22 Tracheobronchial Amyloidosis

CASE 22


image Clinical Presentation


56-year-old woman with cough


image Radiologic Findings


Contrast-enhanced chest CT (mediastinal window) (Figs. 22.1A, 22.1B) demonstrates abnormal soft tissue extending anterolaterally along the tracheal wall and narrowing the lumen. Note the absence of soft-tissue infiltration/obliteration of peritracheal tissue planes.


image Diagnosis


Tracheobronchial Amyloidosis


image Differential Diagnosis


• Primary and Secondary Neoplasia (e.g., adenoid cystic carcinoma, tracheal metastases)


• Wegener Granulomatosis


• Tracheobronchopathia Osteochondroplastica



image


Fig. 22.1


image Discussion


Background


Amyloidosis is a rare disease that may affect the lung or tracheobronchial tree. It may occur as a primary lesion or as secondary amyloid deposition in association with chronic disease. Tracheobronchial involvement is the most common and severe form of thoracic amyloidosis. Primary tracheal amyloidosis is rare and usually involves the trachea in a slow and indolent manner.


Etiology


The etiology of tracheobronchial amyloidosis is unknown. Chronic diseases associated with secondary amyloidosis include rheumatoid arthritis, Crohn disease, ankylosing spondylitis, tuberculosis, bronchiectasis, and familial Mediterranean fever.


Clinical Findings

Jan 14, 2016 | Posted by in RESPIRATORY IMAGING | Comments Off on 22 Tracheobronchial Amyloidosis
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