Clinical application of radiation dose optimization and image optimization in radiology



1.15: Clinical application of radiation dose optimization and image optimization in radiology


Avinash U Sonawane, V. Anuradha, Anand Pinjarkar



Introduction


X-ray radiation for diagnosis is widely used application of ionizing radiation in medicine, in terms of both the number of existing institutes/facilities and the number of persons who are exposed for clinical investigations. As per the global data published by United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), 2020/21, about 4.2 billion medical radiological examinations were performed annually, leading to individual annual average dose of 0.57 mSv. Medical X-ray exposures account for 99% of the contribution from all artificial radiation sources.


This is not surprising as X-ray-based diagnostic radiology equipment encompass a wide gamut of practices ranging from the general-purpose radiography (fixed or mobile), fluoroscopy, computed tomography (CT), cath lab, C-arm, intraoral periapical X-ray, orthopantomography and cone beam CT used in dental departments and other diagnostic equipment such as mammography and bone mineral densitometer (or dual-energy X-ray absorptiometry). All these equipment are internationally termed as “medical radiological equipment”.


The CT scan equipment, in particular, has become a ubiquitous diagnostic modality in a hospital, owing to its versatility and practicality. It is also commonly used in emergency departments for accident victims for quick triage. CT is also useful for cancer treatment planning with use of positron emission tomography–CT for detailed information about cancer and CT simulation for delineating target volume and sensitive organs for radiation therapy.


In CT scans, series of X-ray images are taken around the body, and combining these images by computer processing creates cross-sectional images. CT is based on variable absorption of X-rays by different tissues, and the principle of working is similar to radiography or fluoroscopy equipment. However, the imaging in CT technology is very different from that of radiography or fluoroscopy. A CT imaging system produces cross-sectional images or “slices” of anatomy, which are then effectively used for accurate diagnosis of disease.


CT systems are capable of “spiral” or “helical” scanning as well as conventional “axial” or “sequential” scanning. Many CT systems are capable of imaging multiple slices simultaneously, which allows imaging of large volumes of anatomy in relatively less time. Over the years, there has been great advancements in the CT technology, such as improvements in speed and image quality. The image reconstruction techniques have contributed significantly in reduction of radiation dose to the patient as compared with erstwhile CT scanners.


Radiation protection


With all its undeniable benefits in terms of timely diagnosis, the CT scan equipment stands as the one diagnostic modality with the potential to deliver substantial radiation exposures to the patient. The scattered radiation from the patient’s body could expose the radiological medical practitioners (RMPs)1/medical radiation technologists (MRTs)/other medical personnel (e.g. anesthetists) working in close proximity of the equipment. The radiation could also expose the general public in the vicinity of equipment room.


X-rays are ionizing radiation, which deposits its energy in the tissues and bones in the human body. For the patient undergoing diagnosis, the X-rays emitted directly from the equipment (termed as primary radiation) result in differential absorption and are reflected in an X-ray image. There are two types of adverse health effects of ionizing radiation: the deterministic effects and the stochastic effects. Deterministic effects relate to direct killing of cells by radiation resulting into damage to organism and include (at higher doses) skin erythema, epilation and ulceration/necrosis. Stochastic effects relate to genetic damage of cells and modifications in germ cells, leading to mutation resulting into carcinogenesis and hereditary effects. The probability of occurrence of stochastic effects increases with dose, while severity of deterministic effects increases with dose. The radiological risk associated with various types of radiology equipment varies significantly. At the low-risk end are dental exposures (excluding cone beam computed tomography) and bone densitometry studies. At the high-risk end are CT scans and image-guided interventional procedures where radiation injury may occur.


As with CT and most other diagnostic equipment, there exists primarily the consequence of stochastic effects. Deterministic effects are not prevalent in this modalities. The exception is cath lab, wherein certain radiological procedures require continuous X-ray exposures to the affected parts of body for appropriate diagnosis/treatment. This has, in certain instances, resulted in development of radiogenic effects in patient, i.e. skin erythema, deep cell squamation, etc.


There is a possibility that RMP/MRT and general public in the vicinity get exposed to the scattered radiation from the patient body, which is, however, substantially lesser than the primary radiation. In addition, there is a small amount of radiation leakage from the CT equipment, which contribute to the exposure of RMP/MRT and general public in the vicinity. The cohort of people receiving these exposures are different. Hence, these are classified as follows:




  1. (a) Occupational exposures (to the RMP/MRT/other medical personnel)
  2. (b) Public exposures (to the general public visiting the hospital)
  3. (c) Medical exposures (to the patient undergoing radiological procedure)

All the aforementioned exposures should be kept minimum without compromising in acquiring the desired clinical information. For achieving this, the team of persons performing radiological procedure should be qualified, trained and competent.


Terms explaining radiation dose


The following paragraph gives a brief primer of the radiological quantities and units used to explain radiation dose, which is important to be able to interpret and assess the extent of radiation protection to the three cohorts mentioned earlier.




