Cystic or linear collections of gas in subserosal or submucosal layers of GI tract wall
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Pneumatosis intestinalis: Most common form of intramural gas, found in SB more often than colon
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Pneumatosis coli: Rounded collections of gas in distal colonic wall, usually asymptomatic finding
IMAGING
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Best imaging tool: MDCT with lung windows to detect intramural, intraperitoneal, and venous gas
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Pneumatosis of ischemic etiology
Dilated bowel lumen (ileus), thickened wall, abnormal wall enhancement
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Ascites, may be of blood density (> 35 HU)
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± pneumoperitoneum or pneumoretroperitoneum
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± mesenteric or portal venous gas
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Portal venous gas is not always due to bowel infarction
TOP DIFFERENTIAL DIAGNOSES
CLINICAL ISSUES
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Most common signs/symptoms
Nonischemic causes: Patients are often asymptomatic
Bowel ischemia: Nausea, abdominal pain, distension, melena, fever, vomiting, cough (depending on etiology)
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Treatment and prognosis depend on etiology
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Direct communication with clinical team is essential
DIAGNOSTIC CHECKLIST
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Important to recognize pneumatosis intestinalis, but significance depends on etiology and clinical setting
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Nonischemic causes of pneumatosis are usually asymptomatic, of little clinical significance
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Recognition of pneumatosis demands direct communication with clinical team to determine its likely etiology and optimal management
TERMINOLOGY
Synonyms
Definitions
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Cystic or linear collections of gas in subserosal or submucosal layers of gastrointestinal (GI) tract wall
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Pneumatosis intestinalis: Most common form of intramural gas, found in small bowel more often than colon
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Pneumatosis coli: Rounded collections of gas in distal colonic wall, usually asymptomatic finding
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Pneumatosis is a descriptive sign, not a disease or diagnosis
IMAGING
General Features
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Best diagnostic clue
Cystic or linear distribution of gas along bowel wall on CT
Fluoroscopic Findings
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Barium studies
Pneumatosis intestinalis
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Mottled, bubbly, or linear collections of gas in bowel wall; feces-like appearance
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Dilated bowel loops ± thumbprinting
Pneumatosis coli
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Radiolucent cysts resembling polyps, clustered along colonic contours
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Multiple large gas-filled cysts with scalloped defects in bowel wall, mimicking inflammatory pseudopolyps
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Concentric compression of colonic lumen by cysts
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Striking lucency of gas-filled cysts
CT Findings
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CECT
Pneumatosis intestinalis
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Band-like: Bands or linear distribution of gas in affected bowel wall
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Linear or curvilinear shape
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Ischemic etiology: Dilated bowel lumen (ileus), thickened wall, abnormal enhancement
Ascites, may be of blood density (> 35 HU)
± mesenteric arterial or venous thrombosis
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± pneumoperitoneum or pneumoretroperitoneum
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± mesenteric or portal venous gas
Portal venous gas collects in liver periphery
Biliary gas collects in central ducts near porta hepatis
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Nonischemic causes: Ileus and ascites are usually absent
Pneumatosis coli
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Bubble-like: Isolated collections of air or clusters of cysts in left colonic wall
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Usually not accompanied by ileus, ascites, or clinical signs of acute abdominal process
Imaging Recommendations
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Best imaging tool
Multiplanar CT with lung windows to detect gas
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Protocol advice
CT with IV contrast at 3-4 mL/sec, 1.5-3 mm collimation
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35-second image delay, repeat venous phase after 80 seconds
Water for oral contrast facilitates CT angiography
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Multiplanar reformation is essential
DIFFERENTIAL DIAGNOSIS
Bowel Necrosis
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Ischemic enteritis, volvulus, necrotizing enterocolitis
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Mucosal damage → entry of bacteria (mainly enteric organisms) into bowel wall → gas in wall