Renal Inflammatory Disease

Renal Inflammatory Disease

Inflammatory disease involving the kidney can be divided into two broad groups: (1) glomerulonephritis, which involves an immunologic injury of the glomerulus, and (2) interstitial nephritis, which is the effect of an infectious or toxic agent on the renal parenchyma. Radiologic studies play a limited role in the diagnosis and management of glomerulonephritis (see Chapter 8). Interstitial nephritis is divided into two major subgroups: (1) noninfectious interstitial nephritis, which is usually caused by the action of toxic agents on the kidney, and (2) infectious interstitial nephritis, which is the result of the action of a pathogen. In most cases, infectious interstitial nephritis is caused by a bacterial organism and is called acute pyelonephritis. This chapter will concentrate on renal infections.


Imaging Approach to Renal Inflammatory Disease

In most cases of urinary tract infection, imaging is not indicated. But if there is incomplete or slow response to therapy, multiple repeated infections, immune compromise (especially due to diabetes mellitus), or history of any condition, which may have altered
urinary tract anatomy (surgery, vesicoureteral reflux, stones), renal imaging studies are often required for diagnosis and management. The rationale for performing an imaging study is not only to diagnose acute pyelonephritis but also to look for an underlying anatomic abnormality that may have predisposed the patient to the infection, to search for a calculus or an obstruction that may prevent a rapid therapeutic response, or to diagnose a complication of the infection such as a renal or perinephric abscess. If the investigation is confined to those patients whose fever does not lyse within 72 hours of appropriate antibiotic therapy, the proportion of patients with findings that have immediate clinical significance increases significantly.

Contrast-enhanced computed tomography (CT) or CT urography (CTU) is the imaging study of choice for the diagnosis of acute pyelonephritis or to look for a potential complication of the infection such as a renal or perinephric abscess or emphysematous pyelonephritis.

Conventional gray scale ultrasound detects most instances of abscess, obstruction, and stones in infected patients and sometimes can suggest pyonephrosis by detecting small particles in infected urine but may fail to detect these abnormalities if they are minor or if the patient is difficult to examine. Sonography is less sensitive than CT in revealing foci of inflamed renal parenchyma, although its accuracy can be improved with ultrasound contrast agents. The modality is safe and relatively inexpensive and can diagnose most of the abnormalities that require specific treatment and thus remains a commonly used technique for patients with renal infection.

Other imaging studies are of value in selected patients. Magnetic resonance imaging (MRI) may demonstrate infected regions of the renal parenchyma to enhance abnormally and to have restricted diffusion and can demonstrate obstruction and abscesses but often fails to reveal small stones; the technique should be reserved for patients who cannot undergo contrast-enhanced CT examinations. Retrograde pyelography may serve as both diagnostic and planning maneuvers in patients with obstructive pyonephrosis who are to be treated with ureteral stents or percutaneous nephrostomy tubes, respectively. Voiding cystourethrography is used to demonstrate vesicoureteral reflux but is performed only rarely in adults.

In children with multiple urinary tract infections, the classic imaging approach involves searching for reflux and other bladder and urethral abnormalities with voiding cystourethrography. Demonstration of reflux often leads to a search for renal infection and scars with renal scintigraphy (usually with technetium-99m dimercaptosuccinic acid [99mTc-DMSA]) and/or renal gray scale and Doppler ultrasound. There is a growing tendency to use a “top-down” approach to imaging, in which renal abnormalities are sought with ultrasound or scintigraphy, and efforts to diagnose reflux are reserved for patients with renal findings that suggest it. Professional society guidelines are not unanimous on this issue.

FIGURE 7.1. Acute pyelonephritis. An unenhanced CT demonstrates diffuse parenchymal swelling.

FIGURE 7.2. Acute pyelonephritis. A: There is inflammation in the fat posterolateral to the right kidney (arrow); the right kidney is enlarged, and there are patchy regions of diminished and heterogeneous enhancement of the cortex. B: A coronal projection from an enhanced CT in another patient. Patchy opacification is seen in the right kidney.

Acute Pyelonephritis

The imaging examination providing the most complete information regarding the nature and extent of the inflammatory process is contrast-enhanced CT. Unenhanced scans may be normal or show only renal enlargement (Fig. 7.1); there may be perinephric stranding from inflammation or edema (Fig. 7.2), and Gerota’s fascia may be thickened. After intravenous contrast administration, areas of decreased contrast enhancement appear (Figs. 7.2 and 7.3). These regions may be inhomogeneous or striated and their distribution is variable. They may be solitary or multiple and unilateral or bilateral and may involve little or most of the renal parenchyma. The distribution is typically patchy. Diffuse homogeneous involvement of the renal parenchyma is rare and is likely to appear only when there is ureteral obstruction. If delayed scans are obtained, the abnormal areas may reveal a dense nephrogram, which persists
after the normal parenchyma has lost its enhancement (Fig. 7.4). Differential diagnosis of regions of diminished or inhomogeneous enhancement may include acute ischemia or contusion; if there is focal swelling, a focus of acute pyelonephritis may resemble an infiltrating tumor (tumefactive pyelonephritis). Clinical data often permit a specific diagnosis. Acute ischemia may be indicated by the peripheral rim sign or visible vascular abnormalities and produce fewer changes than pyelonephritis in the perinephric fat. The pyelitis which sometimes accompanies renal infection may be reflected by thickening of the walls of the collecting system (Fig. 7.5).

