© Springer Science+Business Media New York 2016Luca Saba and Eytan Raz (eds.)Neurovascular Imaging10.1007/978-1-4614-9029-6_49 3. Nonatherosclerotic Vascular Disease: Biological and Pathological Basis Pierleone Lucatelli1 , Beatrice Sacconi1 and Carlo Catalano1 (1) Department of Radiological, Oncological and Anatomo-Pathological Sciences, Sapienza University…
Molecule Function Nitric oxide (NO) Vasodilator Prostacyclin (PGI2) Vasodilator Endothelin-1 (ET-1) Vasoconstrictor Endothelium-derived contracting factors (EDCF) Vasoconstrictor The activity of the VSMC can be regulated directly by the sympathetic and…
Fig. 17.1 Representative autoradiograms of rat (upper row) and neonate pig brains (lower row) obtained with an α7 nAChR ligand ([125I]α-bungarotoxin) and the semi-selective α4β2 ligand [3H]epibatidine. For anatomic reference,…
Fig. 13.1 Regions of significantly changed rCBF during spatial discrimination tasks in (a) a placebo group compared with results from a fixation task and (b, c) a d-chlorpheniramine-treated group compared…
Fig. 18.1 Structure of NMDARs and location of ligand-binding site Positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging for NMDARs could be powerful tools for obtaining…
Fig. 24.1 Summary diagram of primate serotonergic system. Main nuclei are indicated by initial letters and fibre pathways are shaded. Am amygdaloid nucleus, C cerebellum, Hip hippocampus, Hyp hypothalamus, Sep…
Fig. 16.1 Chemical structures of 4-MPB (left), (+)3-MPB and its N-alkyl substitution analogues, (+)3-EPB and (+)3-PPB (right). Affinity (Ki) values of each compound were determined by in vitro assay with…
Fig. 15.1 Ionotropic and metabotropic glutamate receptors (Source: http://www.ucl.ac.uk/ioo/research/salt/glutamat.htm (Prof. Tom Salt)) The iGluRs are the principal mediators of excitatory neurotransmission. These are ligand-gated cationic-selective channels which are permeable to…
Fig. 26.1 Chemical structures of clinically used sigma ligands for brain imaging The first radioligand used for imaging sigma1 receptors in the CNS was [11C]SA4503 (Fig. 26.1), which was developed…
Fig. 14.1 Neurosteroidogenesis: Steroidogenesis follows a sequential, highly compartmentalized reaction, with the translocation of cholesterol from cytoplasm to mitochondria in the cells of CNS, which is mediated by steroidogenic acute…
