Clinical Presentation
A 55-year-old woman presents with abdominal pain, low-grade fever, and weight loss.

Fig. 49.1 (A–C) Axial contrast-enhanced CT images show multiple, well-defined, low-density focal lesions in the spleen. Also seen are thickening of the stomach wall, enlarged retroperitoneal abdominal lymph nodes, and a left pleural effusion.
Radiologic Findings
Contrast-enhanced axial computed tomography (CT) scans show multiple low-density lesions in the spleen, along with diffuse thickening of the stomach, left pleural effusion, and enlarged abdominal lymph nodes (Fig. 49.1).
Diagnosis
Secondary involvement of the spleen in lymphoma
Differential Diagnosis
- Splenic metastases
- Splenic abscesses
- Spleen primary tumor
- Splenic infarcts
- Sarcoidosis
Discussion

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