FIGURE 7.3. Acute pyelonephritis. Relatively narrow striated areas of decreased enhancement are seen in the right kidney.

The appearance of pyelonephritis on CT may be modified by antibiotic therapy. Partially treated patients may demonstrate a rounded or ovoid area of decreased enhancement with poorly defined margins (Fig. 7.6). Long-term follow-up studies in patients with mild disease may show a return to normal renal morphology and enhancement (Fig. 7.7). With more severe disease, focal atrophy may appear at the sites of previous infection (Fig. 7.8) and there may be focal calyceal clubbing, suggestive of papillary necrosis. The etiology of these morphologic changes has been postulated to involve ischemic insult to the kidney as a result of the inflammatory process. Ultrasound in patients with acute uncomplicated pyelonephritis may be normal or show diffuse or focal renal enlargement with regions of increased or decreased echogenicity of the renal parenchyma (Fig. 7.9). Perinephric inflammation may produce a thin layer of extracapsular fluid adjacent to the infected portions (Fig. 7.10). The normal corticomedullary differentiation may be lost. Doppler ultrasound may reveal focal regions of abnormal perfusion (Fig. 7.9); although there is hyperemia of the affected regions, the normal renal parenchymal flow is so high that the infected regions may have less flow than surrounding normal tissue, perhaps due to elevated interstitial pressure from edema.

FIGURE 7.4. Acute pyelonephritis; delayed CT. The abnormal regions are revealed by wedge-shaped regions of retained parenchymal contrast.

FIGURE 7.5. Pyelitis. The wall of the right renal pelvis (arrows) is thickened.

FIGURE 7.6. Atypical appearance produced by treated pyelonephritis. CT shows a rounded area of decreased enhancement in the right kidney without significant mass effect; this is in contrast to the striated areas more typical of untreated acute pyelonephritis.

FIGURE 7.7. Acute pyelonephritis. A: Before treatment, the kidney is severely affected, with regions of markedly reduced enhancement. B: After treatment, morphology and enhancement are normal.

FIGURE 7.8. Acute pyelonephritis. A: Before treatment, the left kidney is swollen and has a diminished inhomogeneous nephrogram. B: Several months after treatment, the left kidney is smaller than normal and has focal cortical scars.

FIGURE 7.9. Acute pyelonephritis. A: The affected upper pole is abnormally echogenic (arrows). B: The abnormal region reveals diminished Doppler flow when compared to the normal parenchyma. C: CT confirms focal pyelonephritis.

FIGURE 7.10. Acute pyelonephritis. There is a thin layer of pericapsular fluid (arrow).

The MRI findings are morphologically similar to those seen on CT and reflect swelling, altered perfusion, and focal areas of diminished enhancement (Fig. 7.11). Diffusion-weighted images reveal restricted diffusion in the affected portions (Fig. 7.11) and may be more sensitive than either T2-weighted or contrastenhanced T1-weighted images (Fig. 7.12) for detecting regions of pyelonephritis.

Radionuclide imaging in patients with acute pyelonephritis has been reported using renal cortical imaging agents, such as 99mTc-DMSA, and agents that image inflammation, such as gallium (67Ga) citrate. Renal cortical imaging studies may show an inhomogeneous distribution of the radionuclide within the affected kidney or polar defects with asymmetric tracer uptake.

Chronic Pyelonephritis

The term chronic focal atrophic pyelonephritis applies to renal parenchymal scarring in which the cortex and medulla are focally thinned and the underlying calyces are blunted. This appearance may have a number of causes, including vesicoureteral reflux, calyceal stones, or severe focal pyelonephritis (Figs. 7.8B and 7.13). Once the scars have appeared, the gross pathologic and radiologic appearance of the affected kidney does not allow determination of the cause; microscopy reveals focal fibrosis in all cases. If the etiology is known to be vesicoureteral reflux, the term reflux nephropathy is used. It is thought that as urine refluxes during bladder contractions, the hydrostatic pressure in the collecting system rises transiently, and the urine, which is often infected, flows retrograde into the collecting tubules of the kidney (pyelotubular backflow or reflux). Such intrarenal reflux occurs in a patchy distribution, possibly because of local differences in the papillary openings of the collecting ducts of the renal medullae, which in turn is probably responsible for the focal nature of the resultant scarring. Within the scarred regions, dense fibrous tissue replaces normal nephrons (Fig. 7.14).

FIGURE 7.11. MRI of acute pyelonephritis. T2-weighted image (left) shows overall increase in intensity and a striated pattern in the infected right kidney. Diffusion-weighted image (right) reveals restricted diffusion in the same distribution.

FIGURE 7.12. Acute pyelonephritis. Contrast-enhanced T1-weighted image with fat saturation reveals regions of poor or absent perfusion in the right kidney.

