Esophageal Intervention in Malignant and Benign Esophageal Disease

Chapter 129


Esophageal Intervention in Malignant and Benign Esophageal Disease


Tarun Sabharwal, Stavros Spiliopoulos and Andreas Adam


With development and improvement of different technologies and devices, many diseases of the esophagus are now within the scope of minimally invasive interventional radiologic–guided procedures. In this chapter we describe the methods of imaged-guided intervention of benign and malignant conditions of the esophagus. Although endoscopy is helpful in confirming the diagnosis, it is unnecessary in the treatment of esophageal strictures under imaging guidance.


An esophageal stricture is a narrowing of the lumen caused by an abnormality of the esophageal wall. Strictures may be due to esophageal cancer or a range of benign conditions and may be associated with mucosal ulceration and fibrous scarring. Obstruction of the lower esophagus can be also caused by achalasia. The etiology of the stricture is determined by the patient’s signs and symptoms, the radiographic and endoscopic appearance of the stricture, esophageal pressure and acidity measurements in patients with suspected functional obstruction, and where appropriate, histologic examination of endoscopic biopsy specimens. Management of the stricture differs among the types.


Dysphagia is the most common symptom associated with esophageal strictures. Patients typically complain of solid-food dysphagia that may progress over time to include liquids. If patients present initially with solid and liquid dysphagia, a motility disorder rather than an anatomic abnormality should be suspected. Patients may also report symptoms of regurgitation or aspiration, chest pain, abdominal pain, or weight loss. Analysis of the patient’s symptoms can guide the clinician to the correct diagnosis in 80% of dysphagia cases.1


The diagnostic evaluation for these patients often begins with a barium esophagogram, which can help direct further endoscopic evaluation and intervention. The location, size, and complexity of the lesion, as well as the presence of associated abnormalities, influence the choice of therapy. If esophagography suggests that the stricture may be malignant, diagnostic endoscopy and biopsy are usually carried out.


Esophageal cancer is the sixth leading cause of death from cancer worldwide.2,3 Because patients may not experience dysphagia until the luminal diameter has been reduced by 50%, cancer of the esophagus is generally associated with late presentation and poor prognosis. The overall 5-year survival rate is less than 10%, and fewer than 50% of patients are suitable for resection at presentation.4,5 The aims of palliation are maintenance of oral intake, relief of pain, elimination of reflux and regurgitation, prevention of aspiration, and minimization of hospital stay.68 Current palliative treatment options include thermal ablation,9 photodynamic therapy,10 radiotherapy,11 chemotherapy,12 chemical injection,13 argon beam or bipolar electrocoagulation,14 enteral feeding (nasogastric tube/percutaneous endoscopic gastrostomy),15 and intubation using either self-expanding metal stents (SEMS) or semirigid plastic tubes.7,8 Esophageal prostheses have been in use for over a century. Different tubes of the pulsion and traction variety have been described. The earliest device, made of decalcified ivory, was designed by Leroy d’Etiolles in 1845. The first metal esophageal prosthesis was introduced by Charters J. Symonds in 1885.16 Modern esophageal stenting utilizes either rigid plastic tubes or SEMS.



Indications


Benign Esophageal Strictures


Benign strictures of the esophagus occur as the result of collagen deposition and fibrous tissue formation stimulated by esophageal injury. Peptic strictures, caused by esophageal exposure to gastric acid, account for 70% to 75% of benign esophageal strictures.17,18 Other common causes of benign strictures include Schatzki ring, ingestion of corrosive agents (including certain medications), external-beam radiation therapy, sclerotherapy, photodynamic therapy, reaction to a foreign body, infectious esophagitis, and surgical trauma.19,20



Corrosive Strictures


Corrosive strictures can be either diffuse or local. With diffuse corrosive strictures, strong alkali or strong acid—if the concentration, volume, and duration of contact are sufficient—can lead to necrosis, which may be deep and extend over a considerable area, sometimes leading to perforation. Within 3 weeks, fibrous scarring develops and leads to stricture formation, which is graded as follows:




Various tablets cause esophagitis locally if they adhere to the mucosa. This sometimes progresses to local stricture formation by fibrous scarring. Local strictures after corrosive tablet ingestion are usually short and not dense. They are easily dilated and may require only one course of bougienage or balloon dilation. Strictures caused by liquid corrosive may be more difficult to manage and are dealt with according to their grade. Grades I, II, and most of III can be treated by intermittent dilation, beginning 3 weeks after the injury. Dilation carried out earlier often leads to perforation. Initially, weekly dilations are necessary, but the treatment interval can be gradually prolonged if there is a good response. Tough grade III strictures and most long grade IV strictures may be difficult and hazardous to dilate, and surgery may be necessary.



