Changes in Bone Density: Increased


Changes in Bone Density: Increased

Table 5.91 Bone density: increased density (osteosclerosis)




Osteosclerosis of premature infants and neonates

Generalized increased density of all the bones.

Physiologic variant with no clinical signs. Normalizes within the first 3 mo.

Bone infarcts

Fig. 5.36, p. 519

Patchy regions of increased sclerosis that may coalesce.

Bone infarcts after steroid therapy for inflammatory conditions or tumor treatment. Sickle cell disease.

Renal osteodystrophy with secondary hyperparathyroidism

Fig. 5.69, p. 542

Diffuse sclerosis with trabecular thickening.

Vitamin D–resistant rickets on vitamin D therapy

Fig. 5.62, p. 537

Increased density of diaphyses and metaphyses.

During therapy, sclerosis develops at sites of prior lucency.

Intrauterine infections

Increased diaphyseal and metaphyseal density.

Celery stalk pattern of the metaphyses. Congenital rubella and cytomegalovirus infections.

Osteopetrosis (Albers-Schönberg disease)

Fig. 5.67, p. 540

Fig. 5.80, p. 549

Generalized increase in bone density.

Sclerosis obliterates bone marrow preventing hematopoiesis.

Hypervitaminosis D

Increased metaphyseal cortical density, particularly at the diaphyseal junction.

After long-term ingestion of high doses of vitamin D.

Williams-Beuren syndrome (Williams syndrome)

(see Table 5.45 )


Combined picture of osteomalacia, osteoporosis, and osteosclerosis.

Excessive consumption of fluoride. Bone pain and arthralgias. Calcification of ligaments.


Fig. 5.9, p. 498

Marked cortical thickening and characteristic dripping candle wax appearance.

Localized painful swelling and growth disturbances. Follows distribution of dermatomes.

Primary hypertrophic osteoarthropathy

(see Table 5.56 )

Endosteal hyperostosis (van Buchem and Worth types)

(see Table 5.56 )


Generalized bone sclerosis and mild modeling deformity of the bones.

Short-limbed dwarfism with generalized increase in bone density. Brittle bones. Acroosteolysis.

Diaphyseal dysplasia (Camurati-Engelmann disease)

(see Table 5.56 )

Erdheim-Chester disease (polyostotic sclerosing histiocytosis)

Usually affects adults. Progressive and widespread patchy sclerosis of the intramedullary region of bones with loss of the corticomedullary junction. Coarse trabecular architecture. Focal rib lesions.

Primary hyperoxaluria (oxalosis)

Osteoporosis in the early phase and diffuse bone sclerosis in the advanced stage. Subchondral sclerosis in the long bones. Metaphyseal sclerosis, dense epiphyses.

Growing ends of bones show bulbous enlargement. Pathologic fractures are common. Growth disturbance and increased incidence of urinary calculi due to hyperoxaluria.

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Jul 12, 2020 | Posted by in PEDIATRIC IMAGING | Comments Off on Changes in Bone Density: Increased

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