Renal Osteodystrophy

 Blurred, coarse bone trabeculae



• Changes of hyperparathyroidism (HPT)
image Prominent primary trabeculae

image Resorption of secondary trabeculae

image Cortical thinning

image Erosions at entheses, endplates, sacroiliac (SI) joints

image Brown tumors: Lytic lesion, no matrix, sharp zone transition




Top Differential Diagnoses




• Primary hyperparathyroidism

• Osteomalacia and rickets

• Dialysis arthropathy

• Osteopetrosis

• Paget disease

• Discogenic sclerosis


Pathology




• Secondary hyperparathyroidism
image Phosphate retention by kidneys → ↓ serum calcium →↑ parathyroid hormone (PTH)

image ↑ parathyroid hormone (PTH) → ↑ bone resorption

• Osteomalacia

• Soft tissue calcifications


Clinical Issues




• Asymptomatic unless pathologic fracture occurs

image
(Left) Lateral radiograph shows severe findings of renal osteodystrophy. There is marked sclerosis of the vertebral bodies adjacent to the endplate creating a striped appearance like a rugby jersey. The margins of the sclerosis are poorly defined, in distinction to the sharply demarcated sclerotic regions seen in osteopetrosis.


image
(Right) Lateral radiograph shows fairly mild changes of renal osteodystrophy (OD). Ill-defined sclerosis is present adjacent to the endplates, and bony trabeculae are blurred.

image
(Left) Anteroposterior radiograph in the same patient shows sacroiliac erosions image due to 2° hyperparathyroidism. Accelerated arterial calcifications image are due to the abnormal calcium/phosphate levels.


image
(Right) Axial bone CT through the thoracic spine shows sclerosis image and blurred trabeculae due to renal osteodystrophy. The appearance is more uniform and diffuse than that of sclerotic metastases.


TERMINOLOGY


Abbreviations




• Renal osteodystrophy (OD)


Definitions




• Chronic kidney disease-mineral and bone disorder (CKD-MBD): Constellation of abnormalities seen in progressive kidney disease, including metabolic abnormalities, disturbances in bone modeling and remodeling, and extraskeletal calcification in arteries and soft tissues

• Renal osteodystrophy (OD): Only defines bone pathology associated with CKD


IMAGING


General Features




• Best diagnostic clue
image Rugger jersey spine

• Location
image Involves axial and appendicular skeleton

Oct 5, 2016 | Posted by in NEUROLOGICAL IMAGING | Comments Off on Renal Osteodystrophy

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