Bombesin Analogs for Receptor-Mediated Imaging
SN Receptor subtype Native peptide Origin 1 NMB-R or BB1 Neuromedin B Mammalian 2 GRP-R or BB2 Gastrin-releasing peptide Mammalian 3 BRS-3 or BB3 Bombesin Mammalian 4 BRS-4 or BB4 Bombesin…
Generators: Past, Present, and Future
Fig. 1 Progress in 68Ge/68Ga radionuclide generators I: design of cows towards medicine The concept of the solid-phase-based generator is illustrated in Fig. 2; the original sketch is taken from the original publication…
as Neoadjuvant Treatment in NET
Fig. 1 99mTc-EDDA/HYNIC-TOC SRS and CT before and after neoadjuvant therapy with PRRT in a patient with inoperable midgut tumor (male, 48 years old) Fig. 2 99mTc-EDDA/HYNIC-TOC SRS and CT before and after…
68Ga-Labeled Peptides for Molecular Imaging and Therapy: Synthesis and Preliminary In Vitro and In Vivo Evaluation in a Melanoma Model System
Fig. 1 Cyclized α-MSH analogs: a MTII, a seven-amino-acid derivative of α-MSH cyclized through lactamization of Asp2 and Lys7, and b ClickMTII, where the aspartic acid has been replaced by propargylglycine…
Uptake of 68Ga-DOTATOC in Spleen as Compared to Splenosis: Measurement by PET/CT
Organ/region of interest SUVmax (mean ± SD) Spleen 28.8 ± 12.5 Renal cortex 12.8 ± 3.4 Liver 11.6 ± 3.8 Blood pool 2.3 ± 1.1 3.2 Postpancreatectomy SSTR PET/CT Pre PRRNT The mean SUVmax of the splenosis (10.5 ± 4.3) measured in…
Experience in Peptide Receptor Radionuclide Therapy
in 3–5 cycles, 4–8 interval Fixed doses 3–4 × 2.96 GBq each 6–8 weeks 4 × 3.7 GBq each 6–8 weeks 4 × 2.96 GBq 90Y–DOTATATE every 12 weeks + 3.7 GBq 177Lu–DOTATATE after 6 weeks For 177Lu–DOTATATE, 3–5× 7.4 GBq each 8–12 weeks The…
Uptake of 68Ga-DOTATOC and 68Ga-DOTATATE in PET/CT of Gastroenteropancreatic Neuroendocrine Tumors
Pat. no. Age (years) Sex Primary NET site Previous treatments Ki-67 SUVmax 68Ga-DOTATATE SUVmax 68Ga-DOTATOC 1 49 Male Foregut (gastric) Surgery, SIRT, PRRT 30 11.1 13.8 2 77 Female Midgut…
and Phage Display Selected Peptides for Imaging and Therapy of Cancer
Fig. 1 Schematic illustrating traditional approach compared with receptor targeting A disadvantage of the conventional bifunctional chelating system is that only one radioactive molecule per targeting moiety at most is delivered….
Experience with 68Ga-DOTATATE Preparation
Site Number of cases (histology–neuroendocrine cancer) 1998–2002 2003–2007 1998–2007 Percentage of tumor of the site Nasopharynx (ICD-9 147) 3 3 6 0.2 Esophagus (ICD-9 150) 3 3 6 0.7 Stomach…
of Different Positron Emission Tomography Tracers in Patients with Recurrent Medullary Thyroid Carcinoma: Our Experience and a Review of the Literature
Ambrosini V, Marzola MC, Rubello D et al (2010) (68)Ga-somatostatin analogues PET and (18)F-DOPA PET in medullary thyroid carcinoma. Eur J Nucl Med Mol Imaging 37:46–48PubMedCrossRef Beheshti M, Pöcher S, Vali…
