Fig. 5.1 PET images differentiate neoplastic areas with hypermetabolic activity from within the surrounding normal tissue. (a) CT image , (b) PET image, and (c) fused PET/CT image . The…
Fig. 9.1 Schematic representation of present radiotherapy workflow pathway To date the most impactful strategy to improve the therapeutic ratio in radiotherapy has involved improvements in the accuracy and precision…
Fig. 10.1 A schematic depiction of the interaction of nanoparticles with ionizing radiation [24]. With permission from J.W. Bergs et al. Safety and Potential Toxicity of Nanoparticles For the successful…
Fig. 1.1 Responses of mammalian cells to DNA DSBs induced by gamma irradiation following induction of DNA DSBs by ionising radiation, a DNA damage response consisting of cell cycle checkpoint…
Fig. 4.1 Sequence of events following radiation exposure . The chart is divided into three parts by dashed lines suggesting events and reactions that might be modified by radiation protectors…
Cell surface receptor Cell surface receptor ligand Therapeutic agonist/antagonist examples Costimulatory CD40 CD40L CP-870,893 (Pfizer), dacetuzumab (Seattle Genetics) CD134/OX40 CD252/OX40L MEDI0562, MEDI6469, MEDI6383 (AstraZeneca) GITR GITRL TRX518 (GITR Incorporated) …
Fig. 3.1 Histone deacetylases are responsible for counteracting the reaction of HATs by removing the acetyl groups from acetyl-lysine residue. However, they also target non-histone proteins that control cellular processes…
© Springer International Publishing Switzerland 2017Philip J. Tofilon and Kevin Camphausen (eds.)Increasing the Therapeutic Ratio of RadiotherapyCancer Drug Discovery and Development10.1007/978-3-319-40854-5_2 2. Receptor Tyrosine Kinases as Targets for Enhancing Tumor Radiosensitivity Thomas J. Hayman1 and Joseph N. Contessa1 (1)…
© Springer International Publishing Switzerland 2017Philip J. Tofilon and Kevin Camphausen (eds.)Increasing the Therapeutic Ratio of RadiotherapyCancer Drug Discovery and Development10.1007/978-3-319-40854-5_6 6. Remodeling the Irradiated Tumor Microenvironment: The Fifth R of Radiobiology? Mary Helen Barcellos-Hoff1 (1) Department…
15 Foundations of a Brachytherapy Practice David Jeffrey Demanes, Ron DiGiaimo, Casilda Menchaca-Garcia, and Tamara Syverson The purpose of this chapter is to describe the prerequisites and methods for…
