Epidemiology of Osteonecrosis of the Femoral Head in South Korea


Tools

Findings

Plain radiograph

(a) Ill-defined mottling/mixed sclerosis of the trabeculae

(b) Geographic and/or band-like sclerosis with or without (c, d, e)

(c) Crescent sign with (a) or (b)

(d) Microfracture with (a) or (b)

(e) Femoral head collapse with or without arthritis

MRI

(a) Geographic region of decreased marrow signal within normal fatty marrow

(b) Surrounding dense low-intensity line in all views

(c) White inner line (or double-line sign) in T2-weighted images

Scintigraphya

Abnormal (cold spots and adjacent hot areas) uptake of the radioisotope

Pathology

Microscopically confirmed pathology


aAny one of these findings is required to diagnose as ONFH, except for the single (+) findings in scintigraphy, which is considered as additive sign



The confirmed status of diagnosis was used as a binary variable, and a multiple logistic regression was used to calculate the probability of the diagnostic accuracy. Factors considered to affect the accuracy were gender, age, type of medical service (clinic, hospital, general hospital, university hospital), region (Seoul, metropolitan, others), and hospitalization. After correcting the diagnostic accuracy, the estimated nationwide prevalence of ONFH is presented as total counts and per 100,000 persons for each year from 2002 to 2006. The total number of beneficiaries of the National Medical Aid and National Health Insurance programs in Korea was used as the annual population.



7.2.3 Descriptive Epidemiology


The numbers of medical claims of ONFH from 2002 to 2006 were 15,683, 20,746, 22,304, 27,204, and 31,432, respectively. Among the 382 validation samples, 273 (71.5 %) were men and 109 (28.5 %) were women. In total, 209 (54.7 %) patients were hospitalized, while 173 (45.3 %) were treated as outpatients. The number of correct diagnoses among the medical claims was 274 (71.7 %). Significantly lower diagnostic accuracies were found for female patients and nonhospitalized patients (Table 7.2). Overall, 60.3 % of the total claims during 5 years were predicted to be true after regression analysis. The estimated prevalences of true ONFH from 2002 to 2006 constantly increased as 9,870, 12,394, 13,329, 16,230, and 18,691, respectively (Table 7.3). The prevalence per 100,000 population increased during this time period, from 20.53 to 37.96. The average annual prevalence was estimated at 14,103, corresponding to 28.91 per 100,000 population (Table 7.3). The ratio differed from that reported in other studies [1921]. A male predominance, with a ratio of 3.9:1, was found. Bilateral involvement was found to be relatively low (37.1 %) versus the generally accepted view (50–60 %).


Table 7.2
Factors affecting the diagnostic accuracy of ONFH



























































Variables
 
Odds ratioa (95 % confidence interval)

Gender

Male

1.00

Female

0.40a (0.23–0.68)

Age (years)

<39

1.00

40–59

1.36 (0.63–2.94)

60+

0.83 (0.40–1.75)

Type of medical service

Clinic

1.00

Hospital

1.04 (0.37–2.89)

General hospital

0.88 (0.38–2.04)

University hospital

0.77 (0.36–1.64)

Region

Seoul

1.00

Metropolitan

1.84 (0.91–3.71)

Others

0.78 (0.37–1.65)

Hospitalized

Outpatient

1.00

Inpatient

7.06a (3.99–12.52)


aStatistically significant in 95 % confidence interval



Table 7.3
Estimated nationwide prevalence of ONFH in Korea




































Year

Men

Women

Total

Number

Per 100,000 men

Number

Per 100,000 women

Number

Per 100,000 population

2002

8.28 (8.11–8.46)

34.35 (33.61–35.10)

1.59 (1.51–1.67)

6.62 (6.30–6.95)

9.87 (9.68–10.07)

20.53 (20.13–20.94)

2003

9.88 (9.69–10.08)

40.49 (39.70–41.30)

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Mar 18, 2017 | Posted by in GENERAL RADIOLOGY | Comments Off on Epidemiology of Osteonecrosis of the Femoral Head in South Korea

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