or large clumped calcifications. The LA is a notable piece of anatomy as it is theorized that a fixed tethering of the aorta by this ligament accounts for a large proportion of aortic injuries in the area of the LA. It should be remembered that the LA serves as an important landmark/border when distinguishing aortopulmonary (AP) window (station 5) lymph nodes from left paratracheal (station 4L) lymph nodes, the former being to the left of the LA.

Fig. 3.7 (a) Transverse and (b) sagittal CT images of the thorax demonstrating a non-calcified ligamentum arteriosum (arrows) which can be very thin, small, and easily missed when not calcified. (c) Transverse, and (d) sagittal CT images of the thorax demonstrating a calcified ligamentum arteriosum (arrows). This ligament extends between the descending arch of the aorta (DA) and left pulmonary artery (PA).


Sternopericardial Ligaments

There are both superior and inferior sternopericardial ligaments (SPLs) which attach the fibrous pericardium to the posterior surface of the sternum. The superior SPL attaches the pericardium to the manubrium, while the inferior SPL attaches to the xiphoid process (Fig. 3‑8).

Fig. 3.8 Sternopericardial ligament: (a) axial and (b) sagittal CT. The sternopericardial ligament (arrows) attaches the fibrous pericardium to the posterior surface of the sternum, best seen on sagittal projection (b).


Pericardiophrenic or Phrenopericardial Ligament

The pericardiophrenic ligament (PPL) is a triangular structure which is formed by the combination of pleural reflection, right phrenic nerve, and pericardiophrenic bundle vessels. At CT, it has a very similar appearance to the IPL, however, the PPL has a characteristic position either lateral or anterior to the inferior vena cava (IVC) (Fig. 3‑9). Sometimes, the phrenic nerve and/or pericardiophrenic bundle can be seen as distinct structures entering the PC.

Fig. 3.9 (a) Pericardial ligaments. The pericardiophrenic ligament (PPL) is a triangular structure which is formed by the combination of pleural reflection, right phrenic nerve, and pericardiophrenic bundle vessels. (b) Anatomical course of the right phrenic artery is shown. (c) The PPL (red arrows) is a linear structure which is usually seen projecting at the level of the inferior vena cava (IVC) or anterior to the IVC (blue arrow) while the inferior pulmonary ligament is usually more posteriorly located (not shown). D, diaphragm; RA, right atrium; RSPV, right superior pulmonary vein; SVC, superior vena cava.


Thyrothymic Ligament

The thyrothymic ligament connects the thyroid to the upper parts of the thymus on either side of the neck and mediastinum (Fig. 3‑10). The inferior extents of these ligaments pass into the mediastinum as they connect to the thymus. They serve as an important anatomical landmark during neck dissection when searching for the parathyroid glands. In cases of mediastinal parathyroid adenoma, many times the adenoma is located along this ligament.

Fig. 3.10 Drawing of the normal thyroid, thymus, and the thyrothymic ligament. The thyrothymic ligament maintains connection between the two glands across the thoracic inlet.


Thymus


The thymus is relatively centrally located in the prevascular compartment of the mediastinum (Fig. 3‑10 , Fig. 3‑11). It resides between the sternum anteriorly and the pericardium, aortic arch, and left brachiocephalic vein posteriorly. 13 ,​ 14 Laterally the thymus is bordered by the mediastinal pleural surfaces.


While this is the classic normal location of the thymus, it can also be located ectopically in the neck. This is in part the result of thymic development, in which the normal thymus descends from the third and possibly fourth pharyngeal pouches down the neck and into the mediastinum. Any arrest of this pathway will result in ectopic thymic tissue. In 20 to 25% of people, separate islands of residual thymic tissue can be found in the neck, mediastinum, and lung as a result of the thymic development process.


The thymus grows during fetal development, through birth into puberty where it achieves its largest relative size (Fig. 3‑12). After puberty, a process of involution begins and the thymus diminishes in size as age increases 15 ,​ 16 (Fig. 3‑12). This normal involution is known to accelerate with exogenous steroid use. The thymus has a prime role in the peripheral immune system, and the age-related normal involution is thought to be related to weaker overall immune systems in the elderly. Why this occurs remains a mystery. 17


The thymus is comprised of two distinct lobes which are connected centrally by loose connective tissue or an intermediate lobe (Fig. 3‑12 , Fig. 3‑13). A capsule made of collagenous fibers encases both of these lobes. Capsular septa separate the lobes into smaller cortical lobules, with the deeper medullary space remaining as one continuous structure. 18 ,​ 19 These lobules and lobes can be appreciated on CT scans readily as a normal finding which distinguishes the thymus from normal and abnormal adjacent structures.