Calyceal stones, possibly by causing elevated calyceal pressure due to infundibular obstruction or by acting as foci of infection, frequently cause calyceal clubbing and scars that are indistinguishable from reflux nephropathy (Fig. 7.15). When chronic pyelonephritic scarring is found in middle-aged or elderly patients, stones are most likely to be the cause; in children, reflux has usually produced the
scars. Focal infarction may produce similar scars; however, calyceal blunting is less likely to be found in this condition. Trauma, including surgery, and radiation therapy, which includes portions of the kidney (Fig. 7.16), may also produce scars.

FIGURE 7.13. Acute pyelonephritis. The arrows indicate the affected region, which is swollen and displays diminished enhancement. Scar after treatment (left). The renal parenchyma in the affected region (arrows) is atrophic and enhances less than normal parts of the kidneys (right).

The radiologic findings of chronic pyelonephritis on CT, CTU, and MRI include the demonstration of one or more parenchymal scars (Fig. 7.17) overlying a deformed calyx. If parenchymal loss has been severe, focal areas of compensatory hypertrophy may be seen adjacent to the areas of cortical scarring. These may mimic solid parenchymal tumors but can be distinguished from tumors by observing that when contrast is administered, they enhance to the same degree as adjacent normal parenchyma.

FIGURE 7.14. Chronic atrophic pyelonephritis. T2-weighted image (top) and T1-weighted gadolinium-enhanced fat-saturated image (bottom) reveal focal region of parenchymal thinning (arrows) representing a fibrotic scar.

FIGURE 7.15. A calyceal stone is visible in a noncontrast CT (left). Parenchymal scars (white arrows) are seen without contrast and in a CT urogram (right). The urogram shows the stone as a filling defect (black arrow) in the opacified collecting system; the calyces are blunted.

FIGURE 7.16. Radiation-induced scar. The medial aspect of the kidney (arrows) was included in a radiation therapy field several years earlier and is now atrophic and has diminished opacification.

FIGURE 7.17. Chronic focal atrophic pyelonephritis due to childhood reflux. The left kidney is small and demonstrates focal parenchymal loss (arrow) with a blunted calyx.

Ultrasound changes in patients with chronic atrophic pyelonephritis include focal loss of parenchyma, which can be appreciated on longitudinal or cross-sectional images. Increased echogenicity in the area of the scar may also be demonstrated. The central renal sinus echoes may extend to the periphery of the kidney in the area of abnormality. In contrast to other causes of generalized increased cortical echogenicity, the process appears focal.

Acute Renal Abscess

Renal abscesses form as a result of the coalescence of microabscesses that are often present in acute pyelonephritis. The predominant organisms responsible for abscesses are gram-negative enteric species. Patients with diabetes mellitus, drug abuse, vesicoureteral reflux, or renal calculus disease are most susceptible to abscess formation. Acute abscesses may be solitary or may form simultaneously in multiple locations in the kidney. Multiple lesions are less common and suggest hematogenous dissemination.

The signs and symptoms of an acute renal abscess are difficult to distinguish from those of pyelonephritis, and the diseases often coexist. Fever, leukocytosis, pyuria, and flank pain are common in both. There is frequently a history of prior antibiotic therapy with recrudescence of symptoms on cessation of treatment. Renal abscesses appear as a continuum of conditions. Acute pyelonephritis may progress to a cluster of small abscesses, which may or may not coalesce, so that there may be a single fluid-filled cavity, a multiloculated cavity, or a phlegmonous region in which a network of solid tissue planes separate multiple small abscesses. When fibroblasts migrate into the area of an acute renal abscess and form a barrier between the abscess and the remainder of the kidney, a chronic renal abscess is formed. This may result in a transition zone of inflammatory tissue between the liquid center of the abscess and the normal renal parenchyma.

On sonography, abscesses appear as relatively sonolucent lesions with differing amounts of solid tissue echoes; the pus may contain low-amplitude echoes (Fig. 7.18) and there may be gas bubbles. There is usually enhanced through-transmission of the ultrasound beam. Doppler studies show no flow in the necrotic pus-filled regions; the amount of flow in the wall is variable.

CT is the imaging study of choice for the diagnosis of an acute renal abscess. The lesion is a low-attenuation (10 to 20 HU) rounded or ovoid mass that does not enhance with contrast administration (Fig. 7.19). As a result of the surrounding inflammatory process, the borders of the mass are usually indistinct; the degree
of enhancement of the abscess wall is variable. The presence of gas within a pocket of fluid is virtually pathognomonic of an abscess. There is usually thickening of Gerota fascia, and increased density may be found in the adjacent perinephric and mesenteric fat. The abscess may or may not extend into the perinephric space. MR findings reflect those seen on CT. The center of the abscess has the characteristics of fluid, and the periphery of the lesion, which is of varying thickness, enhances to varying degrees (Figs. 7.19 and 7.20). Radionuclide scanning with technetium-labeled DMSA is occasionally used but has largely been replaced by CT.

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Oct 30, 2018 | Posted by in NUCLEAR MEDICINE | Comments Off on Renal Inflammatory Disease
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