Management of Melanoma
T-stage Breslow thickness Excision margin Level and grade of evidence pTis In situ melanoma 5 mm III, B pT1 <1.0 mm 1 cm Ib, A pT2 1.0–2.0 mm 1–2 cm…
Pathology of Melanoma
Essential features Ulceration Present/absent Breslow thickness In millimetres Margin status Both in situ and invasive components Mitotic count Per mm2 Lymph node status • Number of sentinel nodes received • Number of…
Hierarchical Cluster Analysis to Aid Diagnostic Image Data Visualization of MS and Other Medical Imaging Modalities
Fig. 1 Tumor tissue embedded in a gelatin block and four markers placed in four corners MRI images were acquired using the 0.25 T Esaote GScan. The sample was centrally…
Laser Ablation Inductively Coupled Plasma Mass Spectrometry Imaging of Plant Metabolites
Fig. 1 Schematic diagram on (a) cryosection of barley seed, (b) mounted the section, and the (c) LA-ICP-MS image 3.3 Leaf Material for Imaging 1. Clean and remove any…
Imaging MS of Rodent Ocular Tissues and the Optic Nerve
Fig. 1 Image displaying (a) alignment of mouse optic nerve tissue along hypodermic needle after dissection, (b) displaying initial freezing process where the lower portion of the hypodermic needle is…
DESI Mass Spectrometry Imaging (MSI)
Fig. 1 Parts of the Waters DESI sprayer 2.4 Software 1. Prosolia Omni Spray 2D: software to control the DESI source for DESI sprayer optimization (Prosolia Inc., Indianapolis, IN,…
Mass Spectrometry Imaging of Drugs of Abuse in Hair
Fig. 1 Cutting apparatus used for longitudinal sectioning of hair samples. (a) Image of the in-house built cutting apparatus and (b) schematic of the cutting apparatus 2. Following decontamination,…
Rodent Whole-Body Sectioning and MALDI Mass Spectrometry Imaging
Fig. 1. (a) Stereotaxic frame used to freeze the carcass while maintaining spinal alignment. (N.B. the array of holes in each side permits the free flow of the hexane/dry ice…
ToF-SIMS Parallel Imaging MS/MS of Lipid Species in Thin Tissue Sections
and Ron M. A. Heeren1 (1) Maastricht MultiModal Molecular Imaging (M4I) Institute, Maastricht University, Universiteitssingel 50, 6229, ER, Maastricht, The Netherlands (2) Physical Electronics, Inc., Chanhassen, Minnesota 55317, USA Anne Lisa Bruinen Email: a.bruinen@maastrichtuniversity.nl…