The thymus may also become hyperplastic in patients. When the body is under stress, the thymus may actually shrink with a rebound enlargement after removal of stress. This phenomenon is most common in pediatric and adolescent patients after periods of stress (burns, surgery, infection, steroids) but is also known to happen commonly in adults after chemotherapy or radiotherapy and has also been reported with steroid use, after surgery, and with infection (Fig. 3‑13). Common pathologies of the thymus include thymic cyst and thymoma (Fig. 3‑13). Thymoma usually presents as a well-defined mass in the prevascular mediastinum. It should be differentiated from other common pathologies in this region such as teratoma or lymphoma. Myasthenia gravis is a distinct clinical presentation of the thymoma and thymic hyperplasia.


The thymus maintains several connections to adjacent structures via ligaments and direct connections to maintain a relatively suspended position in the prevascular space of the mediastinum. 19 Superiorly, a thyrothymic ligament connects directly to the inferior thyroid (Fig. 3‑10). Posteriorly, a layer of fascia maintains a connection to the brachiocephalic veins and aorta/great vessels. Inferiorly, connective tissue maintains a connection with the pericardium, a connection which persists from early development.


When discussing thymic arterial or venous anatomy, it is always important to remember that considerable variation exists. 20 ,​ 21 Thymic arterial blood supply arrives via the superior, lateral, and posterior thymic arteries. The ultimate origin of these arteries is variable; arising from the inferior thyroid artery, internal thoracic artery, pericardiophrenic artery, or anterior intercostal arteries. The superior thymic artery usually arises from the inferior thyroidal artery or middle thyroid artery. The lateral thymic arteries are usually branches of the right and sometimes left internal thoracic artery. When present, the posterior thymic arteries are direct branches of the brachiocephalic artery and aorta. Venous drainage is accomplished by a venous plexus predominating on the posterior side of the thymus (Fig. 3‑14). This plexus is drained by two small veins on the posterior side of each thymic lobe. Finally, these smaller veins join to form a larger single thymic vein (sometimes referred to as the great vein of Keynes). 20 This thymic vein ultimately drains into the left brachiocephalic vein. Variant anatomy exists where separate thymic veins drain into the left inferior thyroidal vein, internal thoracic vein, or superior vena cava.

Fig. 3.11 Large thymus in a pediatric patient. Anteroposterior and lateral chest X-rays showing bilobed appearance of the thymus.
Fig. 3.12 Serial images of the thymus (arrows) demonstrate normal involution as age increases in a (a) 14-year-old, (b) an 18-year old, (c) a 24-year old patient. Note the normal bilobed appearance of the thymus in (a) and triangular shape which conforms to the mediastinum in (b). Intercalated fat within the thymus increases with age. With close attention, the intermediate lobe of the thymus (arrow in c) can be seen as a distinct structure which maintains a connection between the left and right lobes. In certain patients, thymic rebound is also observed, for example (d) an adult female undergoing chemotherapy. Notice the thymus maintains a bilobed appearance in (d).
Fig. 3.13 (a,b) Axial CT images showing ectopic thymic tissue in the right paratracheal region medial to the superior vena cava in a 22-year-old patient with normal thymus. Ectopic thymus in usually seen in aortopulmonary window in 20% and aortocaval groove in 12% of cases. (c) Axial and (d) coronal CT showing thymic hyperplasia in a 36-year-old man. The two lobes of the thyroid are nicely shown. (e) Thymoma; (f) teratoma. Teratoma usually contains different mesenchymal elements such as fat and calcification that makes diagnosis easy. Myasthenia gravis is a distinct clinical presentation of the thymoma and thymic hyperplasia.
Fig. 3.14 Thymic veins are shown in two different cases. (a–c) Axial, sagittal, and coronal CT images. Thymic venous drainage is variable, but a common pattern is of several small veins draining to a dominant great vein of Keynes (blue arrow) which then will drain into the left brachiocephalic vein (LBCV) as it crosses the mediastinum. (b, c) The great vein of Keynes can be quite tortuous. (d–f) Same projections in a different patient showing more extensive venous channels in the anterior mediastinum with the majority draining into the brachiocephalic vein or superior vena cava.


