87 Contrast Media: Gd Chelates with Protein Binding

By slight changes in structure, agents with improved relaxivity and altered distribution have been developed. MultiHance, which demonstrates transient protein binding, has 40% higher relaxivity (equivalent to double dose) and partial hepatobiliary excretion, due to addition of a phenyl moiety. Figure 87.1 illustrates the improved enhancement of a brain metastasis at 1.5 T with MultiHance (Fig. 87.1B) compared with that of a conventional Gd³⁺ chelate (Fig. 87.1A). Figure 87.2 illustrates a liver metastasis prior to Fig. 87.1 (Fig. 87.2A), immediately after (Fig. 87.2B), and at 1 hour after (Fig. 87.2C

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