Stereotactic Body Radiation Therapy (SBRT) or Alternative Fractionation Schedules
where n = number of treatment fractions, d = dose per fraction, and α/β is the ratio of the linear and quadratic components of the cell survival curve ; for…
Novel Imaging for Treatment Planning or Tumor Response
Fig. 9.1 Schematic representation of present radiotherapy workflow pathway To date the most impactful strategy to improve the therapeutic ratio in radiotherapy has involved improvements in the accuracy and precision…
Application of Functional Molecular Imaging in Radiation Oncology
Fig. 5.1 PET images differentiate neoplastic areas with hypermetabolic activity from within the surrounding normal tissue. (a) CT image , (b) PET image, and (c) fused PET/CT image . The…
Increasing the Therapeutic Efficacy of Radiotherapy Using Nanoparticles
Fig. 10.1 A schematic depiction of the interaction of nanoparticles with ionizing radiation [24]. With permission from J.W. Bergs et al. Safety and Potential Toxicity of Nanoparticles For the successful…
Improving the Therapeutic Ratio of Radiotherapy by Targeting the DNA Damage Response
Fig. 1.1 Responses of mammalian cells to DNA DSBs induced by gamma irradiation following induction of DNA DSBs by ionising radiation, a DNA damage response consisting of cell cycle checkpoint…
Radioprotection as a Method to Enhance the Therapeutic Ratio of Radiotherapy
Fig. 4.1 Sequence of events following radiation exposure . The chart is divided into three parts by dashed lines suggesting events and reactions that might be modified by radiation protectors…
Combining Radiotherapy and Immunotherapy: Emerging Preclinical Observations of Lymphocyte Costimulatory and Inhibitory Receptor Modulation
Cell surface receptor Cell surface receptor ligand Therapeutic agonist/antagonist examples Costimulatory CD40 CD40L CP-870,893 (Pfizer), dacetuzumab (Seattle Genetics) CD134/OX40 CD252/OX40L MEDI0562, MEDI6469, MEDI6383 (AstraZeneca) GITR GITRL TRX518 (GITR Incorporated) …
Histone Deacetylase Inhibitors and Tumor Radiosensitization
Fig. 3.1 Histone deacetylases are responsible for counteracting the reaction of HATs by removing the acetyl groups from acetyl-lysine residue. However, they also target non-histone proteins that control cellular processes…
Remodeling the Irradiated Tumor Microenvironment: The Fifth R of Radiobiology?
© Springer International Publishing Switzerland 2017Philip J. Tofilon and Kevin Camphausen (eds.)Increasing the Therapeutic Ratio of RadiotherapyCancer Drug Discovery and Development10.1007/978-3-319-40854-5_6 6. Remodeling the Irradiated Tumor Microenvironment: The Fifth R of Radiobiology? Mary Helen Barcellos-Hoff1 (1) Department…
Receptor Tyrosine Kinases as Targets for Enhancing Tumor Radiosensitivity
© Springer International Publishing Switzerland 2017Philip J. Tofilon and Kevin Camphausen (eds.)Increasing the Therapeutic Ratio of RadiotherapyCancer Drug Discovery and Development10.1007/978-3-319-40854-5_2 2. Receptor Tyrosine Kinases as Targets for Enhancing Tumor Radiosensitivity Thomas J. Hayman1 and Joseph N. Contessa1 (1)…