Mediastinal Fat


Mediastinal (pericardial) fat is generally unencapsulated fat which encases the various mediastinal structures without compression or displacement, a characteristic trait of benign mediastinal fat. It should not be confused with the epicardial (subepicardial) fat which is located between the visceral layer of the pericardium and the myocardium (Fig. 3‑15). 22 ,​ 23 Mediastinal fat predominates in the prevascular compartment (i.e., anterior mediastinum). The epicardial adipose tissue is supplied by branches of the coronary arteries, whereas the mediastinal fat is supplied from different sources including the superior pericardial, middle pericardial, and pericardiophrenic arteries, branches of the internal mammary artery. 23 When the amount of fat is abnormally increased, it is usually referred to as mediastinal lipomatosis which is commonly due to obesity, diabetes, and exogenous steroid use (Fig. 3‑16). Excess fat in the mediastinum can influence patency of the vessels. 24

Fig. 3.15 Mediastinal fat: (a) Three-dimensional CT color mapping showing the mediastinal fat in orange color. (b) Axial image of the heart at the level of the coronary sinus (CS) shows different compartments of the intrathoracic fat including the mediastinal (red stars) fat and the epicardial fat (yellow stars). The pericardial sac is shown as a thin line between the two compartments. The mediastinal fat is located outside the pericardium and the epicardial fat is located between the pericardial sac and the myocardium. The coronary vessels and the coronary sinus are embedded in the epicardial fat. CS, coronary sinus; IVC, inferior vena cava; RV, right ventricle.
Fig. 3.16 (a) Mediastinal lipomatosis compressing vessels. (b) Axial image; fatty infiltration around the superior vena cava (SVC) can cause obstruction and difficulty in passing catheters. (b) Axial image of the heart showing stenosis of the coronary sinus due to excess fat accumulation AA, ascending aorta; LA, left atrium.


Lymph Nodes


Thoracic mediastinal lymph nodes serve to filter lymph through a series of lymphatic vessels. Lymph nodes play a vital role in filtering infections and debris before entering the bloodstream, but they also act as a conduit to collect malignant cells. In this regard, they serve as an important prognosticator when evaluating lung and other types of cancers.


The pattern of mediastinal lymphadenopathy has become an integral part of lung cancer staging. Chief among the staging systems is the clinical TNM (cTNM) staging system which is typically used before any treatment regimen for lung cancer is begun. This system attempts to reliably stage a patient’s cancer based on the extent of disease with local, regional, or distant lymph node involvement as a key determinant of disease stage. Several standardized nomenclature systems have been developed; however, the one adopted by the International Association for the Study of Lung Cancer (IASLC) appears to be the most widely used 25 (Fig. 3‑17 , Fig. 3‑18 , Fig. 3‑19). Lymph node stations of the mediastinum are classified in Table 3‑2.


















































































































Table 3.2 Mediastinal lymph node stations

Name


Station


Borders


Right upper paratracheal


2R


Superior: Apex of the right lung/pleural space and the upper border of manubrium


Inferior: Intersection of left innominate vein with trachea


Left: Left border or trachea


Right: Mediastinal pleura


Left upper paratracheal


2L


Superior: Apex of the right lung/pleural space and upper border of manubrium


Inferior: Superior margin of aortic arch


Left: Mediastinal pleura


Right: Left lateral border of trachea


Prevascular


3A


Superior: Upper border of manubrium


Inferior: Carina


Anterior: Posterior aspect of sternum


Posterior: Anterior border of SVC, great vessels, and pericardium


Left: Left pleura


Right: Right pleura


Retrotracheal


3P


Superior: Apex of chest


Inferior: Carina


Anterior: Posterior aspect of trachea


Right lower paratracheal


4R


Superior: Intersection of left innominate vein with trachea


Inferior: Lower border of azygous vein


Left: Left lateral border of trachea


Left lower paratracheal


4L


Superior: Superior border of the aortic arch


Inferior: Upper border of the main pulmonary artery


Left: Ligamentum arteriosum


Right: Left lateral border of trachea


Subaortic (AP windows)


