Follicular Bronchiolitis

Follicular Bronchiolitis

Jud W. Gurney, MD, FACR

Micropathology shows peribronchiolar image germinal centers image in a patient with follicular bronchiolitis.

Axial HRCT shows faint centrilobular nodules image and tree-in-bud opacities image. Follicular bronchiolitis was the diagnosis.


Abbreviations and Synonyms

  • Pulmonary lymphoid hyperplasia, lymphocytic interstitial pneumonia (LIP), lymphoid interstitial pneumonia

  • Diffuse hyperplasia of bronchus-associated lymphoid tissue (BALT), mucosa-associated lymphoid tissue (MALT)


  • Spectrum of lymphoid disorders

    • Follicular bronchiolitis to nodular lymphoid hyperplasia (pseudolymphoma), LIP, and lymphoma

  • Nonneoplastic lymphoproliferation must be differentiated from lymphoma by immunologic stains

    • Monoclonal cell lines in lymphoma, polyclonal in nonneoplastic lymphoproliferative disorders


General Features

  • Best diagnostic clue: Centrilobular nodules, faint

  • Patient position/location: Diffuse or lower lung zones

  • Size: Nodules < 3 mm in diameter

  • Morphology: Follicular bronchiolitis centered on airways (leads to centrilobular nodules), LIP more diffuse

CT Findings

Sep 20, 2016 | Posted by in RESPIRATORY IMAGING | Comments Off on Follicular Bronchiolitis

Full access? Get Clinical Tree

Get Clinical Tree app for offline access