The Epidemiology of Osteonecrosis in Japan


Age at identified

Year

All years

1999

2000

2001

2002

2003

2004

2005

2006

2007

2008

Incidence rate/100,000 person-years

−20

0.18

0.18

0.00

0.19

0.49

0.20

0.20

0.00

0.11

0.32

0.19

20–29

1.43

0.78

1.08

1.22

2.48

1.12

1.82

1.36

1.23

1.41

1.39

30–39

1.97

2.62

2.37

1.85

3.45

3.96

4.10

3.54

3.25

2.41

2.95

40–49

2.42

2.98

4.44

3.62

6.76

2.94

4.24

4.86

4.83

3.31

4.04

50–59

2.25

2.96

2.15

2.94

6.20

4.23

4.90

5.04

4.55

4.17

3.94

60–69

2.52

2.34

2.59

2.56

4.92

3.51

4.34

4.25

3.44

3.43

3.39

70–79

1.04

1.30

2.18

1.63

4.55

3.34

4.89

4.91

3.98

2.50

3.03

80–

0.54

2.15

1.45

0.00

0.44

1.65

2.89

2.58

2.80

2.67

1.72

Crude rate

1.54

1.91

2.03

1.75

3.66

2.62

3.42

3.32

3.02

2.53

2.58

Age-adjusted rate

1.56

1.80

1.92

1.81

3.71

2.57

3.26

3.18

2.89

2.43

2.51


Reproduced from Ref. [7]





6.3 Other Data on the Incidence of Osteonecrosis


The Research Committee on Idiopathic Avascular Necrosis of the Femoral Head was established in 1975. The committee has reported five nationwide surveys on the prevalence of ON in Japan, which showed an annual increase. The prevalence was 6,700–8,200 (95 % confidence interval) in 1994 [8] and 10,100–12,800 (95 % confidence interval) in 2004 [9].

Previously, the incidence of nontraumatic or steroid-associated ON has been reported in disease-limited populations, such as systemic lupus erythematosus (SLE), organ transplantation, and sickle cell disease. Those reported data are summarized in Table 6.2. For example, in SLE patients, an MRI study showed the incidence of ONFH to be 31.1 % (14 of 45 patients) in 1 year [10], while in renal allograft recipients, osteonecrotic changes on MRI have been detected in 25.5 % of the patients (13 of 51 patients) [11].


Table 6.2
Reported incidence of nontraumatic ON of the femoral head







































Population

Reference

Year of publishing

Diagnostic method

No. of people

Incidence (per 100 person-years)

SLE (high dose)

Nakamura et al. [12]

2010

MRI

169

34.6

Nagasawa et al. [10]

2005

MRI

45

31.1

Oinuma et al. [13]

2001

MRI

72

44.4

(Low dose)

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Mar 18, 2017 | Posted by in GENERAL RADIOLOGY | Comments Off on The Epidemiology of Osteonecrosis in Japan

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