Fig. 33.1 [123I]FP-CIT SPECT scan obtained (3 h after injection) in a 21-year-old healthy female control (left side) and in a 78-year-old healthy female control (right side). Striatal binding of…

Fig. 28.1 Decreasing striatal 123I-β-CIT binding over time in patients with APS. Striatal 123I-β-CIT binding in individual patients with atypical parkinsonian syndromes, including MSA (circles), PSP (squares), and CBD (triangles),…

Fig. 45.1 Typical examples of 11C-NMSP microPET imaging in various conditions. Coronal and axial sections of rat brain are shown. White cross markers in the coronal and axial sections indicate…

Fig. 16.1 FDG-PET scan showing serial axial images and surface-rendered z-score maps of significant hypometabolism relative to a normal control database showing selective mesial occipital hypometabolism in a patient with…

In contrast to MRI, which gives a pictorial representation of body cross sections, MRS yields a “spectrum” of peaks at different radiofrequencies (“chemical shifts”). The chemical shift that results from…

Scan type Radiotracer Participants Main findings Reference SPECT 123I-IMP 1 ALS-FTD 1 HC Marked loss of frontotemporal uptake Sawada et al. (1988) 17 ALS (1 FU after 9 months); 15…

Fig. 48.1 Ligand-gated ion channels are probably the most relevant targets for general anaesthetics. A dark green or pink spot indicates significant potentiation or inhibition, respectively, of agonist actions at…

Authors N Diagnosis Time since insult (month(s)) Main findings Levy et al. (1987) 7 UWS 1–72 60 (53–67 %) decrease in metabolism DeVolder et al. (1990) 7 UWS 1–4 53…

Fig. 19.1 Example of mediastinal and cardiac region of interest (ROI) on anterior planar image. The left ventricular ROI was drawn including the ventricular cavity (H), and a rectangular ROI…

Fig. 11.1 In the SPM analysis the coloured clusters label the significantly lower α4β2*-nAChR availability by assessment of the 2-FA distribution volume ratio (2-FA-DVR) in AD and MCI patients (pilot…