Osseus Giant Cell Tumor
George Nomikos, Anthony G. Ryan, Peter L. Munk, and Mark Murphey
Clinical Presentation
A 25-year-old woman presented with a chief complaint of knee pain.
Figure 57A
Figure 57B
Figure 57C
Radiologic Findings
The lateral radiograph of the knee (Fig. 57A) shows a lytic lesion in the proximal tibia. The center of the lesion appears to be in the proximal metaphysis of the tibia; however, the lesion extends to the subchondral bone plate. The lesion demonstrates a narrow zone of transition, with adjacent patchy sclerosis in the surrounding bone. No mineralized matrix is identified in the lesion. The lesion is mildly heterogeneous on the sagittal T1-weighted image (Fig. 57B), with intensity slightly greater than that of skeletal muscle. On the sagittal T2-weighted image (Fig. 57C), the lesion remains predominantly intermediate in signal intensity. There is focal high signal intensity in the lesion that likely represents an area of cyst formation. Note the low signal intensity rim visible around portions of the lesion on both the T1- and T2-weighted images, representing a fibrous pseudocapsule.
Diagnosis
Giant cell tumor (GCT) of bone.
Differential Diagnosis
- Aneurysmal bone cyst
- Chondroblastoma
- Chondromyxoid fibroma
- Brown tumor
- Telangiectatic osteosarcoma
Discussion
Background
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