Intravenous contrast for CT or MR
Double contrast barium enema
TOP DIFFERENTIAL DIAGNOSES
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Adenocarcinoma
Short, focal, “apple core” lesion < 10 cm in length
More likely to cause colonic obstruction than submucosal lymphoma or mets
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Gastrointestinal stromal tumor
PATHOLOGY
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Metastatic spread from melanoma or primary tumor of stomach, lung, or breast (rarely, other cancers)
Gastric cancer may directly invade transverse colon along gastrocolic ligament
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Lymphoma may arise from and be limited to colon