  1. (a) Exposure: The term exposure describes the amount of ionization produced per unit mass of air. The unit of exposure is the coulomb per kilogram (C/kg) or R (roentgen). Exposure of 1 R is equivalent to ion pair produces of charge 1 C (coulomb) in a kilogram of an air. Exposure is an indicator for energy converted to ionization but not for energy absorbed in the system.
  2. (b) Air kerma: X-ray tube output can be expressed in terms of the air kerma (kinetic energy released per unit mass), which is measured in free air. Kerma is defined as the sum of the initial kinetic energies of all the charged particles liberated by uncharged ionizing radiation (such as photons and neutrons) in a sample of matter, divided by the mass of the sample. The unit of kerma is joule per kilogram (J/kg) or gray (Gy).
  3. (c) Absorbed dose: The absorbed dose is the amount of energy absorbed in a system. When radiation passes through human body, it deposits energy. The energy absorbed from exposure is called as absorbed dose. Unit of absorbed dose is joule per kilogram (J/kg) or Gy (gray). From physics perspective, dose of one Gy is equivalent to a unit of energy (unit of energy is joule) deposited in a kilogram of a matter.
  4. (d) Equivalent dose: There are different types of ionizing radiation (e.g. alpha particles, gamma radiation, X-ray radiation, etc.). If the same body part is exposed to two different types of ionizing radiation, the biological damage produced will not be the same. For example, alpha radiation produces dense or more ionization in a given path as compared with X-ray radiation. Therefore, same body part is exposed to alpha radiation and X-ray radiation, and the biological damage produced will not be the same. In this case, 1 Gy of alpha radiation is more harmful as compared with 1 Gy of X-ray radiation. To reflect this behaviour for different types of radiation, a term radiation weighting factor (WR) is used. A radiation weighting factor is used to equate biological effectiveness for different types of radiation. For X-rays, WR = 1. When absorbed dose is multiplied with radiation weighting factor, we get equivalent dose. The unit of equivalent dose is Sv (sievert).
  5. (e) Effective dose: Different tissues and organs of human body do not show same biological effectives for same amount of equivalent dose. Some are more sensitive to ionizing radiation and some are less sensitive. Such behaviour is called radiation sensitivity. For example, fast dividing cells such as bone marrow (red), colon and breast are more radiation sensitive as compared with brain, bone surface and skin. More radiation-sensitive tissues and organs exhibit higher biological effectiveness as compared with less radiation-sensitive tissues and organs. The radiation sensitivity is indicated by tissue weighting factor (WT).

The values of tissue weighting factors recommended in International Commission on Radiation Protection (ICRP) Report No. 103 are given as follows:
























































Tissue Tissue Weighting Factor
Bone marrow (red) 0.12
Breast 0.12
Colon 0.12
Stomach 0.12
Lung 0.12
Gonads 0.08
Thyroid 0.04
Liver 0.04
Oesophagus 0.04
Bladder 0.04
Brain 0.01
Bone surface 0.01
Salivary glands 0.01
Skin 0.01
Remainder tissues: adrenals, gall bladder, extrathoracic region, kidney, heart, lymphatic nodes, muscles, oral mucosa, pancreas, small intestine, spleen, thymus, prostate (in male), uterus/cervix (in female) 0.12
Total 1.00

Source: http://www.icrp.org/publication.asp?id=ICRP%20Publication%20103.


For example, if lung and brain are exposed to radiation separately and equivalent dose to the organs is 100 mSv each, then the effective dose is (100 mSv × 0.12) + (100 mSv × 0.01) = 13 mSv. Therefore, the risk of harmful effects from this radiation would be equal to 13 mSv dose delivered uniformly throughout the whole body.


Regulatory body in India governing radiation safety


Atomic Energy Regulatory Board (AERB) is the national regulatory body in India, which exercises regulatory control over all the medical radiological equipment, from radiation safety view point. Accordingly, safety licence from AERB is mandatory for operations of any radiological equipment. Licence is issued under the provisions of the Atomic Energy (Radiation Protection) Rules, 2004, promulgated under the Atomic Energy Act, 1962. For issuance of licenses, AERB has deployed efficient and transparent web-based licensing system named as electronic Licensing of Radiation Applications (eLORA).


AERB stipulates requirements to be met to ensure radiation safety in operation of X-ray equipment in its Safety Code entitled, “Radiation Safety in Manufacture, Supply and Use of Medical Diagnostic X-Ray Equipment”, AERB/RF/SC-3 (Rev-2) 2016. For obtaining AERB licence, the mandatory requirements are, appropriate layout and shielding of the X-ray room, qualified personnel, personnel monitoring, personnel protective equipment (such as protective barrier, aprons, gloves, thyroid shield, gonad shield, protective goggles). Also, the X-ray equipment shall be type approved (i.e. design approved) by AERB. Procuring the AERB-type approved equipment ensures built-in safety features and intended operational performance as per the prescribed quality assurance protocols.


AERB has stipulated effective dose limits to the radiation workers and general public as follows:




  • For occupational exposure of workers, an effective dose of 30 mSv in any single year and 20 mSv/year averaged over 5 consecutive years.
  • For public exposure, an effective dose of 1 mSv in a year.

Medical exposures


Medical exposures are delivered to individuals (patients) undergoing diagnostic (X-ray or nuclear medicine) examinations, radiological interventional procedures or radiation therapy. The exposure is intentional and for the direct benefit of the patient. It is important to note that specific dose limits are not applicable to medical exposures (i.e. radiation exposure to patients). However, they are governed by principles of radiation protection, i.e. (1) justification, (2) optimization and (3) dose reference levels.


International Commission on Radiation Protection (ICRP) in its Report No. 103 gives emphasis on the justification of the medical exposure and on the optimization of protection. ICRP recommends principle of justification at three levels:




  1. 1. The use of radiation in medicine is accepted as doing more good than harm to the patient.
  2. 2. A specified procedure with a specified objective is defined and justified. The aim of the second level of justification is to judge whether the radiological procedure will usually improve the diagnosis or treatment or will provide necessary information about the exposed individuals. It considers other factors such as justification of current technology and techniques verses new technologies and techniques, risk and effectiveness of existing and new procedures, and possible accidental or unintended exposures.
  3. 3. The application of the procedure to an individual patient should be justified (i.e. the particular application should be judged to do more good than harm to the individual patient).

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Mar 25, 2024 | Posted by in CARDIOVASCULAR IMAGING | Comments Off on Clinical application of radiation dose optimization and image optimization in radiology

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