Achalasia


Achalasia is an esophageal motor disorder characterized by increased lower esophageal sphincter (LES) pressure, diminished to absent peristalsis in the distal portion of the esophagus, and lack of a coordinated LES relaxation in response to swallowing.


Primary achalasia is the most common subtype and is associated with loss of ganglion cells in the esophageal myenteric plexus. These important inhibitory neurons induce LES relaxation and coordinate proximal-to-distal peristaltic contraction of the esophagus. LES pressure and relaxation are regulated by excitatory (e.g., acetylcholine, substance P) and inhibitory (e.g., nitric oxide, vasoactive intestinal peptide) neurotransmitters. Patients with achalasia have an imbalance in excitatory and inhibitory neurotransmission. The result is a hypertensive, nonrelaxing esophageal sphincter.


Secondary achalasia, which is relatively uncommon, is caused by conditions other than intrinsic disease of the esophageal myenteric plexus, such as certain malignancies, diabetes mellitus, and Chagas disease.




Diagnosis


The most important investigations in patients with achalasia are (1) barium esophagography, (2) esophageal manometry and pH studies, and (3) endoscopy. The main role of endoscopy is to rule out a tumor at the gastroesophageal junction (pseudoachalasia). Characteristic changes on esophagography include dilation of the esophagus and absence of peristaltic activity. A smooth narrowing in the distal esophagus (“bird’s beak” appearance) is characteristic but not always seen.


Esophageal manometry findings are characteristic and show lack of peristalsis, with waves that are mirror images of each other rather than true contractions (common-cavity phenomenon). Pressure in the LES is elevated in about half of cases, but relaxation of the sphincter is almost always abnormal, with approximately 75% of patients demonstrating absent or incomplete relaxation and 20% to 30% showing relaxation that is complete but very short (<6 seconds).


Endoscopy is essential to confirm the absence of structural abnormalities such as a stricture and, more importantly, to rule out a tumor in the region of the gastroesophageal junction, which can mimic achalasia but should not be treated with pneumatic dilation. Endoscopic ultrasound may be useful in some cases to rule out extramucosal tumor. This is particularly important in elderly patients with a short duration of symptoms and substantial weight loss.



Treatment


Treatment is directed toward symptomatic relief of the disorder, which is achieved by disrupting the muscle fibers of the LES, usually by using surgical cardiomyotomy or balloon dilation.21 The therapeutic results after either technique are broadly similar,4 but balloon dilation has several advantages: thoracic or abdominal surgery is avoided, the average hospital stay is shorter, and there is a lower incidence of subsequent esophageal reflux.22



Epidermolysis Bullosa


Epidermolysis bullosa (EB) is a very rare skin fragility disorder characterized by blister formation following minor mechanical trauma. The clinical subset varies from only mild skin reactions to severe mutilating deformities such as pseudosyndactyly and fatal forms, depending on the genotypic subtype of the disease. In severe types, gastrointestinal, urologic, and corneal abnormalities have been also noted.23 In general, two major categories are recognized: inherited (IEB) and acquisita (EBA). The inherited type is more common and can be divided into four principal types: EB simplex, dystrophic EB, junctional EB, and Kindler syndrome.24,25 It is calculated that IEB affects 1 to 3 births in every 100,000 live births; nearly 5000 patients in the United Kingdom suffer from the disease.26 EBA is an autoimmune primary blistering disease associated with immunoglobulin G (Ig) autoantibodies against type VII collagen, the basal membrane zone (BMZ) of the skin and the malpighian mucosa. Collagen VII is a major component of esophageal epithelium, so high-grade esophageal strictures resulting in severe dysphagia and malnutrition are noted in various EB subtypes. Esophageal involvement is more frequent in the recessive dystrophic EB subtype; almost 70% of these patients will develop at least one esophageal stricture by the age of 25.27



Diagnosis


Diagnosis of esophageal involvement in patients suffering from EB is based on clinical symptomatology (various grades of dysphagia) and can be radiologically documented with a barium esophagogram. Typical EB stenotic lesions are present in the upper esophageal segments at the level of C5-C7 and can be either smooth, usually short stenotic lesions or weblike, tight, focal, fibrotic strictures.28 High strictures are more frequent because of the physiologic narrowing of the upper part of the esophageal canal, which is therefore more exposed to mechanical trauma during deglutition; however, stenosis of the lower parts of the esophagus are also possible. A differential diagnosis of a true weblike stricture and the presence of transient indentation of the anterior cricopharyngeal wall should be obtained.



