Right Upper Quadrant Pain

Chapter 1

Right Upper Quadrant Pain

Charlotte Henningsen and Gregory Logsdon

Right upper quadrant (RUQ) pain is a common clinical problem. The causes of RUQ pain include cholelithiasis and other gallbladder diseases; however, liver diseases and neoplasms (see Chapters 2 and 3) may manifest with similar symptoms. A thorough clinical examination, laboratory tests, and an RUQ ultrasound may be used to reveal the source of the discomfort. When gallbladder and liver diseases are suspected, the sonographer should take note of specific laboratory findings including bilirubin levels, liver function test results, and white blood cell counts.

In addition to the conditions discussed in this chapter, right-sided pain may be associated with diseases of the kidney (see Chapters 5, 6, and 7), the pancreas (see Chapter 4), and the gastrointestinal (GI) tract.


Normal Sonographic Anatomy

The gallbladder is a teardrop-shaped structure that is responsible for the concentration and storage of bile. The normal gallbladder is 7 to 10 cm in length and 2.5 to 4 cm in diameter. The lumen of the gallbladder is anechoic in normal circumstances, and the gallbladder wall appears thin and smooth, with a measurement of less than 3 mm in thickness (Fig. 1-2).1 A sonographic evaluation of the gallbladder should also include an evaluation of the bile ducts. The common bile duct (CBD) (Fig. 1-3) should measure 6 mm or less, and the common hepatic duct should measure 4 mm or less. The CBD size may be increased in patients who have undergone a cholecystectomy and in older patients.


Cholelithiasis, also known as gallstones, is the most common disease of the gallbladder. Gallstones are usually composed of cholesterol, although stones may be made up of pigment or have a mixed composition. A predisposition for gallstone formation is seen in patients with impaired gallbladder motility and bile stasis. The typical patient has the “five f’s”: fat, female, forty, fertile, and flatulent. Family history, sedentary lifestyle, absence of alcohol use, and inflammatory bowel disease may contribute to gallstone formation; patients with gallstones also show an increased prevalence of heart disease.2 Other risk factors that predispose a patient to the development of gallstones include diet-induced weight loss, pregnancy (Fig. 1-4), total parenteral nutrition (TPN), diabetes, estrogen use, oral contraceptive use, hemolytic diseases, and white or Hispanic race. Cholelithiasis has also been identified in both genders, in children, and in the fetus.

Most individuals with cholelithiasis are asymptomatic. A symptom of cholelithiasis is RUQ pain, especially after meals; patients may also have increased symptoms after a meal high in fat. Other symptoms include epigastric pain, nausea and vomiting, and pain that radiates to the shoulder.


Cholecystitis is an inflammation of the gallbladder that can have many forms—acute or chronic, calculous or acalculous. In addition, acute cholecystitis may present with severe complications including emphysematous cholecystitis, gangrenous cholecystitis, and gallbladder perforation.

Acute Cholecystitis

The most common cause of acute cholecystitis is cholelithiasis that creates a cystic duct obstruction. Because of the high prevalence of associated cholelithiasis, acute cholecystitis is more common in female patients; however, when cholecystitis develops in male patients, it is usually more severe.3 Clinical symptoms include RUQ pain, fever, and leukocytosis. Serious complications can occur in patients with acute cholecystitis, including empyema, gangrenous cholecystitis, emphysematous cholecystitis, and gallbladder rupture.

Acalculous cholecystitis (ACC) is an acute inflammation of the gallbladder in the absence of cholelithiasis (Fig. 1-7). The etiology is multifactorial. ACC occurs in patients with TPN, postoperative patients, and trauma and burn patients. ACC is more common in male patients.

Emphysematous Cholecystitis

Emphysematous cholecystitis is a complication of acute cholecystitis in which gas invades the gallbladder wall and lumen, and may also be present in the biliary ducts. Emphysematous cholecystitis occurs with ischemia of the gallbladder wall and subsequent bacterial invasion. It is more common in male patients, and is frequently associated with underlying diseases such as diabetes mellitus and peripheral atherosclerotic disease.4 Complications of emphysematous cholecystitis include the development of gangrene of the gallbladder and gallbladder rupture.

Gangrenous Cholecystitis

Another complication of acute cholecystitis is gangrenous cholecystitis (Fig. 1-11), which is associated with increased morbidity and mortality and may lead to gallbladder perforation. The gallbladder wall is thickened and edematous, with focal areas of exudate, hemorrhage, and necrosis. Patients more commonly have generalized abdominal pain rather than a positive Murphy’s sign.

Gallbladder Perforation

Gallbladder perforation is a complication of acute cholecystitis that may develop within a few days to several weeks after the onset of the symptoms of the acute gallbladder inflammation. Perforation usually occurs in the gallbladder fundus after cystic duct obstruction, gallbladder distention, and resultant ischemia and necrosis.

Risk factors for gallbladder rupture include gallstones, infection, diabetes, trauma, malignant disease, drugs, angiitis, and atherosclerosis. Clinical presentation may include abdominal pain, leukocytosis, and fever. The mortality rate is significant.

Hyperplastic Cholecystosis

Hyperplastic cholecystosis refers to a group of proliferative and degenerative conditions that affect the gallbladder. The incidence of hyperplastic cholecystosis is increased in female patients. These benign conditions include adenomyomatosis and cholesterolosis and may be diffuse, segmental, or localized.


Adenomyomatosis of the gallbladder occurs with diffuse or localized hyperplasia of the gallbladder mucosa that extends into the muscular layer and results in mucosal diverticula, known as Rokitansky-Aschoff sinuses.6 Adenomyomatosis may be asymptomatic, or may be seen with symptoms similar to those of gallstones.


Cholesterolosis is characterized by the deposition of cholesterol across the gallbladder wall. It is also referred to as a strawberry gallbladder because of the appearance of the cholesterol deposits within the gallbladder mucosa. This condition may be localized or diffuse and is associated with cholelithiasis.

Sonographic Findings

Cholesterolosis may appear sonographically as multiple small cholesterol polyps that arise from the gallbladder wall (Fig. 1-14). These polypoid lesions do not shadow or move with variation in patient position. Comet-tail artifacts may also be identified emanating from the cholesterol polyps and may be indistinguishable sonographically from adenomyomatosis. Gallbladder polyps may also occur in isolation, and when they are small, they are insignificant.

Aug 27, 2016 | Posted by in ULTRASONOGRAPHY | Comments Off on Right Upper Quadrant Pain
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