Combining Radiotherapy and Immunotherapy: Emerging Preclinical Observations of Lymphocyte Costimulatory and Inhibitory Receptor Modulation

Jun 2, 2017 by in GENERAL RADIOLOGY Comments Off on Combining Radiotherapy and Immunotherapy: Emerging Preclinical Observations of Lymphocyte Costimulatory and Inhibitory Receptor Modulation

  Cell surface receptor Cell surface receptor ligand Therapeutic agonist/antagonist examples Costimulatory CD40 CD40L CP-870,893 (Pfizer), dacetuzumab (Seattle Genetics)  CD134/OX40 CD252/OX40L MEDI0562, MEDI6469, MEDI6383 (AstraZeneca)  GITR GITRL TRX518 (GITR Incorporated) …

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Receptor Tyrosine Kinases as Targets for Enhancing Tumor Radiosensitivity

Jun 2, 2017 by in GENERAL RADIOLOGY Comments Off on Receptor Tyrosine Kinases as Targets for Enhancing Tumor Radiosensitivity

© Springer International Publishing Switzerland 2017Philip J. Tofilon and Kevin Camphausen (eds.)Increasing the Therapeutic Ratio of RadiotherapyCancer Drug Discovery and Development10.1007/978-3-319-40854-5_2 2. Receptor Tyrosine Kinases as Targets for Enhancing Tumor Radiosensitivity Thomas J. Hayman1   and Joseph N. Contessa1   (1)…

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Remodeling the Irradiated Tumor Microenvironment: The Fifth R of Radiobiology?

Jun 2, 2017 by in GENERAL RADIOLOGY Comments Off on Remodeling the Irradiated Tumor Microenvironment: The Fifth R of Radiobiology?

© Springer International Publishing Switzerland 2017Philip J. Tofilon and Kevin Camphausen (eds.)Increasing the Therapeutic Ratio of RadiotherapyCancer Drug Discovery and Development10.1007/978-3-319-40854-5_6 6. Remodeling the Irradiated Tumor Microenvironment: The Fifth R of Radiobiology? Mary Helen Barcellos-Hoff1   (1) Department…

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Foundations of a Brachytherapy Practice

Jun 2, 2017 by in GENERAL RADIOLOGY Comments Off on Foundations of a Brachytherapy Practice

15   Foundations of a Brachytherapy Practice David Jeffrey Demanes, Ron DiGiaimo, Casilda Menchaca-Garcia, and Tamara Syverson The purpose of this chapter is to describe the prerequisites and methods for…

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Genitourinary Brachytherapy

Jun 2, 2017 by in GENERAL RADIOLOGY Comments Off on Genitourinary Brachytherapy

4   Genitourinary Brachytherapy André-Guy Martin, Frédéric Lacroix, Thomas Niedermayr, Paul L. Nguyen, and Peter F. Orio, III The predominant form of genitourinary brachytherapy performed worldwide is prostate brachytherapy, either…

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Vascular Brachytherapy

Jun 2, 2017 by in GENERAL RADIOLOGY Comments Off on Vascular Brachytherapy

14   Vascular Brachytherapy Chien Peter Chen, Ray Lin, and Prabhakar Tripuraneni Vascular disease is the number one cause of mortality and morbidity in the United States. Cardiovascular disease accounts…

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