5


Superior: Lower border of aortic arch


Inferior: Upper border of left main pulmonary artery


Right: Ligamentum arteriosum


Para-aortic


6


Superior: Line tangential to the upper border of the aortic arch


Inferior: Lower border of the aortic arch


Anterior: Imaginary horizontal line from the anterior wall of aortic arch


Subcarinal


7


Superior: Carina of the trachea


Inferior: Upper border of the lower lobe bronchus and lower border of the bronchus intermedius


Left: Medial margin of the main bronchus


Right: Medial margin of the right main bronchus and bronchus intermedius


Paraesophageal


8


Superior: Upper border of the left lower lobe bronchus and lower border of the bronchus intermedius


Inferior: Diaphragm


Inferior pulmonary ligament


9


Superior: Inferior pulmonary vein


Inferior: Diaphragm


Abbreviation: SVC, superior vena cava.


However, care must be taken when localizing lymph nodes, as not all the mediastinal lymph nodes are classified under the IASLC lymph node map. Lymph node groups that have not been explicitly classified include diaphragmatic lymph nodes, which appear around the diaphragm; some authors may consider these to be prevascular lymph nodes as they are anterior to the pericardium (see Chapter 10, Diaphragm) (Fig. 3‑20). Intercostal lymph nodes and internal mammary artery lymph nodes are very close and appear contiguous with the mediastinum but would be considered chest wall structures. 26


Mediastinal lymph nodes primarily drain lymph from the lungs and pulmonary hila in certain patterns. While we will review some of the most common pathways for lymph node drainage, it should be noted that considerable variability exists between many of studies done to date on this topic. 27 ,​ 28


With that said, the right upper lobe tends to drain to the right paratracheal station (level 4R) and prevascular (level 3A) lymph nodes, both of which are above the level of the heart (Fig. 3‑20). For example, isolated subcarinal lymphadenopathy is much less common in right upper lobe cancers. From the 4R level, lymph tends to drain into the high right paratracheal (2R) and then scalene/supraclavicular lymph nodes. The right middle lobe, however, most frequently drains to the subcarinal station (level 7) followed by the lower right paratracheal station (level 4R). The right lower lobe is most commonly seen draining to the subcarinal (level 7) and paraesophageal (level 8) stations. 29


The left upper lobe malignancies seem to drain to the subaortic and para-aortic lymph nodes (level 5 and 6) and left low paratracheal (4L). Note should be made that the lingula actually drains to the subcarinal lymph nodes first, then to the subaortic and para-aortic stations.


Finally, the left lower lobe tends to drain to the subcarinal station 7 followed by subaortic, 5 left paratracheal (4L), paraesophageal, 8 and inferior pulmonary ligament 9 lymph nodes. The left lower lobe is notable as it tends to drain to contralateral mediastinal lymph nodes more frequently than any other lobe (Fig. 3‑20).

Fig. 3.17 IASLC lymph node map. (Adapted from El-Sherief et al 2014. 25 )
Fig. 3.18 (a–d) Lymph node station based on International Association for the Study of Lung Cancer (IASLC) classification. Border of 4L and 4R is the left wall of the trachea. Lateral margins of both the subcarinal and paraesophageal stations are the medial walls of the bronchi. The inferior-most extent of level 7 is the lower border of the bronchus intermedius on the right and left lower lobe bronchus on the left, after which level 8 arises. When the right middle lobe (RML) bronchus (*) or the left lower lobe bronchus is seen, then you are looking at level 8. Level 9 lymph nodes are located at the inferior pulmonary ligament on either side, spanning from the inferior pulmonary vein to the diaphragm. Ao, aortic arch; LBCV, left brachiocephalic vein; LSCA, left subclavian artery; LPA, left pulmonary artery; SVC, superior vena cava.
(e-g)
Fig. 3.19 Mediastinal lymph nodes that do not fall into the current IASLC map, anterior and midline diaphragmatic lymph nodes.
Fig. 3.20 (a–c) Common patterns of lymph drainage from the lung lobes.

The mediastinal lymph nodes receive vessels from the lungs, thymus, thyroid, esophagus, diaphragm, liver, pericardium, and heart.

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Mar 16, 2021 | Posted by in CARDIOVASCULAR IMAGING | Comments Off on 3 Mediastinum and Thymus
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