82 Primary Pulmonary Lymphoma


image Clinical Presentation

Asymptomatic 71-year-old man evaluated because of an abnormal chest radiograph

image Radiologic Findings

PA chest radiograph (Fig. 82.1) demonstrates multi-focal bilateral nodular opacities without associated lymphadenopathy or pleural effusion. Unenhanced chest CT (lung window) (Fig. 82.2) shows multi-focal subpleural nodular opacities of heterogeneous attenuation. Biopsy confirmed the diagnosis of primary pulmonary lymphoma of mucosa-associated lymphoid tissue (MALT). PA chest radiograph (Fig. 82.3) obtained three years later demonstrates interval growth and coalescence of multi-focal nodular opacities. Unenhanced chest CT (lung window) (Fig. 82.4) confirms interval growth of pulmonary lesions, which exhibit internal air bronchograms.

image Diagnosis

Primary Pulmonary Lymphoma; Marginal Zone B-Cell Lymphoma of MALT

image Differential Diagnosis

• Multicentric Lung Cancer

• Pulmonary Metastases

• Multi-focal Pneumonia

• Cryptogenic Organizing Pneumonia


Fig. 82.1


Fig. 82.2


Fig. 82.3


Fig. 82.4

image Discussion


Pulmonary lymphomas are subdivided into those lymphomas limited to the lung (primary) and those in which the lung is affected secondarily. A primary pulmonary lymphoma is defined as an extranodal pulmonary lymphoma without evidence of extrapulmonary involvement at diagnosis and during the subsequent three months. It is a rare lung malignancy and comprises approximately 0.5% of all primary lung neoplasms. Most (70–90%) primary pulmonary lymphomas are marginal zone lymphomas of MALT. Primary pulmonary diffuse large B-cell lymphomas account for approximately 5–20% of all primary pulmonary lymphomas. A secondary pulmonary lymphoma is much more frequent, occurs in approximately 50% of patients with lymphoma, and is more common in patients with Hodgkin lymphoma.


Primary pulmonary lymphomas

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Jan 14, 2016 | Posted by in RESPIRATORY IMAGING | Comments Off on 82 Primary Pulmonary Lymphoma
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