Spectroscopic Imaging of the Mouse Brain
of water and lipid tissue in humans and animal models. A wealth of information can be added to these parameters using MR spectroscopy (MRS) since levels of metabolites can in…
of water and lipid tissue in humans and animal models. A wealth of information can be added to these parameters using MR spectroscopy (MRS) since levels of metabolites can in…
Fig. 1. In vivo 3D acquisition of a mouse brain: sagittal (top), coronal (left), and axial (right) views. Cerebral ventricles filled with CSF appear hyperintense on these images (arrows). The…
Fig. 1. A digital image with a matrix of 6 × 4 (0.06 × 0.06 mm in-plane resolution) and five 0.1 mm thick slices with a 0.05 mm slice gap. Image registration: Image…
Fig. 1. Stress hormones and the onset of the stress reaction. 2 Materials 2.1. Anaesthesia: the animal is usually kept under anaesthesia for the entire MRI experiment to prevent animal…
Fig. 1. Subject preparation. (a) Preparation of the home-made mask (1), the jacket (2), the cloacal temperature probe (3) and the pneumatic sensor (4) to measure the respiration rate of…
Fig. 1. MR images of mouse brain with Mel57-VEGF-A165 tumors, acquired prior to (a and c) and following administration of Gd-DTPA (b) and USPIO (d). Immunostainings for pericytes (e) and…
Fig. 1. This flow chart summarizes the various steps a contrast agent is taken through to ensure that it does not deleteriously affect cellular functions, while at the same time…
Fig. 1. Immediately after the onset of a focal loss of perfusion, a cascade of detrimental events is initiated. Excitotoxicity lethally damages neurons and glia, and triggers a number of…
where SI n is the signal intensity at each time point, SI0 is the initial signal intensity, and TE is the echo time. One needs to keep the units consistent….
Fig. 1. Example of an MRI-compatible animal imaging chamber, with features for accurate body centralization and limb positioning. The sealed chamber ensures stable anesthetic delivery. Slots can be included for…