Treatment


Treatment options for the esophageal stenosis include conservative medical management in the acute phase using steroids and phenytoin, esophageal dilation, and surgical replacement. With the latter being reserved only for few selected cases, fluoroscopically-guided or endoscopic balloon dilatations are the most common management methods of dysphagia in EB. However, fluoroscopically guided dilatation offers a less traumatic approach because the lesion is crossed using floppy guidewires, in contrast to endoscopic dilatation, which may cause a significant degree of pharyngoesophageal trauma while advancing the endoscope. In addition, the procedure can be performed under heavy sedation without use of an artificial airway when intubation is impossible or not deemed necessary by the anesthesiologist. In cases where a gastrostomy tube is in place, the procedure can also be performed retrograde via the preexisting tube. Use of balloons ranging from 18 to 26 mm in diameter has been reported to be safe and effective.29




Esophageal Strictures in Children


Esophageal strictures occur in 40% of children after surgical repair of esophageal atresia. The main causes are fibrosis subsequent to natural healing, size difference of the two anastomosed segments, tension, and gastroesophageal reflux. Leaks, as well as use of a two-layer anastomosis and/or silk sutures, increase the likelihood of stricture formation. Dilation is 90% effective, but strictures that do not respond to repeated dilation can be treated with temporary stenting—a technique still under evaluation—or with repeat surgery.


Esophageal atresia is a condition in which the proximal and distal portions of the esophagus do not communicate. The upper segment of the esophagus is a dilated blind-ending pouch with a hypertrophied muscular wall. This pouch typically extends to the level of the second to fourth thoracic vertebrae. The distal esophageal portion has a small diameter and a thin muscular wall; it extends a variable distance above the diaphragm.


Tracheoesophageal fistula is an abnormal communication between the trachea and esophagus. When associated with esophageal atresia, the fistula most commonly occurs between the distal esophageal segment and the trachea, just above the carina.


The frequency and severity of complications after repair of esophageal atresia are related to the extent of the repair required, with primary anastomosis and fistula closure being associated with fewer complications than esophageal replacement. The most common complications are anastomotic leak, recurrent fistula, stricture, and gastroesophageal reflux.




Malignant Esophageal Strictures


The main indications for esophageal stenting in malignant disease are:



• Intrinsic esophageal obstruction


• Tracheoesophageal fistula. Spontaneous malignant fistulas between the esophagus and major airways occur as a result of local tumor invasion from the esophagus or tracheobronchial tree (Fig. 129-1) or may be secondary to surgery or esophageal stent placement. Esophageal leaks or perforations are usually iatrogenic following esophageal dilation or surgery, but may also be caused by local tumor invasion. Leaks and fistulas in benign disease should not be stented because leakage occurs around the stent. In many such cases, there is spontaneous healing. However, without definitive treatment, malignant lesions will not heal, and most patients would die of malnutrition and thoracic sepsis within weeks. Until recently, therapy for malignant leaks and fistulas has been unsatisfactory. Attempted surgical repair has a high morbidity and mortality. Parenteral nutrition or feeding via a gastrostomy were often used, but continuing leakage of esophageal contents resulted in mediastinitis in many patients. Attempts to seal the esophageal defect with plastic stents were usually ineffective. Covered self-expanding metallic stents are the treatment of first choice in patients with malignant leaks and fistulas, because the metallic stent expands to the diameter of the esophagus, and the covering material seals the defect.



• Extrinsic esophageal compression by primary or secondary mediastinal tumors


• Esophageal perforation, usually iatrogenic, from direct endoscopic trauma or following stricture dilation


• Symptomatic gastroesophageal anastomotic leaks


• Anastomotic tumor recurrence after surgery



Contraindications


There are no absolute contraindications for intervention in esophageal disease. Relative contraindications should be considered for both benign and malignant disease:



Particular contraindications for foreign body removal by fluoroscopic balloon catheter removal, esophageal bougienage, and temporization include chest radiographic findings of esophageal edema with airway compromise, esophageal perforation, or pneumomediastinum. Most often, esophageal foreign bodies are retrieved with rigid esophagoscopy. Advantages include a high success rate, direct visualization of the foreign body in the esophagus, and direct visualization of the esophagus after removal of the object.



Equipment


Materials and Equipment







Stents


A wide variety of self-expanding metallic or plastic stents are used.



Nitinol Stents


Nitinol is composed of nickel (55%-56%) and titanium (44%-45%), which expands or contracts when its temperature is increased or decreased, respectively. As a result of a “shape memory effect” acquired during heat treatment of the raw material, stents made of nitinol return to a preset shape and size when they reach body temperature.


Dec 23, 2015 | Posted by in INTERVENTIONAL RADIOLOGY | Comments Off on Esophageal Intervention in Malignant and Benign Esophageal Disease

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