PET Imaging of ABC Transporters in the BBB
CNS disease ABC transporters examined in the context of this disease References Ischemic stroke ABCB1, ABCC1 ElAli and Hermann (2010), Kilic et al. (2008), Spudich et al. (2006) Epilepsy ABCB1,…
NEUROLOGICAL IMAGING
Imaging Type 1 Glycine Transporters in the CNS Using Positron Emission Tomography
Tracer [11C]GSK931145 [18F]MK-6577 [11C]CMPyPB [11C]RO501852 [11C]RO5013853 [11C]-N-Methyl_SSR504734 ([11C]GSK565710) Structure MW 350.51 487.09 499.11 443.19 497.16 410.87 LogD (pH7.4) 2.5 2.9 3.2 2.2 2.3 2.97 pIC50(GlyT1) 8.4 8.7 (human) 8.4…
Principles of Brain Perfusion SPECT
Clinical indication Typical brain perfusion SPECT findings Differential diagnosis in dementia (Borghesani et al. 2010) Alzheimer’s disease (AD) Hypoperfusion of bilateral temporoparietal association cortices (often asymmetric) with characteristic sparing of…
Monoamine Oxidase A and Serotonin Transporter Imaging with Positron Emission Tomography
[11C]Clorgyline [11C]Harmine [11C]Befloxatone Selectivity Excellent (Fowler et al. 1987) Excellent (Bergstrom et al. 1997b) Excellent (Dolle et al. 2003) Reversibility Not reversible (Fowler et al. 1987) Highly reversible (Ginovart…
Cerebral Blood Flow Measurement with Oxygen-15 Water Positron Emission Tomography
Frame duration[s] 5 10 30 Number of frames 24 12 2 The advantageous short half-life of the tracer (122 s) enables the performance of multiple image acquisition scans in rapid…
Cerebral Glucose Metabolism
where C(18F) is the total fluorine activity measured in the tissue, which is determined directly in the PET; C(FDG) is the concentration of free FDG in the tissue, calculated from…
Progress in PET Imaging of the Norepinephrine Transporter System
Fig. 19.1 Effect of cocaine dependence on [11C]MRB binding in humans. BP ND (binding potential) values were compared between healthy control and cocaine-dependent individuals 19.3.1.2 Duration of Abstinence Effect on…
PET Tracers for Beta-Amyloid and Other Proteinopathies
Fig. 8.1 Beta amyloid (Aß) processes from soluble amyloid precursor protein (s-APP) to different forms of Aß with their possible interaction with the nerve terminal (synapse) 8.2 Molecular Imaging The…
PET and SPECT Imaging of the Central Dopamine System in Humans
Fig. 10.1 Simplified diagram of a striatal dopaminergic synapse. On the presynaptic side, potential markers for imaging of the integrity of dopaminergic neurons in humans are shown. [18F]FDOPA and [18F]FMT…
Radioligands for Imaging Vesicular Monoamine Transporters
Mouse fmol/mg protein a [ 11 C]TBZ % inj dose/g b Striatum 1,345 4.96 Thalamus 111 2.06 Hippocampus 141 2.01 Hypothalamus 411 2.96 Pons-medulla 167 1.96 Cortex (frontal) 115 1.91…
